273 research outputs found
Risk factors for onset of chronic oro-facial pain - Results of the North Cheshire oro-facial pain prospective population study
No full textDue to the cross-sectional nature of previous studies, whether mechanical factors predict the onset of Chronic oro-facial pain remains unclear. Aims of the current study were to test the hypotheses that self-reported mechanical factors would predict onset of Chronic oro-facial pain and that any observed relationship would be independent of the confounding effects of psychosocial factors and reporting of other unexplained symptoms. About 1735 subjects who had completed a baseline questionnaire were assessed at 2 year follow-up for the presence of Chronic oro-facial pain, psychosocial factors (anxiety and depression, illness behaviour, life stressors and reporting of somatic symptoms), mechanical dysfunction (facial trauma, grinding, phantom bite and missing teeth) and reporting of other unexplained symptoms (chronic widespread pain, irritable bowel syndrome and chronic fatigue). About 1329 subjects returned completed questionnaires (adjusted response rate 87%). About 56 (5%) reported new episodes of Chronic oro-facial pain at follow-up. Univariate analyses showed that age, gender, reporting of other unexplained symptoms, psychosocial factors and two self-report mechanical factors predicted the onset of Chronic oro-facial pain. However multivariate analysis showed that mechanical factors did not independently predict onset. The strongest predictors were health anxiety (Relative Risk (RR) 2.8, 95% CI 1.3-6.2), chronic widespread pain (RR 4.0 95% C.I. 2.2-7.4) and age (RR 0.2, 95% CI 0.1-0.7). The findings from this prospective study support the hypothesis that psychosocial factors are markers for onset of Chronic oro-facial pain. The efficacy of early psychological management of Chronic oro-facial pain to address these factors should be a priority for future investigations. © 2010 International Association for the Study of Pain
The quality of prison primary care: cross-sectional cluster-level analyses of prison healthcare data in the North of England
Full text linkBackground: Prisoners have significant health needs, are relatively high users of healthcare and often die prematurely. Strong primary care systems are associated with better population health outcomes. We investigated the quality of primary care delivered to prisoners.Methods: We assessed achievement against 30 quality indicators spanning different domains of care in 13 prisons in the North of England. We conducted repeated cross-sectional analyses of routinely recorded data from electronic health records over 2017-20. Multi-level mixed effects logistic regression models explored associations between indicator achievement and prison and prisoner characteristics.Findings: We found marked variations in achievement between indicators and between prisons. Achievement ranged from 0·2% of people with epilepsy coded as seizure-free to 93·8% of people with diabetes having blood pressure checks over the preceding year. Achievement improved over three years for 11 indicators and worsened for six, including declining antipsychotic monitoring and rising opioid prescribing. Achievement varied between prisons, e.g. 1·93-fold for gabapentinoid prescribing without coded neuropathic pain (odds ratio [OR] range 0·67 to 1·29) and 169-fold for dried blood spot testing (OR range 0·05 to 8·45). Shorter lengths of stay were frequently associated with lower achievement. Ethnicity was associated with some indicators achievement, although the associations differed with indicators.Interpretation: We found substantial scope for improvement and marked variations in quality, which were largely unaltered after adjustment for prison and prisoner characteristics
The neuropeptide VGF produces antidepressant-like behavioral effects and enhances proliferation in the hippocampus
No full textBrain-derived neurotrophic factor (BDNF) is upregulated in the hippocampus by antidepressant treatments and BDNF produces antidepressant-like effects in behavioral models of depression. In our previous work, we identified genes induced by BDNF and defined their specific roles in hippocampal neuronal development and plasticity. To identify genes downstream of BDNF that may play roles in psychiatric disorders, we have examined a subset of BDNF-induced genes also regulated by serotonin (5-HT), which includes the neuropeptide VGF (non-acronymic). To explore the function of VGF in depression, we first investigated the expression of the neuropeptide in animal models of depression. VGF was downregulated in the hippocampus following both the learned helplessness (LH) and forced swim test (FST) paradigms. Conversely, VGF infusion in the hippocampus of mice