1,355,012 research outputs found
Principles of MicroRNA Involvement in Breast Cancer
No full textEditorial on the role of microRNAs in breast cancer
The support structure of the Long Racetrack magnet
No full textThe support structure of the Long Racetrack magnet, a prototype to prepare the next generation of 'inner triplet' quadrupole magnets for the LHC. (Image Courtesy Paolo Ferracin, LBNL
Il Decameron di Domenico Caronelli nella tradizione d'area veneta
No full textNel volume sono raccolti i contributi di trentadue studiosi, provenienti da varie Istituzioni e Università europee, presentati al Congresso Internazionale svoltosi a Udine dal 23 al 25 maggio 2013, in occasione dei settecento anni della nascita di Giovanni Boccacci
"Stupore era a udir dire". Itinerari didattici, letture e musica per l'opera di Giovanni Boccaccio
No full textIl volume raccoglie i contributi letterari, storici-artistici e musicali, prodotti dagli allievi di alcuni Istituti Scolastici di istruzione superiore delle province di Udine e Pordenone in occasione del Convegno tenuto a margine del Congresso Internazionale "Giovanni Boccaccio: tradizione, interpretazione e fortuna. In ricordo di Vittore Branca", svoltosi a Udine dal 23 al 25 maggio 2013, per celebrare i settecento anni dalla nascita dell'autore
Lo studio, i libri e le dolcezze domestiche. In memoria di Clemente Mazzotta, a cura di C.Griggio e R.Rabboni, Verona, Fiorini, 2010, pp.XXX-873.
No full textvolume contenente più di una trentina di contributi relativi a periodi ed autori diversi della Storia della Letteratura Italiana, quale omaggio alla figura di Clemente Mazzott
Vincenzio Borghini, Scritti su Dante, a cura di G. Chiecchi, Roma-Padova, Editrice Antenore, 2009
No full textRecensione allo studio di Giuseppe Chiecchi su Vincenzo Borghini, relativamente alla difesa di quest'ultimo della lingua di Dante nel secolo XV
Codice Vaticano Rossiano 947: il "Decameron" di Domenico Caronelli
No full textStudio del cod. Vaticano Rossiano 947, copia del Decameron vergata a Conegliano nel 1395 da Domenico Caronelli, che ricostruisce: la storia della famiglia del copista e la sua biografia; la fattura materiale e il contenuto del codice; i rapporti filologici con i due più importanti testimoni della tradizione manoscritta del Decameron (cod. Parigino Italiano 482 e cod. Hamilton 90), mediante una duplice collazione concernente un quarto dell’opera. Successivamente si illustrano i rapporti fino ad ora sconosciuti con i codici Italiano X, 14 (6950) della Biblioteca Marciana e 952 della Biblioteca del Seminario Patriarcale di Venezia, scoprendo l’esistenza di una tradizione di area veneta, che in parte spiega la natura dei singolari interventi operati dal Caronelli sul testo del Boccaccio.Study about codex Vaticano Rossiano 947, copy of the Decameron, transcribed in Conegliano in 1395 by Domenico Caronelli, reconstructing: the copyst’s family history and his biography; the material manufacture and content of the codex; the philological relations with the two most important witness of the manuscript tradition relatively Decameron (cod. Parigino Italiano 482 e cod. Hamilton 90), by means of a dual collating in relation to a quarter of the work. Unknown connections are shown with the manoscripts Italiano X, 14 (6950) of the Biblioteca Marciana and 952 of Biblioteca of Seminario Patriarcale in Venice, proving the existence of a tradition in the Veneto area, partly explaining the nature of Caronelli’s particular interventions in Boccaccio’s work
Carteggio Giovanni Pascoli - Alfredo Caselli (1898-1912) a cura di Francesca Florimbii, Bologna, Patron, 2010 (Edizione nazionale delle opere di Giovanni Pascoli. Carteggi; 3)
No full textL'opera ricostruisce l'intero carteggio relativo alla corrispondenza tra Giovanni Pascoli e l'amico commerciante, una corrispondenza che è testimonianza del carattere del poeta e ne rivela le debolezze, le paure e le difficoltà di fronte alla vita quotidiana
Micro-markers: microRNAs in cancer diagnosis and prognosis
No full textMolecular diagnostics in cancer should provide the highest specificity and sensitivity in classification, prognostic stratification and early detection. MicroRNAs could contribute to hit the mark, or at least to come nearer, in virtue of their cancer-specific expression and stability. Indeed, differently from other RNA classes, microRNAs can be detected and quantified not only in frozen tissues, but also in formalin fixed paraffin-embedded tissues as well as serum/plasma samples. Thus, microRNA studies have quickly moved from research on the molecular basis of cancer to areas of clinical application. This review summarizes the potential role of microRNAs as molecular markers for cancer classification, prognostic stratification and drug-response prediction. It also summarizes their potential as circulating markers and cancer-predisposing genes. If we consider that studies on microRNAs in cancer therapy have already given important contributions, microRNAs already had an impact in all cancer areas. Whether this will translate into clinical applications is still too early to say. However, in the diagnostic field, microRNAs may already represent an improvement over presently available approaches: for example, their expression profile is effective in the identification of metastasis tissue of origin. In addition, circulating microRNAs are expected to provide improved specificity and/or sensitivity over presently available markers
Progetto triennale AIRC (MFAG 2011). Titolo: Circulating microRNAs as cancer-specific biomarkers
No full textAn important area in cancer research is the identification of tumor markers that might improve the early diagnosis of cancer patients and reduce morbidity and mortality rates associated with the disease. Recently, microRNAs (miRNAs) have been added to the panel of plasma-detected biomarkers thanks to their cancer-specificity, high stability and the availability of assays able to quantify their level.
In addition, recent studies report the association between the deregulated expression of several miRNAs and the response to treatments, prognosis and metastatic potential of malignancies. The determination of miRNAs expression in cancerous tissue, however, requires the availability of tissue specimens which may represent a problem in non surgically treated patients. The availability of blood-circulating markers might overcome the limits of tissue sampling being non invasive and repeatable over time.
Using a microarray technology, we hereby propose to identify different sets of plasma miRNAs whose levels are indeed associated with each of the following cancer types: breast, gastrointestinal (gastric and colorectum), lung, pancreatic, melanoma, thyroid and hepatocellular. Circulating cancer-specific miRNAs will be compared to the miRNA profile of control populations (age-matched healthy subjects or cirrhotic patients for hepatocellular carcinoma). Cancer-associated miRNAs will be validated in an independent population of patients using a quantitative approach; their correlation with clinical-pathological information will be also investigated.
Finally, miRNA levels will be monitored after surgery, according to patients follow-up schedules, in order to verify if they can possibly predict cancer recurrence.
This study aims therefore (i) to assay plasma levels of circulating miRNAs as possible markers of increased risk of cancer development, (ii) to define a profile of circulating miRNAs characterizing cancers at different stages and (iii) to assess a panel of circulating miRNAs as possible early predictors of cancer recurrence after curative treatments.
If this project will be successful, a new panel of sensitive and specific biomarkers for cancer diagnosis and prognostic risk assessment will be available
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