109 research outputs found
Optical coherence tomography angiography (OCTA) applications in ocular oncology
Get PDFOptical coherence tomography angiography (OCTA) is a revolutionary method in the visualization of the vascular system in different retinal and choroidal layers. During the last 4 years since the commercial availability of different OCTA devices, attempts have been made to utilize this technology in various aspects of ocular oncology from the differentiation of benign and malignant lesions to assisting in evaluation of post-treatment complications, such as radiation retinopathy. However, current OCTA technology is restricted by various artefacts and inherent limitations, some of which are more pronounced in the presence of elevated tumoural lesions. Imminent advancements in OCTA systems and image acquisition processes promise a great potential for application of OCTA in ocular oncology. © 2020, The Author(s), under exclusive licence to The Royal College of Ophthalmologists
The Application of OCTA in Assessment of Anti-VEGF Therapy for Idiopathic Choroidal Neovascularization
Get PDFPurpose. To assess the morphology of idiopathic choroidal neovascularization (ICNV) by optical coherence tomography angiography (OCTA) and determine the therapeutic effects of intravitreal antivascular endothelial growth factor (anti-VEGF). Method. Patients with naive ICNV were assessed by spectral domain optical coherence tomography (SD-OCT) and OCTA in this observational study. The timing of observation was before treatment, 1 day after treatment with intravitreal anti-VEGF injection, and 1 month after the treatment. The central retina thickness (CRT) on SD-OCT, selected CNV area, and flow area on OCTA were measured. Results. A total of 17 eyes from 17 patients with ICNV were included in this study. OCTA showed visible irregular choroidal neovascularization with “tree-in-bud” form on outer retinal layer. After treatment, as well as in the 1-day follow-up, CNV decreased in size from the periphery, and the vessel density was reduced. As shown on OCTA, the selected CNV area and flow area were significantly reduced compared to pretreatment. The rate of CNV vessel area changes was higher on OCTA than the changes in CRT on SD-OCT at 1-day and 1-month follow-up. Conclusion. Intravitreal injection of anti-VEGF is effective for idiopathic choroidal neovascularization, and the treatment outcomes are observable after 1 day. OCTA provides a useful approach for monitoring and evaluating the treatment of intravitreal anti-VEGF for CNV
The synthesis and properties of some well-defined fluorinated polymers
Get PDFThis thesis describes studies directed to the ring opening metathesis polymerisation (ROMP) of some fluorinated compounds using a range of well-defined initiators. Chapter 1 reviews some general aspects of olefin metathesis and ring opening metathesis polymerisation of relevance to the work described in this thesis. Topics such as piezo- and pyro-electricity and optical and electrical properties of conjugated polymers are introduced and these receive more detailed attention later in the thesis. Chapter 2 describes the synthesis, characterisation and properties of . poly(bis(trifluororaethyl)norbomadiene) in detail. The use of various initiating systems that have been used previously and the effect they have on the tacticity of the resulting polymer raicrostructure are discussed. The latter part of this chapter reviews some of the current thinking concerning the detailed mechanistic aspects of this polymerisation. Chapter 3 reviews attempts directed to an improvement in tacticity control in the synthesis of poly(bis(trifluoromethyl)norbomadiene). The synthesis and activity of the new well-defined initiators used in these studies are reported. It is shown that varying the nature of the ancillary Ligands surrounding the metal centre can have a dramatic influence on the tacticity of the resulting polymer. Chapter 4 reports studies directed to an examination of the limits of the well controlled synthesis of poly(bis(trifluoromethyl)norbornadiene). The syntheses of high trans and high cis, highly tactic poly(bis(trifluoromethyl)norbornadiene samples using well-defined initiating systems are described. It is shown that by varying the monomerinitiator ratio, samples with a wide range of molecular weights can be achieved and these are reported. Chapter 5 describes experiments concerning the ROMP of fluorinated monomers containing six membered rings. In particular ROMP studies of the monomers, 2,3-bis(trifluoromethyl)bicyclo[2.2.2]octa-2,5-diene . and 2,3- (tetrafluorobenzo)bicyclo[2.2.2]octatriene are described finally, Chapter 6 provides a summary of the work reported and outlines some ideas for future studies
MTPL insurance issues in the Latvian market
No full textOCTA ir sauszemes transportlīdzekļu īpašnieku civiltiesiskās atbildības obligātā apdrošināšana. Septiņpadsmit gadu laikā, kopš OCTA apdrošināšana pastāv Latvijā, tikai četrus gadus OCTA nozare ir strādājusi ar peļņu. Bakalaura darba autors ir izvēlējies tēmu „OCTA apdrošināšanas problēmas Latvijas tirgū”, jo vēlējas izpētīt OCTA apdrošināšanas būtību un iemeslus tam, kādēļ OCTA apdrošināšanas nozare regulāri strādā ar zaudējumiem.
