1,721,260 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Sintesi stereoselettiva di pirrolidin-2-oni sostituiti, precursori di dipeptidi con costrizioni conformazionali
No full textDisability associated with depressive symptoms in elderly primary care attenders
No full textLate-life depression is common, disabling and frequently comorbid with physical illness. This study examines a sample of 453 primary care attenders aged 65 years or over. In the screning phase the general health questionnaire-12 (GHQ-12) and the brief disability questionnaire (BDQ) were administered, and the primary care physicians (PCPs) rated the severity of physical illness and recorded the frequency of consultations. PCPs assessed GHQ high scores using the WHO ICD-10 checklist for depression to diagnose ICD-10 defined major episode of depression and subsyndromal depression (SSD), according to Olfson criteria. Mean BDQ score was 5.5 (± 4.9) in non-depressed subjects, 8.8 (± 5.9) in attenders with SSD, and 12.7 (± 5.9) in depressed attenders, with significant differences in each pairwise comparison. Both physical illness and depression independently result in an increased disability and PCP consultation, and when the two conditions are present, they have additive effect. Significant functional impairment is present not only in patients with full-fledged depression, but also in those with just symptoms of depression. Depression and physical illness can negatively ampact each other, resulting in persistent disability and poor prognosis
Sintesi stereoselettiva di 1,3-ossazolidin-2-oni attraverso reazioni di addizione coniugata
No full textSerine/threonine kinase 39 is a candidate gene for primary hypertension especially in women: Results from two cohort studies in Swedes
No full textBackground As recently pinpointed by a genome-wide association study the serine/threonine kinase 39 (STK39) is a candidate gene for hypertension. This kinase is strongly implicated in sodium reabsorption by the kidney through its modulating effect on furosemide-sensitive and thiazide-sensitive channels. The aim of our study was to test the effects of the STK39 rs35929607A > G polymorphism on blood pressure (BP) levels and the prevalence and incidence of hypertension in middle-aged Swedes participating in two urban-based surveys in Malmo (Sweden).Methods The rs35929607A > G polymorphism was genotyped in 5634 participants included in the cardiovascular cohort of the 'Malmo Diet and Cancer-cardiovascular arm' (MDC-CVA) study and successively in 17 894 participants of the 'Malmo Preventive Project' (MPP) both at baseline and at reinvestigation after a mean of 23 years. The effect of the same single nucleotide polymorphism on salt sensitivity was tested in 39 participants of the Salt Reduction to Avoid Hypertension study.Results Both before and after adjustment for covariates, the functional rs35929607A > G polymorphism was associated with higher SBP and DBP values in the MDC-CVA, but not in the MPP. In both surveys, the polymorphism was associated with hypertension prevalence; after adjustment using the autosomal-dominant model, the odds ratio for hypertension ranged between 1.077 (MPP at baseline) and 1.151 (MDC-CVA) with P-value less than 0.05. After stratification for sex, the results remained statistically significant in women, but not in men. Carriers of the G-allele displayed an increase in salt sensitivity.Conclusion Our results from two large cohort studies support previous evidence about the association of the STK39 rs35929607A > G variant with hypertension, especially in women. If further confirmed in successive studies, owing to its pivotal role in sodium reabsorption at the renal tubule level, STK39 might prove to be a suitable target for antihypertensive therapy. The greater effect of the STK39 rs35929607A > G polymorphism in women with respect to men deserves further investigation. J Hypertens 29:484-491 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins
The role of the clinical laboratory in the early diagnosis of preeclampsia.,Il ruolo del laboratorio clinico nella diagnosi precoce di preeclampsia
No full textHypertensive pregnancy disorders include a large spectrum of conditions, including pre-existing chronic hypertension, gestational hypertension, preeclampsia (PE) and eclampsia. In particular, PE is one of the most important causes of maternal morbidity and mortality and perinatal death, preterm birth, and delayed intrauterine growth. The studies support a pathogenetic model of insufficient placentation which results in a vicious circle clinically dominated by an increase in blood pressure and proteinuria in the first phase, and by the involvement of the central nervous system up to convulsions in the more advanced stages. A crucial aspect of patient management is therefore represented by the identification of biological markers measurable in maternal blood (circulating) useful in the diagnosis, prognostic stratification and monitoring. In particular, in recent years many resources have been used to identify a biophysical and biochemical screening test aimed at identifying women at greater risk of PE, but none of these tools when used alone has demonstrated a significant predictive value. Few biomarkers are currently used in clinical practice. The analysis of the literature suggests that angiogenic and anti-angiogenic molecules, in particular the fms-like-tyrosine-kinase receptor 1 and placental growth factor (sFlt-1/PlGF) ratio, can be considered the biomarkers with the best diagnostic performance in the second trimester of pregnancy. However, doubts remain about their use in clinical practice before the 20th gestational week. © 2021 Biomedia. All rights reserved
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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