2,092 research outputs found
Effect of Bj-PRO-7a peptide on cardiac remodeling in hypertensive rats
No full textBj-PRO-7a, a proline-rich oligopeptide isolated from Bothrops jararaca snake
venom, was able to reduce blood pressure and heart rate in hypertensive
animals. However, it is not yet known whether this peptide may have beneficial
effects on cardiac remodeling. Herein, we evaluate the effect of the Bj-PRO-7a
in spontaneously hypertensive rats. Normotensive (Wistar) and spontaneously
hypertensive (SHR) rats were divided into 3 groups: 1) Wistar treated with 0.9%
saline, s.c.; 2) SHR treated with 0.9% saline, s.c.; and 3) SHR treated with BjPRO-7a
(71 nmol/Kg/day, s.c.). The animals were treated during 28 days. The
systolic blood pressure was weekly measured by tail-cuff plethysmography. At
the end of the treatment, cardiac function was evaluated in isolated perfused
heart preparation. The ventricular mass index was calculated by the ratio
between the left ventricular weight and tibia length. The cardiomyocyte diameter
and interstitial and perivascular fibrosis of the left ventricle were evaluated using
the Picrossirius staining. The detection of collagen III deposition was evaluated
by immunofluorescence. Fibroblast proliferation were assessed by
immunohistochemistry to detect proliferating cell nuclear antigen (PCNA). The
expression of catalase, SOD and ERK1/2, MMP-2 and MMP-9 was assessed
by Western Blot. In our protocol, the Bj-PRO-7a was unable to reduce the
systolic blood pressure of the SHRs. However, this peptide attenuated the
development of the cardiomyocyte hypertrophy in these animals. Additionally,
the deposition of the interstitial and perivascular fibrosis in SHR was
significantly reduced by the treatment with Bj-PRO-7a. This peptide did not alter
the collagen III deposition in hypertensive rat hearts. The Bj-PRO-7a reduced
positive PCNA-labeled fibroblasts. The expression of catalase, SOD and
ERK1/2 was significantly increased in SHR, but the Bj-PRO-7a attenuates this
increase. The expression of MMP-2 and MMP-9 was not different in SHR
hearts, but the Bj-PRO-7a increased the expression of the MMP-2 in the heart
of these animals. Our findings demonstrate that the Bj-PRO-7a reduced the
pathological cardiac remodeling through mechanism mediated by inhibition of
the ERK1/2 and increasing MMP-2 expression. This data suggest that the Bj-
xxiii
PRO-7a could have a potential therapeutic for the treatment of cardiac
diseases.O Bj-PRO-7a é um heptapetídeo pertencente à família de oligopeptídeo rico em
prolina isolado do veneno da serpente Bothrops jararaca. Estudos in vivo,
mostraram que a administração aguda do heptaptídeo é capaz de reduzir a
pressão arterial e a frequência cardíaca de animais hipertensos. Ainda pouco
estudado e considerando os efeitos antihipertensivo e bradicardico, avaliamos
o remodelamento cardíaco de animais hipertensos tratados com o Bj-PRO-7a.
No presente estudo, foram utilizados ratos normotensos (Wistar) e
espontaneamente hipertensos (SHR) que foram separados em 3 grupos
experimentais e receberam: 1) Wistar, 0,9% NaCl, (150 µl/dia, s.c.); 2) SHR,
0,9% NaCl, (150 µl/dia, s.c.); e 3) SHR tratado com Bj-PRO-7a (71 nmol/Kg/dia,
s.c.). As injeções (in bolus) foram repetidas diariamente durante 28 dias.
Durante o tratamento, os animais tiveram a pressão arterial sistólica (PAS)
mensurada semanalmente, pelo método não invasivo de plestimografia. No
final do tratamento, a função cardíaca foi avaliada pelo método de Langendorff.