Bakalaura darba mērķis ir pamatojoties uz Latvijas OCTA sistēmas un apdrošināšanas nozares darbības datu analīzi, identificēt OCTA apdrošināšanas problēmas Latvijas tirgū un izstrādāt priekšlikumus OCTA nozares darbības uzlabošanai. Lai sasniegtu darba mērķi autors izpētīja OCTA apdrošināšanas sistēmas darbību un tās attīstību Latvijā, kā arī izanalizēja OCTA nozares darbības raksturojošos rādītājus. Izpētes procesā autors identificēja vairākas problēmas OCTA nozarē, un izveidoja secinājumus un priekšlikumus OCTA nozares darbības uzlabošanai.MTPL is motor third party liability compulsory insurance. Over the last seventeen years since MTPL insurance is in Latvia, only for four years MTPL branch has worked with profit. Therefore the author has chosen thesis ”MTPL insurance issues in the Latvian market” to explore the main context of MTPL insurance and reasons for it incurring regular losses.
The objective of this research work is to investigate MTPL insurance issues in the Latvian market and to develop proposals for MTPL branch perfomance improvement based on data analysis of the Latvian MTPL system and insurance branch work. To achieve the defined objectives the author has explored MTPL insurance system’s perfomance and its development in Latvia and has analyzed the characterizing indicators of its performance. Based on the issues identified during the research process the author has made conclusions and proposals for the improvement of the performance of MTPL branch
MTPL insurance problems and their solutions in Latvia
No full textOCTA Latvijā tika ieviesta 1997. gadā. 18 gadu darbības laikā OCTA apdrošināšanas nozare tikai 4 gadus ir strādājusi ar peļņu, turklāt 2015. gada pirmos 9. mēnešus OCTA noslēdza ar 7,3 miljonu eiro zaudējumu, kas ir 2,3 reizes lielāks nekā 2014. gada 9. mēnešos. Darba autors sava temata izvēli pamato ar to, ka ir nepieciešams izpētīt OCTA apdrošināšanas tirgu Latvijā un saprast, kāpēc OCTA tirgus Latvijā strādā ar zaudējumiem. Bakalaura darba mērķis ir izpētīt OCTA nozares darbību un pamatojoties uz datu analīzi noskaidrot kāpēc OCTA nozare 14. gadus ir strādājusi ar zaudējumiem, piedāvāt problēmu risinājumus un izteikt priekšlikumus problēmu novēršanai. Izvirzītā mērķa sasniegšanai autors veica OCTA darbības pamatprincipu izpēti, BM sistēmas izpēti, kā arī veica tirgus analīzi. Noslēgumā autors noskaidroja, ka ir vairākas problēmas OCTA sistēmas darbībā un izdarīja secinājumus, kā arī izteica priekšlikumus OCTA darbības uzlabošanai. ATSLĒGVĀRDI: OCTA; Zaudējumi; LTAB; Analīze; Bonus-MalusMTPL in Latvia was introduced in 1997. In 18 years when MTPL insurance industry works, just 4 years has worked with a profit, while in the 2015 MTPL 9 months ended with a loss of 7.3 million euro, which is 2.3 times higher than in 2014 9 months. The author choose this thesis because there is a need to explore the Latvian MTPL insurance market and understand why the Latvian MTPL market working with a loss. Bachelor work purpose is to investigate the MTPL functioning and based on the analysis of data find out why OCTA industry 14 years has been working with a loss and offer problems solutions and make proposals to remedy the problems. To achieve the goal the author did MTPL system research, Bonus-Malus systems research, and carried out a market analysis. In conclusion, the author found several problems in the MTPL system operation and reached conclusions and made proposals to improve the MTPL functioning. KEYWORDS: MTPL; Losses; LTAB; Analysis; Bonus-Malu
ANALISIS PUTUSAN HAKIM PENGADILAN NEGERI PATI NO 10/Pid.Sus/2013/PN/PT TENTANG TINDAK PIDANA PENYEBARAN KEBENCIAN ATAU PERMUSUHAN MELALUI DUNIA MAYA
