1,721,184 research outputs found
Thymosin alpha 1 in the treatment of cancer: from basic research to clinical application
No full textMany studies have explored the effects of immunotherapy, alone or in combination with conventional therapies, on both experimental and human cancers. Evidence has been provided that combined treatments with thymosin alpha 1 (T alpha 1) and low doses of interferon (IFN) or interleukin (IL)-2 are highly effective in restoring several immune responses depressed by tumor growth and/or cytostatic drugs. In addition, when combined with specific chemotherapy, they are able to increase the anti-tumor effect of chemotherapy while markedly reducing the general toxicity of the treatment. The advantages of using this combined chemo-immunotherapeutic approach in experimental and human cancers are reviewed in this issue. (C) 2000 International Society for Immunopharmacology. Published by Elsevier Science Ltd. All rights reserved
Effetto sinergico dell'associazione tra amantadina, timosina alfa _1 e interferone in topi infettati con virus PR8.
No full textEffect of in vivo administration of prostaglandins and interferon on natural killer activity and on B-16 melanoma growth in mice
No full textComparison between natural reactivity (NR) against Candida albicans and natural killer (NK) activity against YAC-1 tumor cells
No full textCytotoxic activity against Candida albicans was measured in vitro in a 4-h 51Cr-release assay. The levels of reactivity correlated well with the number of polymorphonuclear cells in the effector population, being augmented by the enrichment of polymorphonuclear granulocutes. To exclude the possible role of contaminating natural killer cells, natural killer activity against tumour cells was compared with natural reactivity against Candida albicans in vitro. The findings indicate that there are many differences between these reactivities including organ and strain distribution, age dependency, adherence to nylon, and susceptibility to modulation by immuno-adjuvants and to treatment with anti-Thy 1.2 antiserum plus complement. These data further define in vitro polymorphonucleate-mediated cytotoxicity against Candida albicans on the basis of the above-mentioned criteria and clearly demonstrate that this in vitro reactivity could not be due to the presence of contaminating natural killer cells in the effector cell population
Stimulation of DNA synthesis by Interferon and Transforming Growth Factor b in EL2 rat fibroblasts
No full textSynergism between thymosin alpha one and epidermal Growth Factor in the stimulation of rat fibroblast cell proliferation: cellular and molecular aspects
No full textRegulation of cell proliferation by inducible-secreted proteins in growth factor-treated EL2 rat fibroblasts
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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