8,373 research outputs found
Addressing new therapeutic strategies using models
No full textA disease model displays pathological processes observed in human or animal diseases. The models are fundamental tools in biomedical research, and they are invaluable for providing new insights into mechanisms underlying organ function, to establish the pathophysiology of a disease, and to test potential therapeutic approaches.
Models have been long used to study several diseases, including cardiovascular, oncologic, metabolic, infectious, and neurological diseases, among others. Animals or cells displaying pathological processes observed in human or animal diseases have been used as models. Moreover, mathematical models are also of great importance to disease modeling. Animal models offer the unique opportunity to investigate the function of genes and pathways and the in vivo effects of drugs, bridging the gap between basic science and the treatment of diseases. The selection of a suitable model system is a crucial step in research design. For disease modeling to be meaningful, a relevant cellular or genetic phenotype must be observed. Without the use of models, both research and clinical practice worldwide would be vastly different today.
This Special Issue aims to publish original research works or reviews with models of disease, highlighting their importance to search for new therapeutic strategies
Chemical carcinogens: an overview.
No full textFaustino-Rocha AI. 2023. Chemical carcinogens: an overview. 8th Edition of Global Conference on Pharmaceutics and Novel Drug Delivery Systems, 13 a 14 de mai
Addressing the importance of animal models for breast cancer Research
No full textFaustino-Rocha AI. 2023. Addressing the importance of animal models for breast cancer Research. 13th World Congress on Breast Cancer, 02 de maio (online
Are animal models important? An overview of animal models of cancer
No full textFaustino-Rocha AI. 2023. Are animal models important? An overview of animal models of cancer. International Conference on Veterinary Science, 28 a 29 de agosto
Animal models of skin cancer: the example of a chemically- induced rat model
No full textFaustino-Rocha AI. 2023. Animal models of skin cancer: the example of a chemically- induced rat model. 3rd Global Virtual Congress on Cancer research & Drug Development, 15 de maio
Prostate cancer
No full textThe prostate is the largest accessory gland of the male reproductive tract. Together with seminal vesicles and bulbourethral glands, the prostate is responsible for the production of an alkaline fluid that forms part of the seminal fluid. The prostate of men over 40 years of age is commonly affected by several pathologies, such as benign prostate hyperplasia and cancer.
Prostate cancer is one of the most frequent cancers among the male population worldwide. According to the World Health Organization (WHO), in the year 2020, prostate cancer affected approximately 1.41 million men and was responsible for the death of 375,304 of them. Prostate cancer development is associated with several risk factors including older age, black ethnicity, a family history of the disease, an increased body mass index, and obesity. The risk of prostate cancer development may be reduced through the consumption of a healthy diet full of fruits and vegetables, practice of physical exercise, and maintenance of a healthy weight.
Despite several approaches being available for prostate cancer treatment, the number of prostate cancer deaths is continuously increasing, which emphasizes the need to search for new methods for precocious diagnosis and more effective treatment. Animal models including rodents have greatly contributed to the study of biopathology and the prevention and treatment of prostate cancer.
This Special Issue entitled “Prostate Cancer II” aims to publish original research works and reviews concerning the diagnosis, treatment, and prognosis of prostate cancer, highlighting new advances in this field
Invenção em trânsito/transe: Glauber Rocha, Hélio Oiticica e Tropicália
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Literatura, Florianópolis, 2013.Terra em Transe, Tropicália. É já conhecida a relação criadora, propulsora entre o filme e a canção. Em retrospectivas tropicalistas, é oficial esta associação: o longa-metragem de Glauber Rocha ? a música que desencadeou o tropicalismo ? a instalação de Hélio Oiticica - a montagem do texto de Oswald de Andrade, O Rei da Vela, pelo teatro Oficina. Pretendemos aqui, além desse reconhecimento, compreender de que forma a obra cinematográfica de Glauber Rocha e a cena, o momento, o comportamento tropicalista, em alguns de seus aspectos, abrem pontos de aproximação e distanciamento, (des)encontram-se. Propomos, para isso, algumas leituras que partem primeiramente da análise de Terra em Transe, filme de 1967; seu impacto, fissura aberta em contexto, cenário cultural/estético/político, e dentro do próprio cinema do diretor; sua relação com os desdobramentos do conceito Tropicália, de Hélio Oiticica, vinculados às ideias políticas em torno da construção/arquitetura de Brasília, que desembocam na letra da composição de Caetano Veloso. Em um segundo momento do trabalho, é a análise mais detida de Deus e o Diabo na Terra do Sol (longa-metragem de Glauber, de 1964) que abre uma série de diálogos - em transe pela terra - com os processos de criação-invenção de Hélio Oiticica: os Penetráveis (marcadamente os de sua Tropicália); os Bólides (a proposição de obra aberta no Contra-Bólide N°1 Devolver a terra à Terra, e o "momento ético" no Bólide B33 Caixa 18 Homenagem a Cara de Cavalo); o Parangolé. É este que, através da dança, leva/conduz ao corpo, como elemento de desestruturação da linguagem cinematográfica, da música popular brasileira, e dos parâmetros estabelecidos do que seja arte. Nesses exercícios de aproximação e distanciamento, muitas vezes, o que entendemos por "teoria" sobressai dos escritos, críticas, pensamentos dos próprios criadores, colocados em (des)espelhamento no processo de apagamento das fronteiras entre vivência do cotidiano/criação artística, vida/obra.<br
Differential stability of 2'F-ANA*RNA and ANA*RNA hybrid duplexes: roles of structure, pseudohydrogen bonding, hydration, ion uptake and flexibility