Get PDFABSTRAK Sentika Octa Larasati.2016.E0012360. ANALISIS PUTUSAN HAKIM PENGADILAN NEGERI PATI No 10/Pid.Sus/2013/PN/Pt TENTANG TINDAK PIDANA PENYEBARAN KEBENCIAN ATAU PERMUSUHAN MELALUI DUNIA MAYA. Penulisan Hukum (Skripsi). Fakultas Hukum Universitas Sebelas Maret Surakarta Penelitian ini mengkaji dan menjawab permasalahan tentang apa analisis dari putusan hakim Pengadilan Negeri Pati dalam menjatuhkan putusan pidana terhadap pelaku tindak pidana Penyebaran Kebencian atau Permusuhan melalui dunia maya (facebook) pada Putusan No. 10/Pid.Sus/2013/PN.Pt. Penelitian ini apabila dilihat dari tujuannya termasuk jenis penelitian hukum normatif yang bersifat deskriptif. Jenis data yang digunakan adalah data sekunder. Sumber data yang digunakan adalah Putusan Hakim Pengadilan Negeri Pati No.10/Pid.Sus/2013/PN.Pt, Kitab Undang-Undang Hukum Pidana, buku-buku, Peraturan Perundang-Undangan dokumen dan sebagainya yang berkaitan dengan masalah yang diteliti oleh penulis. Teknik pengumpulan data yang dipergunakan yaitu melalui studi kepustakaan yang berkaitan dengan masalah yang diteliti tentang tindak pidana penyebaran kebencian atau permusuhan melalui dunia maya (facebook). Analisis data menggunakan teknik analisis data content analisys dengan pendekatan kualitatif. Berdasarkan penelitian ini diperoleh hasil bahwa analisis dari putusan Hakim Pengadilan Negeri Pati dalam menjatuhkan putusan pidana terhadap pelaku tindak pidana penyebaran kebencian atau permusuhan melalui dunia maya (facebook) Terdakwa Muhammad Rokhisun Bin Ruslan terbukti secara sah dan meyakinkan bersalah melakukan tindak pidana dengan sengaja dan tanpa hak menyebarkan informasi yang ditujukan untuk menimbulkan rasa kebencian atau permusuhan individu dan/atau kelompok masyarakat tertentu berdasarkan atas suku, agama, ras, dan antar golongan (SARA) sebagaimana diatur dalam Pasal 45 ayat (2) juncto Pasal 28 ayat (2) Undang-Undang Nomor 11 Tahun 2008 tentang Informasi dan Transaksi Elektronika. .Unsur-unsur telah terpenuhi semua setelah diperiksa Hakim di persidangan. Pidana yang dijatuhkan oleh Hakim Pengadilan Negeri Pati terhadap Terdakwa Muhammad Rokhisun Bin Ruslam yang melakukan tindak pidana menyebarkan informasi yang dapat menimbulkan rasa kebencian atau permusuhan individu dan/ atau kelompok masyarakat tertentu berdasarkan atas suku, agama, ras, dan antar golongan (SARA) sesuai dalam Pasal 45 ayat (2) juncto Pasal 28 ayat (2) Undang-Undang Nomor 11 Tahun 2008 tentang Informasi dan Transaksi Elektronik relatif lebih ringan dari tuntutan dari Jaksa Penuntut Umum yaitu 4 (empat) tahun dikurangi masa tahanan sebelumnya. Pertimbangan Majelis Hakim adalah karena didalam diri terdakwa tidak terdapat alasan-alasan yang dapat menghapus pidana Terdakwa, baik alasan pemaaf maupun alasan pembenar. Ini dikarenakan Terdakwa belum pernah dihukum dan Terdakwa berusia relatif masih muda diharap dapat memperbaiki kelakuannya. Kata kunci: Putusan, tindak pidana penyebaran kebencian atau permusuhan, dunia maya (facebook) ABSTRACT SENTIKA OCTA LARASATI. 2016. E0012360. ANALYSIS VERDICT OF JUDGES PATI DISTRICT COURT VERDICT NUMBER 10/PID.SUS/2013/PN/PT ABOUT CRIMINAL ACT SPREAD OF HATRED OR HOSTILITY THROUGH CYBERSPACE. LAW WRITING (THESIS). Faculty Of Law Sebelas Maret University. Research review and address concerns about the analysis of the verdict Pati district court in drop down a verdict against crime perpetrators spread hatred or hostility through cyberspace (facebook) as verdict number 10/pid.sus/2013/pn/pt. Research from its goal included normative law research that is descriptive. Type of data used the the secondary data. Source of data used the Pati district court verdict number 10/pid.sus/2013/pn/pt, Criminal Code Procedure, books, regulation of legislation documents, etc. relating to the issues examined by the author. The data collection technique used through study of literature related to the issues examined regarding criminal acts spread of hatred or hostility through cyberspace (facebook). Data analysis used analysis techniques data content analysis with a qualitative approach. Based on this research showed that the analysis of the judge by verdict Pati district court in drop down a verdict against perpetrators of criminal acts spread of hatred or hostility through cyberspace (facebook) the defendant Mohammed Rokhisun Bin Ruslan proven legally and convincingly guilty of committed the crime of intentionally and without authority spread information intended to cause hatred or hostility individual and/ or a particular group of people based on ethnic, religious, racial, and sectarian (SARA) as stipulated out in article 45 paragraph (2) juncto article 28 paragraph (2) of Law number 11 year 2008 concerning on Information