subjected to FST reduced the time spent immobile for up to 6 days, thus demonstrating a novel role for VGF as an antidepressant-like agent. Recent evidence indicates that chronic treatment of rodents with antidepressants increases neurogenesis in the adult dentate gyrus and that neurogenesis is required for the behavioral effects of antidepressants. Our studies using 3H-thymidine and bromodeoxyuridine (BrdU) as markers of DNA synthesis indicate that chronic VGF treatment enhances proliferation of hippocampal progenitor cells both in vitro and in vivo with survival up to 21d. By double immunocytochemical analysis of hippocampal neurons, we demonstrate that VGF increases the number of dividing cells that express neuronal markers in vitro. Thus VGF may act downstream of BDNF and exert its effects as an antidepressant-like agent by enhancing neurogenesis in the hippocampus.Peer reviewe
Contribution of HLA-DRB1 shared epitope alleles and chronic inflammation to the increased incidence of cardiovascular disease in rheumatoid arthritis:Comment on the article by Farragher et al. - Reply
No full text
Geographic analysis of cannabis regulations in the Kootenay Region
Full text linkThis analysis was conducted for Tracey Harvey, GIS Instructor at Selkirk College in the School of Environment and Geomatics at the Castlegar campus and PhD student at the University of Guelph. It was also intended to serve as a resource for the average person to access information about municipal cannabis regulations across the Kootenay Region. The areas of study were limited to regulations of public consumption, retail licensing fees, and commercial production allowance
101 Careers in Nursing
No full textTracey Robert is a contributing author, Launching Your Career Search, p. 185-194.
Book description: Few careers offer the advantages that nursing offers: flexibility, room for growth, satisfaction from helping others. And there is a desperate need for nurses - demand will exceed supply for some time to come. This concise volume provides an overview of what\u27s possible in a nursing career. It profiles 101 different types of nursing careers, including a basic description, education requirements, skills needed, compensation, and related web sites and professional organizations. Personal stories from the practicing nurses highlight the content.https://digitalcommons.fairfield.edu/education-books/1028/thumbnail.jp
I love you to death : the voice of the woman artist : sex, violence, sentimentality
No full textIncludes abstract.Includes bibliographical references (p. 114-117).At a dinner party in Durban after the opening of Come, a 2007 exhibition of Michaelis MFA students, a woman asked me about my work. When I told her it was "the bullets", by way of description (One Hundred Bullets With Your Name On Them), she said something along the lines of "oh, that's so fascinating, I really had thought a man had made them"
Vitreoretinal interface abnormalities in middle-aged adults with visual impairment in the UK Biobank study: prevalence, impact on visual acuity and associations
Full text linkObjective: The aim of this study was to determine the prevalence of vitreoretinal interface abnormalities (VRIA), the degree of visual impairment and associations with VRIA among adults, aged 40–69 years, in the UK Biobank study. Methods and analysis: Colour fundus photographs and spectral domain optical coherence tomography images were graded for 25% of the 8359 UK Biobank participants with mild visual impairment or worse (LogMAR >0.3 or Snellen <6/12) in at least one eye. The prevalence and contribution of VRIA to visual impairment was determined and multinomial logistic regression models were used to investigate association with known risk factors and other predetermined socioeconomic, biometric, lifestyle and medical variables for cases and matched controls. Results: The minimum prevalence of any VRIA was 17.6% and 8.1% in the eyes with and without visual impairment, respectively. VRIA were identified as the primary cause of visual impairment in 3.6% of eyes. Although epiretinal membrane and vitreomacular traction were the most common VRIA, the degree of visual impairment was typically milder with these than with other VRIA. Visual impairment with a VRIA was positively associated with increasing age (relative risk ratio (RRR) 1.22 (95% CI 1.07 to 1.40)), female gender (RRR 1.28; 1.08 to 1.52) and Asian or Asian British ethnicity (RRR 1.60; 1.10 to 2.32).
Conclusions: VRIA are common in middle-aged adults in the UK Biobank study, especially in eyes with visual impairment. VRIA were considered to be the primary cause of visual impairment in 3.6% of all eyes with visual impairment, although there was variation in the degree of visual impairment for each type of VRIA
- …