A hipertrofia cardíaca de SHRs foi avaliada com análise dos seguintes
parâmetros: índice de massa ventricular, diâmetro do cardiomiócito, fibrose
intersticial e perivascular, colágeno III, proliferação de fibroblastos e expressão
da catalase, SOD, ERK1/2, MMP-2 e MMP-9. Nossos resultados mostram que
o tratamento crônico com Bj-PRO-7a não promoveu alterações importantes na
PAS de SHRs. No entanto, este peptídeo atenuou o desenvolvimento da
hipertrofia dos cardiomiócitos de SHRs. Apesar do Bj-PRO-7a não ter alterado
a deposição de colágeno III, foi capaz de reduzir a deposição de colágeno
intersticial e perivascular, bem como, a proliferação de fibroblastos em SHR. A
linhagem de ratos hipertensos, tem expressão de CAT, SOD e ERK1/2
significativamente maior do que em ratos normotensos. O Bj-PRO-7a atenuou
o aumento da expressão dessas enzimas / proteínas. Por outro lado, aumentou
a expressão da MMP-2 ativa nos corações de ratos hipertensos. Nossos
resultados mostram que o Bj-PRO-7a reduziu o remodelamento cardíaco
patológico através de mecanismos mediados pela inibição da ERK1/2 e
aumento da expressão da MMP-2. Dessa forma, os resultados sugerem que o
Bj-PRO-7a apresenta um potencial terapêutico para desenvolvimento de
fármacos para o tratamento de doenças cardiovasculares
Oregon serious crime survey
No full textauthor, survey administration and data processing: Stan WoodwellCaption titleThis archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposesBureau of Justice Statistics, United States Department of Justice 80-BJ-CX-K009 82-BJ-CX-0002 82-BJ-CX-0014Mode of access: Internet from the Oregon Government Publications CollectionText in Englis
BJ-TSA-9, a Novel Human Tumor-Specific Gene, Has Potential as a Biomarker of Lung Cancer
No full textAbstractUsing bioinformatics, we have identified a novel tumorspecific gene BJ-TSA-9, which has been validated by Northern blot analysis and reverse transcriptionpolymerase chain reaction (RT-PCR). BJ-TSA-9 mRNA was expressed in 52.5% (21 of 40) of human lung cancer tissues and was especially higher in lung adenocarcinoma (68.8%). To explore the potential application of BJ-TSA-9 for the detection of circulating cancer cells in lung cancer patients, nested RT-PCR was performed. The overall positive detection rate was 34.3% (24 of 70) in peripheral blood mononuclear cells (PBMCs) of patients with various types of lung cancers and was 53.6% (15 of 28) in PBMCs of lung adenocarcinoma patients. In combination with the detection of two known marker genes SCC and LUNX, the detection rate was increased to 81.4%. A follow-up study was performed in 37 patients after surgical removal of tumor mass. Among nine patients with persistent detection of two to three tumor marker transcripts in PBMCs, six patients had recurrence/metastasis. In contrast, 28 patients with transient detection of one tumor marker or without detection of any tumor marker were all in remission. Thus, BJ-TSA-9 may serve as a marker for lung cancer diagnosis and as a marker, in combination with two other tumor markers, for the prediction of the recurrence and prognosis of lung cancer patients
Bj: Physical Parts Bj
No full textComments are invited and should be directed to the author at the address listed below. Please do not reproduce in any way without the permission of the authors. A complet
Estimation of the number of periodic orbits
No full textThe main theme of this paper is to estimate, for self-maps f : X --> X of compact polyhedra, the asymptotic Nielsen number N-infinity(f) which is defined to be the growth rate of the sequence {N(f(n))} of the Nielsen numbers of the iterates of f. The asymptotic Nielsen number provides a homotopy invariant lower bound to the topological entropy h(f). To introduce our main tool, the Lefschetz zeta function, we develop the Nielsen theory of periodic orbits. Compared to the existing Nielsen theory of periodic points, it features the mapping torus approach, thus brings deeper geometric insight and simpler algebraic formulation. The important cases of homeomorphisms of surfaces and punctured surfaces are analysed. Examples show that the computation involved is straightforward and feasible. Applications to dynamics, including improvements of several results in the recent literature, demonstrate the usefulness of the asymptotic Nielsen number.MathematicsSCI(E)19ARTICLE1151-18517
Desain Interior Hotel BJ. Perdana Berkonsep Modern dengan Sentuhan Budaya Pasuruan
No full textHotel merupakan salah satu bentuk akomodasi yang dikelola secara komersial, yang disediakan bagi setiap orang untuk memperoleh pelayanan, penginapan berikut makanan dan minuman. Provinsi Jawa Timur, sebagai salah satu wilayah tujuan wisata di Indonesia, menawarkan berbagai macam obyek wisata baik obyek wisata alam, budaya, maupun buatan. Salah satu daerah tujuan wisata di Jawa Timur yang menawarkan keindahan alam yaitu pemandangan alam pegunungan yang salah satunya ada di Kota Pasuruan. Oleh karena itu, diperlukannya sarana akomodasi yang baik secara kualitas dan kuantitas. BJ. Perdana merupakan salah satu hotel terbaik di Kota Pasuruan, letak dari hotel tersebut cukup strategis dan banyak diminati oleh pengunjung. Namun sayang interior hotel tersebut belum tertatat cukup baik, dan tidak menyimbolkan bahwa hotel tersebut berada di kota Pasuruan.
