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Basement faults as a control on crustal architecture and topography at the transiton between Northern Victoria Land and the Wilkes Subglacial Basin (East Antarctica)
No full textMajor terrane bounding and intra-terrane faults have been recognised from extensive geological investigations
within the partially exposed basement rocks of Northern Victoria Land (NVL) in East Antarctica. These major
fault systems were active during the Ross Orogen and are related to several phases of Cambrian to Ordovician age
subduction and crustal accretion along the active paleo-Pacific margin of Gondwana. Here we compile and analyse
enhanced aeromagnetic and gravity anomaly images from NVL to the eastern margin of the Wilkes Subglacial
Basin (WSB) to image the subglacial extent and tectonic architecture of these major fault systems within the base-
ment. Our two-dimensional magnetic and gravity models predict that linear and long-wavelength magnetic lows
and residual Bouguer gravity highs over the central Wilson Terrane reflect several-km thick inverted sedimentary
basins of early Cambrian(?) age. Tectonic inversion occurred primarily along major thrust faults, formed in a dom-
inantly transpressional late stage of the Ross Orogen. Further west, a major fault system flanks the eastern margin
of the Wilkes Subglacial Basin, and connects to the previously interpreted Prince Albert Fault System to the south.
This fault system can now be recognised as lying west of the Exiles Thrust fault system, rather than represent-
ing its southern continuation (e.g. Ferraccioli and Bozzo, 1999, JGR). Relatively thin sheets of mylonitic sheared
granitoids and possible ultramafic lenses are modelled as being associated with the late-Ross (ca 480 Ma) Exiles
Thrust fault system, while significantly larger and thicker batholiths were emplaced along the Prince Albert Fault
System. Recent zircon U–Pb dating over small exposures of gabbro-diorites within the Prince Albert Mountains to
the south lead us to propose that this part of the magmatic arc was emplaced along a major pre-existing fault during
an earlier phase of subduction (>520 Ma or older). This attests to a long-lived and composite magnatic arc system,
which likely migrated in response to changes in the geometry and dynamics of the subduction system, much like
several modern arc systems. Whether the Prince Albert Fault System was indeed a major arc-continent suture in
early Cambrian times, as proposed by Ferraccioli et al., 2002 (GRL), or simply an arc to back-arc, or alternatively
an arc to forearc transition, remains to be more fully understood. Irrespective of possible alternative models for
the original tectonic setting of these faults during the Ross Orogen, we show by combining aeromagnetic inter-
pretation and topographic lineament analyses that these major terrane bounding and intra-terrane basement faults
exerted a key influence both on the tectonic segmentation of the Transantarctic Mountains into discrete Cenozoic
fault-blocks and on the subglacial topography along the eastern margin of the WSB
Costantino ed il rapporto tra imperium e sacerdotium nella ricerca storiografica dei Gesuiti Riceputi e Farlati (1720-1773). I codici ritrovati del Museo Illirico = http://www.dirittoestoria.it/4/Tradizione-Romana/Ferraccioli-Giuraudo-Constantino-imperium-sacerdotium.htm [estratto a stampa, 37 pp.]
No full textMulta et varia. Studi offerti a Maria marcella Ferraccioli e Gianfranco Giraudo
No full textStudi di slavistica, iranistica, storia di Venezia, storia della Romania dedicati ai proff. G. Giraudo e M. M. Ferraccioli
Preserved Ross-age(?) root beneath the Transantarctic Mountains and origin of the thinner crust beneath the northern Wilkes Subglacial Basin
No full textThe Wilkes Subglacial Basin, in the hinterland of the Transantarctic Mountains, represents one of the least un-
derstood continental-scale features in Antarctica. Aeromagnetic data suggests that this basin was imposed on a
much earlier Ross age back arc region that developed along the former active margin of the East Antarctic Craton
(Ferraccioli et al., 2009, Tectonophysics). However, the deeper crustal structure of the basin and its relation with
tectonic evolution remains both disputed and poorly constrained. Here, we present new airborne gravity data that
reveal the crustal architecture of the northern Wilkes Subglacial Basin. Our gravity models indicate that the crust
under the northern Wilkes Subglacial Basin is likely to be 30–35 km thick, i.e. 5–10 km thinner than imaged under
the adjacent Transantarctic Mountains, and
15 km thinner than predicted from some previous flexural and pas-
sive seismic models beneath the southern Wilkes Subglacial Basin region. We infer that crustal thickening under
northern Victoria Land reflects Ross-age (ca 500 Ma) orogenic events and accretion, followed by partial preserva-
tion of the orogenic root since then, as opposed to reflecting the edge of a Mesozoic plateau, which has previously
been inferred to have occupied West Antarctica (Bialas et al. 2007, Geology). Airy isostatic anomalies along both
flanks of the Wilkes Basin reveal major inherited tectonic structures, which likely controlled the basin location and
hence support aeromagnetic interpretations of the Wilkes Subglacial Basin as a structurally controlled basin. The
positive anomaly along the western margin of the basin appears to define the tectonic boundary between the East
Antarctic Craton and the Ross Orogen, and the anomaly along its eastern flank is interpreted as reflecting high-
grade and denser rocks of the central Wilson Terran,e with respect to lower grade meta-sediments and magmatic
arc rocks of the western Wilson Terrane and Wilkes Basin region. Our forward models indicate that the crust is
5 km thinner beneath the northern Wilkes Basin, compared to formerly contiguous segments of the Delamerian
Orogen in south-eastern Australia. We put forward four possible explanations for the thinner crust we modelled
beneath the northern Wilkes Subglacial Basin: i) back-arc basin formation or orogenic collapse processes, coupled
with major crustal-scale tectonic segmentation within the Ross
n
Delamerian orogens, ii) Jurassic to Cretaceous
intraplate extension in East Antarctica, prior to later break-up between Australia and East Antarctica, iii) major
glacial erosion within the Wilkes Subglacial Basin since East Antarctic Ice Sheet initiation, ca 34 Ma, or most