And Electronic Transactions. Aspect has fulfilled all the judges in trial after being reviewed. Punishment dropped by the judge of Pati district court against defendant Muhammad Rokhisun Bin Ruslan who committed criminal act of spread information that can engender hatred or hostility individually and/ or specific groups based on ethnicity, religion, race, and sectarian (SARA) according to article 45 paragraph (2) juncto article 28 paragraph (2) of Law number 11 year 2008 concerning on Information And Electronic Transactions relative lighter than the demands of the public prosecutor of 4 (four) years less retention time before. Consideration of the judge because within the defendant there are no reasons to remove punishment defendant, either an excuse or justification. This is because the defendant have not been convicted and relatively young of defendant can be expected to improve his behavior. Keywords: Verdict, Criminal Acts Spread Of Hatred Or Hostility, Cyberspace (Facebook)
Compulsory Civil Liability Insurance of Owners of Vehicles problems in Latvia
No full textBakalaura darbs „Sauszemes Transportlīdzekļu Īpašnieku Civiltiesiskās Atbildības Obligātās apdrošināšanas problēmas Latvijā” tika izveidots, lai izpētītu esošo situāciju OCTA nozarē, jo esošā sistēma strādā Latvijā ar zaudējumiem jau daudzus gadus, kas liecina par to, ka sistēmā pastāv vairākas nopietnas problēmas. Darba mērķis ir izpētīt OCTA sistēmu, izprast esošās problēmas gan no patērētāju puses, gan no apdrošināšanas sabiedrības puses un rast risinājumus atklātajām problēmām. Lai izprastu esošo sistēmu, darba autors izpētīja OCTA likumdošanu, nozares ekonomisko situāciju, kā arī izveidoja aptauju priekš OCTA klientiem un pētīja nozares speciālistu publiskos rakstus. Darba autors veicot pētījumu atklāja vairāk nozīmīgas problēmas, kuras būtu jāuzlabo OCTA sistēmā un pie priekšlikumiem ir izveidojis vairākus ierosinājumus to atrisināšanai.
Bakalaura darba apjoms ir 75 lpp, sastāv no 3 nodaļām ar apakšnodaļām, kurās ir ietvertas 3 tabulas, 11 diagrammas un pievienots 1 pielikums.Thesis „Compulsory Civil Liability Insurance of Owners of Motor Vehicles problems in Latvia” is create to explore the current situation of MTPLI system, because the current system is working with losses for many years that showes that the system have number of serious problems. The aim of the Thesis is explore the MTPLI systems problems,of consumers and insurance companys side, and find solutions to solve the problems. To understand the current situation, author explored MTPLI legislation, the economic situation as well as made a survey for MTPLI consumers and studied public articles with viewpoint of professionals.
The author in the study revealed a few significant problem, which should be improved by MTPLI system. A author made some suggestions how to resolve these problems and wrote down at conclusion part of thesis. In thesis are 75 pages, consisting of three chapters with subchapters, which is included 3 tables, 11 charts and added one annex
Evaluation of the role of optical coherence tomography angiography in monitoring treatment response in patients with neovascular age-;1;related macular degeneration
No full textAim The aim was to assess the role of optical coherence tomography angiography (OCTA) in the diagnosis, assessment of activity, and monitoring the treatment response of choroidal neovascularization secondary to age-related macular degeneration (AMD).
Methods Prospective, interventional case series of eyes that were diagnosed with active neovascular AMD. Spectral-domain optical coherence tomography (SD-OCT) and OCTA were done at baseline after intravitreal antivascular endothelial growth factor (anti-VEGF) treatment to determine OCTA sensitivity in the detection of activity in relation to SD-OCT findings and its specificity following intervention.
Results Twenty-five eyes were included, of which 20 eyes were imaged successfully by OCTA. The diagnostic sensitivity of OCTA in those eyes was found to be 75%, and its sensitivity in the assessment of neovascular activity was 80 and 60%, before and after anti-VEGF therapy, respectively, whereas its specificity after anti-VEGFs therapy was 100%.