Pada tugas akhir ini penulis meredsain hotel BJ. Perdana berkonsep modern dengan sentuhan budaya Pasuruan. Penulis juga memberikan informasi mengenai budaya yang ada di kota Pasuruan dengan cara di tuangkan dalam desain interiornya. Dengan menerapkan beberapa bentukan hasil budaya serta warna yang menjadi ciri khas kota Pasuruan. Ini bertujuan agar pengunjung tau akan budaya dan ciri khas dari Kota Pasuruan itu sendiri. Dan juga dapat menjadikan media promosi serta ikut andil dalam program pemerintahan Kota Pasuruan.
Dalam mendesain interior restoran diperlukan metode desain. Metode yang digunakan yaitu pengumpulan data, analisa data, konsep dan pengembangan desain, serta desain akhir. Hasil yang diharapkan adalah sebuah desain interior hotel yang menunjang kebudayaan setempat agar dapat melestarikan budaya setempat serta menjadi media promosi kepada para wisatawan yang berkunjung.
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The hotel is a form of commercially managed accommodation, provided for everyone to get service, with food and drinks. East Java Province, as one of the tourist destinations in Indonesia, offers a variety of attractions both natural attractions, culture, and artificial. One of the tourist destinations in East Java that offers natural beauty that is the natural scenery of the mountains one of which is in Pasuruan. Therefore, the need for good accommodation facilities in quality and quantity. BJ. Perdana is one of the best hotels in Pasuruan City, the location of the hotel is quite strategic and much in demand by visitors. But unfortunately the interior of the hotel has not been recorded well enough, and does not symbolize that the hotel is located in the city of Pasuruan. In this final project the author redesigned the hotel BJ. Perdana modern concept with a touch of Pasuruan culture. The author also provides information about the existing culture in the city of Pasuruan by way of pour in interior design. By applying some formation of cultural and color results that characterize the city of Pasuruan. It aims to let visitors know the culture and characteristics of Pasuruan City itself. And also can make the media campaign and take part in government program of Pasuruan City. In designing the interior design method is required. The method used is data collection, data analysis, concept and design development, and final design. The expected result is a hotel interior design that supports the local culture in order to preserve the local culture and become a media campaign to the tourists who visit
"AVALIAÇÃO DE GENÓTIPOS DE FEIJOEIRO COMUM DOS GRUPOS ROXO E JALO, NA ÉPOCA DE INVERNO, EM UBERLÂNDIA – MG"
No full text"O objetivo deste trabalho foi avaliar o comportamento agronômico de diversos genótipos de feijoeiro comum (Phaseolus vulgaris L.) para o lançamento de futuros cultivares comerciais. O experimento foi instalado no município de Uberlândia-MG, na Fazenda Água Limpa, de propriedade da Universidade Federal de Uberlândia, no período de julho a outubro de 2005, na época de inverno, onde foram avaliados quanto ao número de vagens por planta, número de grãos por vagem, peso de 100 grãos e produtividade. O delineamento experimental utilizado foi de blocos casualizados (DBC), com três repetições e vinte e três tratamentos (genótipos) de feijoeiro dos Grupos Roxo e Jalo (ROXO 90, VR-3, VR-12, BRS TIMBO, BRS PITANGA, CNFR 7847, CNFR 8149, CNFRX 8144, CNFRX 10531, CNFRX 10535, JALO EEP-558, RADIANTE, BJ-1, BJ-2, BJ-3, BJ-4, BJ-5, BJ-6, BJ-7, BJ-8, CNFRJ 10556, CNFRJ 10564 e CNFRJ 10571), pertencentes aos ensaios regionais de Valor de Cultivo e Uso – VCU da Embrapa Arroz e Feijão, totalizando sessenta e nove parcelas. Cada parcela foi constituída de quatro linhas com quatro metros de comprimento, e espaçadas em 0,50 m entre si. A área total de cada parcela foi de 8 m2 e a área útil de 4 m2, pois foram colhidas somente as duas linhas centrais. Os resultados obtidos permitiram concluir que não houve diferença significativa para número de vagens por planta, mas o genótipo BRS PITANGA foi o que mais se destacou quando feita a comparação relativa, tendo média 36,5% maior que a testemunha ROXO 90 e 13,5% maior que a testemunha JALO EEP-558. Os genótipos CNFR 8149 e CNFRX 10535 apresentaram maior número de grãos por vagem, ambos 3,6% acima da testemunha ROXO 90, e 11,8% acima da testemunha JALO EEP-558. O genótipo BRS RADIANTE apresentou o maior peso de 100 grãos, com 96,5% acima da testemunha ROXO 90 e 13,7% acima da testemunha JALO EEP-558. Não houve diferença significativa entre os tratamentos para produtividade, sendo o genótipo BJ-4 com 2.881,6 kg ha-1 o mais produtivo.
