1,721,096 research outputs found
Esposizione occupazionale a radiazione solare in un campione di pazienti dermatologici.
No full textEsposizione occupazionale a radiazione solare in un campione di pazienti dermatologici
A Validated Photonumeric Scale for the Evaluation of Neck Skin Laxity
No full textBACKGROUND: Neck aging is usually evaluated together with the lower face. To date, a skin laxity scale for the neck as an independent anatomical district is lacking. OBJECTIVE: To create and validate a proposed photonumeric neck skin laxity (NSL) scale. MATERIALS AND METHODS: Frontal neck photographic images of 110 subjects were collected. Each standardized neck image was evaluated twice by 3 independent doctors, 1 week apart. A 4-point photonumeric NSL scale was developed (0 = absence of skin laxity and 4 = severe skin laxity) and validated in terms of intraobserver and interobserver correlation and internal consistency. RESULTS: The intraobserver reliability analysis of the 2 assessments performed by each observer revealed excellent correlation and consistency of the severity grading, independently of the time of evaluation (from 0.96 to 0.99, p < .01). Furthermore, the interobserver reliability analysis revealed an excellent agreement between the evaluators and an internal consistency independent of the evaluator (0.97, p < .01). CONCLUSION: The newly developed NSL scale is a reliable and reproducible scoring system for the aesthetic evaluation of skin laxity of the neck
Disguised basal cell carcinomas: how to track them down with reflectance confocal microscopy
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Congenital melanocytic nevi
No full textCongenital melanocytic nevi (CMN) are classified primarily by their projected adult size (PAS) with small nevi measuring <1.5 cm, medium between 1.5 and 19.9 cm (M1:1.5-10 cm, M2:>10-19.9 cm), large between 20 and 40 cm (L1:>20-30, L2:>3040 cm) and giant measuring >40 cm (G1:>4060 cm, G2:>60 cm). The vast majority of CMN are small.1-3 The PAS of CMN is correlated with the risk for developing melanoma. Small and medium-sized CMN are at low risk with less than 1% of lesions developing melanoma.3 In contrast, for large and giant CMN the risk for developing either cutaneous or extracutaneous melanoma is between 5% and 10%.4-7 It has been shown that small CMN often harbor BRAF mutations and larger CMN are mosaic RASopathies resulting from intrauterine postzygotic mutations in codon 61 of NRAS.8 It is interesting to note that these same somatic mutations are found in 15%-50% (NRAS and BRAF, respectively) of superficial spreading melanoma in adults, and in individuals with CMN these mutations may act as the first step in a multiple hit model toward malignant progression.8,9 Clinical presentation The clinical morphology of CMN is quite variable. Their size can range from tiny subclinical incipient nests of nevo-melanocytes in the dermis to nevi covering over 50% of the body surface area. They can also manifest irregular shapes, rugous to nodular surface, hypertrichosis, and variegation in color. For the smaller CMN, their clinical and dermoscopic morphology can be indistinguishable from acquired nevi. In general, the nevo-melanocytes in smaller CMN tend not to penetrate as deeply into the dermis as compared to the larger CMN-a characteristic that has important implications for selection of CMN amenable to reflectance confocal microscopy (RCM) imaging
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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