likely- iv) a combination of these tectonic and erosional processes and their associated isostatic response
Nonparametric methods for complex spatial domains: density estimation and hypothesis testing
Full text linkThe analysis of not only big, but increasingly complex data represents a thriving branch of statistics. Modern applications ranging from neuroscience, geo-sciences, astronomy and engineering pose stimulating challenges to classical statistics and require the development of novel methodologies. In this thesis we propose nonparametric approaches to density estimation and hypothesis testing over multidimensional domains with complex shapes. The synergy of ideas and techniques from applied mathematics, numerical analysis and statistics allows us to obtain flexible and efficient tools. The thesis is organized in three main threads. The first considers the problem of density estimation over multidimensional domains with complex shapes. Here we combine a nonparametric likelihood approach with a regularization involving partial differential operators. The second thread examines two sample hypothesis testing. Inspired by the first part, we take advantage of permutation procedures to develop high dimensional
multinomial tests for distributions defined over complex domain. The last thread moves toward a parallel direction, that is the study of hypothesis testing procedures for semiparametric spatial regression models. After a careful analysis of their theoretical properties, we propose a nonparametric randomization approach to test the linear
components of such models
Extent and architecture of major fault systems between northern Victoria Land and the eastern margin of the Wilkes Subglacial Basin (East Antarctica)
No full textTerrane bounding and intra-terrane faults of the Ross Orogen in East Antarctica are linked to several phases of Cambrian to Ordovician age subduction and accretion along the active paleo-Pacific margin of Gondwana. Here we compile and analyse new enhanced aeromagnetic anomaly images over the Northern Victoria Land (NVL) segment of the Ross Orogen and the eastern margin of the Wilkes Subglacial Basin (WSB) that help constrain the extent and structural architecture of these fault systems and enable us re-assess their tectonic evolution. Long-wavelength magnetic lows and residual Bouguer gravity highs are modelled as several-km thick inverted sedimentary basins of early Cambrian(?) age. Tectonic inversion occurred along major thrust faults during the late stages of the Ross Orogen, forming a major high-grade pop-up structure within the central Wilson Terrane, flanked by lower grade rocks. The Prince Albert Fault System can now be recongnised as being located to the west of the Exiles Thrust fault system rather than representing its southern continuation. Relatively thin sheets of mylonitic sheared granitoids and possible ultramafic lenses are associated with the late-Ross (ca 480 Ma) Exiles Thrust fault system, while significantly larger and thicker batholiths were emplaced along the Prince Albert Fault System. Recent zircon U-Pb dating over small exposures of gabbro-diorites within the Prince Albert Mountains to the south lead us to propose that this part of the magmatic arc was emplaced during an earlier phase of subduction (~520 Ma or older?), compared to the late-Ross intrusions to the east. Whether the Prince Albert Fault System was indeed a major cryptic suture in early Cambrian times (Ferraccioli et al., 2002, GRL) remains speculative, but possible. Our aeromagnetic interpretation leads us to conclude that these inherited terrane bounding and intra-terrane fault systems of the Ross Orogen exerted a key influence on Cenozoic tectonic blocks and faults of the Transantarctic Mountains, and that the eastern margin of the WSB adjacent to NVL was also strongly controlled by a complex array of major intraplate strike-slip fault systems
Biosimilars in rheumatology: pharmacological and pharmacoeconomic issues
No full textRheumatoid arthritis (RA) societal costs are high because the disease may cause not only restricted joint mobility, chronic pain, fatigue, and functional disability, but also psychological distress. Direct health care costs represent about one-fourth of all costs and are prevalently represented by in-patient care expenditures. The introduction of biologics disease-modifying anti-rheumatic drugs (B-DMARDs), has really changed the perspectives of the patients not fully responding to conventional DMARDs, but the direct costs for drugs has really modified the expenditure for this disease and many other diseases, i.e. psoriatic arthritis, spondyloarthropathies. Increasing pressure for lower cost versions of biological medicines, the scientific technology (particularly analytical technology) that continues to improve will lead to the introduction through reverse ingeneering of biosimilar drugs in rheumatology. The hope is to provide cost savings, which may broaden access to biopharmaceuticals and stimulate further research. The need for patients to have a biosimilar product, with comparable efficacy and safety, will be discussed in this paper along with all the possible issues that will govern the assessment of the bioequivalence and of the interchangeability
[Class IV-G and IV-S lupus nephritis, interstitial infiltrates and prognosis: state of the art and unmet medical needs]
No full textNephritis in systemic lupus erythematosus is one of the manifestations of organ damage in this autoimmune disease. Class IV is the most ominous among the classes of nephritides and there are conflicting reports on whether class IV-G lupus nephritis differs from class IV-S as defined by the International Society of Nephrology and the Renal Pathology Society (ISN/RPS) in terms of kidney and patient survival. There is, however, general agreement that 15-30% of patients with class IV nephritis do not reach remission and that a similar percentage (15-30%) of those reaching remission relapses. The presence of interstitial nephritis may be one of the determinants of a poor disease course. In fact, in recent years new data have emerged regarding the role of interstitial infiltrates in determining a poor outcome, but until now no data have been gathered on the differentiation of outcomes among class IV-G or IV-S with and without infiltrates
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