Conclusion Although SD-OCT continues to be the gold-standard for noninvasively diagnosing and tracking neovascular AMD treatment response, OCTA may offer a noninvasive option that can support treatment selection throughout follow-up and guide efficient therapeutic approaches. Author contributions: All authors contributed to the construction of idea and question of the research with complete assessment and managements of all the study group. Hebatalla S. Makled: Assessment of the patients with follow-up, doing OCTA for the patients with interpretation, data collection and analysis, and manuscript writing and revision. Ahmad Almabrook Sahban: recruitment of patients with consent acquisition, doing OCTA for the patients, treatment with follow-up of the patients, collection and analysis of data, and manuscript writing. Ayman M Khattab: Patients assessment, decision making and follow-up of patients treatment, OCTA interpretation, collection and analysis of data, and manuscript writing and revision. Ashraf Ahmed Nossair: Patients assessment with follow-up, OCTA interpretation, data collection and analysis, and manuscript writing and revision
Maģistra darbs
No full textMaģistra darbā autore veic pētījumu, kas aptver būtisku OCTA regulējuma problēmjautājumu, kurš konstatēts Latvijas tiesu praksē. Pētījumā ir apskatīts OCTA likuma 35.panta viens no apdrošināšanas gadījumiem, kurā ir noteikts, ka apdrošināšanas atlīdzības izmaksa tiek atteikta gadījumos, kuros zaudējumi transportlīdzeklim ir nodarīti sacensību vai treniņbrauciena laikā. Darbā tiek analizēta transportlīdzekļa lietošanas jēdziena izpratne OCTA likuma regulējuma 35.panta 5.punkta kontekstā ar OCTA Pirmajā Direktīvā ietverto mērķi. Šīs jomas problēma saistīta ar termina starptautisko izmantojamību un pielietojumu civiltiesiskajā apdrošināšanā, Eiropas dalībvalstīm cenšoties vienādot OCTA regulējumu. Pirmkārt, jēdzieni sacensību un treniņbrauciens tiek interpretēti pēc apstākļu sakritības. Otrkārt, ir būtiski sašaurināta Kodificējošās OCTA Direktīvas “transportlīdzekļa” definīcija. Darba noslēgumā autore nonāca pie secinājumiem un izvirzīja savus priekšlikumus. Atslēgvārdi: transportlīdzeklis, apdrošināšana atlīdzības atteikums, sacensību braucieni, treniņbraucieni.In the Master's thesis, the author carries out a research that covers a significant issue of the regulation of MTPL, which has been established in the case-law of Latvian courts. The study deals with one of the insurance cases of Section 35 of the MTPL Law, which stipulates that the payment of insurance indemnity is refused in cases where the loss to the vehicle has been caused during the race competition or training . The paper analyzes the understanding of the concept of vehicle use in the context of Article 35 (5) of the MTPL Law with the objective included in the MTPL First Directive. The problem in this area is related to the international usability and use of the term in civil liability insurance, with the European Member States trying to unify the MTPL regulation. First, the concepts of race and training are interpreted according to the coincidence of circumstances. Secondly, the definition of 'vehicle' in the Codification Directive is significantly reduced. At the end of the work, the author came to conclusions and put forward proposals. Keywords: vehicle, insurance reward refusal, competition racing, training
IMPLEMENTATION OF DIGITAL ENGLISH LEARNING TOWARD JUNIOR HIGH SCHOOL STUDENTS BASED ON MERDEKA CURRICULUM
Get PDFThe purpose of this study is to peer out the results of the final perspective of Hidayatul Athfal junior high schools’ students in implementing digital English learning which refers to Merdeka curriculum. Beforehand, the Ministry of Education issued one of the latest efforts to change the education system, which is popularly known as the Merdeka curriculum. Based on the Law of the Republic of Indonesia Number 20 of 2003 concerning the National Education System, curriculum is a set of plans and arrangements regarding objectives, content, and teaching materials, as well as methods used as guidelines for implementing up-to-date learning to achieve effective and optimal learning objectives. Apart from that, junior high school students in this research used learning media, it is barcode scanners as one of the learning media to make the digital system of the learning process at their meetings. The author uses a qualitative descriptive research method, which is conducted by direct observation and in-depth interviews with the parties involved, and the data collected is then analyzed descriptively by presenting the results of the research in the form of a research report. The conclusion of the research that the author draws that, it shows the implementation of the Merdeka curriculum is very helpful in assisting the junior high school students by adapting digital English learning process. It is proved that, 66.7% of students agreed with the implementation of the Merdeka Curriculum
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