169,776 research outputs found
Nuclear myosin VI enhances RNA polymerase II-dependent transcription
No full textAbstract not availableSarah Vreugde, Carmelo Ferrai, Annarita Miluzio, Ehud Hauben, Pier Carlo Marchisio, Massimo P. Crippa, Mario Bussi, Stefano Biff
GLI STUDI SULLE SOCIETA' DI MUTUO SOCCORSO IN SARDEGNA: LO STATO DELL'ARTE
No full textThe theme of this work is the analysis of the findings of the studies of the Mutual aid Society of Sardinia.
We have taken into consideration the bibliography produced and the initiatives aiming to safeguard the heritage formed by the archive and the mutual society culture
ATTI DEL CONVEGNO INTERNAZIONALE DELLE SOCIETà DI MUTUO SOCCORSO DELLA SARDEGNA
No full textThis conference held in Aggius (SS), represented an occasion for meeting and exchange of experiences for scholars and mutual aid operators especially for the participation of Corsica and Belgium thanks to the presence of AIM (Association Internationale de la Mutualite’).
It has also been an important occasion to attract young people as their absence has been a major risk factor for the survival of the Mutual Aid Society.
The students of The Comprehensive Institute of Aggius have for the first time had the opportunity, to research and present a study on their local Mutual Aid Society also using the documentation found in the social archive.
This has been possible thanks to the support of their teachers and the coordination of the Sardinian Mutual aid Societies whose curator of the acts is responsible for the scientific side
Winter to spring variations of chromophoric dissolved organic matter in a temperate estuary (Po river, Northern Adriatic Sea)
No full textCombined anterior cruciate ligament reconstruction and unicompartimental knee arthroplasty
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
TERAPIA CON FARMACI ANTI TNF ALFA: EVENTI AVVERSI
No full textIl trattamento precoce con farmaci antiTNF migliora segni e sintomi dell'AR e previene il danno strutturale.
Abbiamo esaminato gli eventi avversi in 54 pazienti affetti da AR attiva trattati con farmaci biologici anti TNF alfa. 7/54 pazienti hanno interrotto il trattamento per la comparsa di eventi avversi di grado severo. 17/54 hanno mostrato eventi avversi lievi senza interruzione di trattamento.
I pazienti con una maggior durata di malattia e con più elevati indici di disabilità sono candidati a mostrare con maggior frequenza eventi avversi di una certa entità
Prep1 directly regulates the intrinsic apoptotic pathway by controlling Bcl-XL levels
No full textThe Prep1 homeodomain transcription factor is essential in embryonic development. Prep1 hypomorphic mutant mouse (Prep1i/i) embryos (embryonic day 9.5) display an increased terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling reaction compared to wild-type (WT) littermates. Prep1i/i mouse embryo fibroblasts (MEFs) show an increased basal level of annexin V binding activity, reduction of the mitochondrial-membrane potential, and increased caspase 9 and 3 activation, indicating increased apoptosis. Prep1i/i MEFs also respond faster than WT MEFs to genotoxic stress, indicating increased activation of the intrinsic apoptotic pathways. We did not observe an increase in p53 or an abnormal p53 response to apoptotic stimuli. However, hypomorphic MEFs have decreased endogenous levels of antiapoptotic Bcl-XL mRNA and protein, and Bcl-x overexpression rescues the defect of Prep1i/i MEFs. Using transient transfections and chromatin immunoprecipitation, we identified the Bcl-x promoter as a novel target of Prep1. Thus, Prep1 directly controls mitochondrial homeostasis (and the apoptotic potential) by modulating Bcl-x gene expression
A transcription-dependent micrococcal nuclease-resistant fragment of the urokinase-type plasminogen activator promoter interacts with the enhancer
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