1,720,968 research outputs found
Possibile interazione tra i livelli plasmatici dell'omocisteina e le abitudini alimentari come fattori di rischio per lo sviluppo di patologie nell’uomo umana: Il ruolo nutraceutico dei supplementi vitaminici
No full textValutare il ruolo nutraceutico di integratori vitaminici nella patologia umana associata a disturbi metabolici dell'omocisteina. L'omocisteina è un aminoacido che si forma nel corpo a partire dalla metionina. Il metabolismo dell'omocisteina è regolato dalle vitamine B6, B12, acido folico e betaine. I fattori che determinano l'iperomocisteinemia sono: genetica, dieta, disturbi renali e altre condizioni mediche. Questo lavoro descrive 4 soggetti italiani con grave iperomocisteinemia.
Lo screening genetico è stato eseguito mediante Next Generation Sequencing (NGS). Questa tecnologia innovativa consente di poter sequenziare l’interol genoma. Questo approccio è particolarmente promettente per la diagnosi di malattie neuromuscolari pediatriche, endocrine, disturbi metabolici, ecc., caratterizzati da una forte eterogeneità clinica e genetica. Utilizzando NGS è possibile eseguire una diagnosi genetica senza limitare l’attenzione a un singolo gene candidato.
Combinando i dati clinici con il report derivante dalla sequenza dell’ esoma, individuiamo le mutazioni potenzialmente causative dei fenotipi osservati. Lo screening genetico ha consentito una corretta diagnosi e terapia con integratori vitaminici B6 (supplementazione orale), B12 (integratore parenterale), acido folico (supplemento orale) e betaina (supplemento orale), ciascuna somministrata individualmente. La terapia ha interamente corretto le anomalie metaboliche ei segni clinici (tabella 1).
La terapia con integrazione complessa di vitamina B è stata efficace in molte forme di iperomocisteinemia ed anche in queste forme di iperomocisteinaemia. Oggi la terapia con vitamina B12 consiste in integratori parenterali. Nel prossimo futuro, sarebbe opportuno avere una formulazione utile per la terapia orale sia per il cianocobalamina che per l'idrossicobalamina. Inoltre, sarebbe auspicabile avere un pool unico di complesso vitamina B (B6, B12, acido folico, betaino) sperimentato complessivamente con il cibo, per una terapia orale più facile per i pazienti.Objective of the work. To evaluate the role of vitamins supplementation in human pathology associated with metabolic disorders of homocysteine. Homocysteine is an amino acid that is formed in the body starting from the methionine. The metabolism of homocysteine is regulated by vitamins B6, B12, folic acid and betaine. The factors determining hyperhomocysteinemia are: genetic, diet, kidney disorders and other medical conditions. This report describes 4 italian subjects with severe hyperhomocysteinemia.
Methodological Detail. The genetic screening was carried out by Next Generation Sequencing (NGS). These innovative technologies allow a complete genome sequences. This approach is particularly promising for the diagnosis of pediatric neuromuscular diseases, endocrine, metabolic disorders, etc. that are characterized by a strong clinical and genetic heterogeneity. Using NGS it is possible to perform a genetic diagnosis without limiting to a single candidate gene.
Main Results of the study. Combining clinical data with the report resulting from exome sequencing we identify site specific mutations in each subject. The genetic screening allowed a correct diagnosis and therapy with vitamin supplements B6 (oral supplementation), B12 (parenteral supplementation), folic acid (oral supplementation) and betaine (oral supplementation) each one administered individually. The therapy fully corrected metabolic abnormalities and clinical signs (table 1).
Implications, meanings, conclusion that can be drawn from the data. The therapy with vitamin B complex supplementation has been effective in many forms of hyperhomocysteinemia as well as in these forms of severe hyperhomocysteinemia. Nowdays the therapy with vitamin B12 consists in parenteral supplementations. In the next future, it would be desiderable to have a formulation useful for oral therapy for both cianocobalamin and hydroxycobalamin. In addition, it would be desirable to have a unique pool of vitamin B complex (B6, B12, folic acid, betaine) hopefully complexed with food, for an oral therapy easier for patients
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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