1,720,958 research outputs found
GT-Predict
No full textWe utilized informatics and machine learning to build predictive software for enzyme functional annotation. The original application, GT-Predict, utilized the glycosyltransferase family 1 enzymes (GT1s) found in plants
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Synthesis of Glycopeptides in the Inhibition of Insulin Resistance Associated with FoxO1-Thr231-OGlcNAc
No full textviii, 20 p.Diabetes is one of the most widespread diseases in the United States, affecting more than 100 million adults1 and the amount of cases of diabetes is expected to continually rise over the coming years. Therefore, it is of vital importance to find a method of therapeutic treatment to insulin resistance. Further analysis of the framework and inner workings of the disease will help to determine the best method for the reversal of insulin resistance, particularly in cases of Type 2 diabetes mellitus (T2DM). The Forkhead Box O1 (FoxO1) regulatory protein is considered to play a key role in cellular sugar metabolism and insulin response. In particular, an amino acid site Threonine231 (Thr231) is hypothesized to be modified by a sugar group, O-linked N-acetylglucosamine (O-GlcNAc), in a manner that regulates metabolic signaling and insulin sensitivity. Using current knowledge of the insulin signaling pathway, it is proposed that a FoxoxO1 peptide mimic with an attached O-GlcNAc may lead to inhibition of the pathway if FoxO1-Thr231-O-GlcNAC is indeed the a stimulator of metabolic signaling. This project sought to synthesize sugar-peptide mimics of FoxO1-Thr231-O-GlcNAc in order to reverse the effects of T2DM. The sugar linked GlcNAc was synthesized over a succession of eight steps. The glycopeptide mimic was produced with the coupling of amino acids and an addition of a nuclear localization sequence as well as a fluorescent molecule, 5(6)-carboxyfluorescein (FAM), attached for visualization. Extensive optimization was done to the synthesis of the O-GlcNAc sugar as well as the glycopeptide mimic synthetic route to try and produce sufficient yield and accuracy in the product. The first step of the series of reactions was the primary focus of the optimization process, in order to improve the overall yield of the sugar-linked GlcNAc and purity of the final product. Optimization techniques included quadrupling the starting material and the addition of an argon line to create an inert atmosphere and using a sodium bicarbonate outflow line to neutralize the HCl gas. This eliminated a byproduct of the synthesis, HCl, improving the purity of the final product. However, the yield was still not sufficient to carry on to the final product. The production of peptide mimics of FoxO1-Thr231 was completed by coupling a variety of amino acids and monitored using the Kaiser test. These await sugar-coupling and testing in a suitable insulin resistance assay, work ongoing in the Fehl Laboratory. Due to complications with percent yield and optimization we were unable to determine the best method for effective reversal of insulin resistance. FurtherFuture analysis and manipulations of the insulin signaling pathways are will be key to determining the optimal technique for producing a treatment for both types of diabetes
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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