No full text14 pags., 7 figs., 3 tabs.Hybrids of RNA with arabinonucleic acids 2′F-ANA and ANA have very similar structures but strikingly different thermal stabilities. We now present a thorough study combining NMR and other biophysical methods together with state-of-the-art theoretical calculations on a fully modified 10-mer hybrid duplex. Comparison between the solution structure of 2′F-ANA•RNA and ANA•RNA hybrids indicates that the increased binding affinity of 2′F-ANA is related to several subtle differences, most importantly a favorable pseudohydrogen bond (2′F-purine H8) which contrasts with unfavorable 2′-OH-nucleobase steric interactions in the case of ANA. While both 2′F-ANA and ANA strands maintained conformations in the southern/eastern sugar pucker range, the 2′F-ANA strand's structure was more compatible with the A-like structure of a hybrid duplex. No dramatic differences are found in terms of relative hydration for the two hybrids, but the ANA•RNA duplex showed lower uptake of counterions than its 2′F-ANA•RNA counterpart. Finally, while the two hybrid duplexes are of similar rigidities, 2′F-ANA single strands may be more suitably preorganized for duplex formation. Thus the dramatically increased stability of 2′F-ANA•RNA and ANA•RNA duplexes is caused by differencesin at least four areas, of which structure and pseudohydrogen bonding are the most important. © The Author(s) 2010. Published by Oxford University Press.Spanish Ministerio de Ciencia e Innovacion (grants
CTQ2007-68014-C02-02 to CG and BIO2009-10964 to
MO); Fundacion Marcelino Botin (grant to MO);
Canadian Institutes for Health Research (grant to
M.J.D.); Natural Sciences and Engineering Research
Council of Canada (postgraduate scholarship to
J.K.W.). Funding for open access charge: Canadian
Institutes for Health Research
Cineastas brasileiras em tempos de ditadura: cruzamentos, fugas, especificidades
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas, Programa de Pós-Graduação em História, Florianópolis, 2013.Esta tese trata dos filmes realizados por três diretoras brasileiras durante o período da ditadura militar (1964-1985), atravessados pela irrupção das reivindicações de emancipação e igualdade para as mulheres, principalmente nos anos 1970, e pela repressão do regime militar e seu órgão de censura, que buscavam moralizar a sociedade e manter as mulheres em seus papéis privados, tradicionalmente estabelecidos dentro da cultura e da sociedade brasileiras. Diante desse contexto, busco cartografar os caminhos por onde passam as carreiras de Helena Solberg, Tereza Trautman e Ana Carolina, esboçando e delineando contatos, circulações, citações e influências por meio de outros filmes e cineastas, do movimento de resistência à ditadura e dos #novos cinemas# que surgem a partir dos anos 1950, no período pós-segunda guerra mundial, entre eles o chamado #cinema de mulheres#, que trato aqui como um acontecimento. De maneira radical, essas diretoras adquiriram agenciamento, expandindo os horizontes da esquerda e questionando irreversivelmente o lugar das mulheres dentro das propostas de uma nova sociedade. Os efeitos de uma herança póscolonial perpassam a produção cinematográfica latino-americana, gerando no período recortado a necessidade de se buscar uma #identidade#, relacionada à resistência e a um sonhado novo cenário político, cultural e socioeconômico. A busca de novas estéticas estava intimamente ligada à política e isso esteve presente no trabalho dessas diretoras. A particularidade do cinema realizado por elas é a meta de compreensão desta tese, que busca seus cruzamentos, fugas e especificidades, que se expressam através da linguagem fílmica, mas que se fundem ao cenário de reivindicações dos movimentos sociais contemporâneos.Abstract : This thesis deals with films made by three Brazilian women directors during the military dictatorship (1964-1985), together with the eruption of claims of emancipation and equality for women, mainly in the 1970's, and by the repression of the military government and its censorship organism, which tried to moralize society and keep women in their private roles, traditionally established inside Brazilian culture and society. In this context, I intend to draw a map of the pathways by which passed through Helena Solberg, Tereza Trautman and Ana Carolina's careers, drafting contacts, circulations, citations and influences through other films and directors, the movement of resistance toward the dictatorship and the "new cinemas" that emerged from the 1950's, in the post-second world war period; between them "women's cinema", which I understand here as a happening. In a radical way, these directors acquired agency, expanded the left horizons and irreversibly questioned the place of women inside the purposes of a new society. The effects of a post-colonial heritage crossed Latin-American film production, generating at that moment a necessity of looking for an "identity" related to resistance and to the dream of a new political, cultural and social-economical scenario. The search of new aesthetics was closely related to politics and it was represented in these directors' films. This thesis goal is the particularity of the cinema made by them, looking for their crossroads, escapes and specificities, which are expressed through filmic language, but that are mixed to the contemporary social movements' vindications scenario
Hans Blumenberg: Historia In/conceptual, Antropología y Modernidad, por Faustino Oncina y Pedro García-Durán, eds.
No full textReview of Oncina Coves, Faustino y García-Durán, Pedro (eds.) 2015, Hans Blumenberg: Historia in/conceptual, antropología y modernidad, Valencia: Pre-Textos. ISBN 978-84-16453-06-1, 240 pp. Reseña de Oncina Coves, Faustino y García-Durán, Pedro (eds.) 2015, Hans Blumenberg: Historia in/conceptual, antropología y modernidad, Valencia: Pre-Textos. ISBN 978-84-16453-06-1, 240 páginas. Ressenya de Oncina Coves, Faustino y García-Durán, Pedro (eds.) 2015, Hans Blumenberg: Historia in/conceptual, antropología y modernidad, Valencia: Pre-Textos. ISBN 978-84-16453-06-1, 240 pàgs.
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