Avaliação de genótipos de feijoeiro comum dos grupos roxo e jalo, na época de inverno, em Uberlândia - MG
No full textO objetivo deste trabalho foi avaliar o comportamento agronômico de diversos genótipos de feijoeiro comum (Phaseolus vulgaris L.) para o lançamento de futuros cultivares comerciais. O experimento foi instalado no município de Uberlândia-MG, na Fazenda Água Limpa, de propriedade da Universidade Federal de Uberlândia, no período de julho a outubro de 2005, na época de inverno, onde foram avaliados quanto ao número de vagens por planta, número de grãos por vagem, peso de 100 grãos e produtividade. O delineamento experimental utilizado foi de blocos casualizados (DBC), com três repetições e vinte e três tratamentos (genótipos) de feijoeiro dos Grupos Roxo e Jalo (ROXO 90, VR-3, VR-12, BRS TIMBO, BRS PITANGA, CNFR 7847, CNFR 8149, CNFRX 8144, CNFRX 10531, CNFRX 10535, JALO EEP-558, RADIANTE, BJ-1, BJ-2, BJ-3, BJ-4, BJ-5, BJ-6, BJ-7, BJ-8, CNFRJ 10556, CNFRJ 10564 e CNFRJ 10571), pertencentes aos ensaios regionais de Valor de Cultivo e Uso - VCU da Embrapa Arroz e Feijão, totalizando sessenta e nove parcelas. Cada parcela foi constituída de quatro linhas com quatro metros de comprimento, e espaçadas em 0,50 m entre si. A área total de cada parcela foi de 8 m2 e a área útil de 4 m2, pois foram colhidas somente as duas linhas centrais. Os resultados obtidos permitiram concluir que não houve diferença significativa para número de vagens por planta, mas o genótipo BRS PITANGA foi o que mais se destacou quando feita a comparação relativa, tendo média 36,5% maior que a testemunha ROXO 90 e 13,5% maior que a testemunha JALO EEP-558. Os genótipos CNFR 8149 e CNFRX 10535 apresentaram maior número de grãos por vagem, ambos 3,6% acima da testemunha ROXO 90, e 11,8% acima da testemunha JALO EEP-558. O genótipo BRS RADIANTE apresentou o maior peso de 100 grãos, com 96,5% acima da testemunha ROXO 90 e 13,7% acima da testemunha JALO EEP-558. Não houve diferença significativa entre os tratamentos para produtividade, sendo o genótipo BJ-4 com 2.881,6 kg ha-1 o mais produtivo
Assessment Risk Factors in Poisoning Patients with Altered Consciousness Status
No full textBackground & Objectives: One of the limitations in management of patients suffering from
decreased level of consciousness due to drug poisoning is the inability to interview the patient.
The aim of the study was to compare characteristics of the two subgroups of these patients; those
who had a suicidal attempt history with others.
Methods: In this cross-sectional study, 19 patients with suicidal attempt history and 66 patients
without this history were selected among patients who were admitted for drug poisoning to
referral poisoning hospitals in Tehran, Iran, in August, September and October 2009. All of them
had decreased level of consciousness due to unknown drug poisoning. Demographics, poisoning
characteristics, past medical history and substance use history of the patients were recorded.
Results: Different between previous history of suicide action with drug material decreased level
of consciousness caused by poisoning, was significantly (p=0.04). Mental disease (p > 0.01),
number of tablets consumed (p=0.02), interval between drug consumption and emergency forces
to reach the place (p= 0.021), described in deliberate self poisoning patients (Self Poisoning)
(p=0.001), decreased level of consciousness grade (p=0.046), U.S. fail initial level of
consciousness after emergency measures (p=0.02) and the need for health care and advanced next
(p= 0.013) in patients with decreased level of consciousness with a history of previous suicide
compared with other group were higher. Significant difference between the two age groups
(P> 0.05), gender and history of illegal drug use (P> 0.05) did not exist.
Conclusion: According to these findings, when dealing with patients suffering from decreased
level of consciousness due to unknown drug poisoning, paying attention to history of suicidal
attempts in these patients can help medical professionals in determining more effective treatment
options for them. Medical staff should also record previous suicide as a risk factor in the risk
assessment to consider the disease.
Key words: Drug poisoning; Suicidal Attempt; Risk assessmen
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