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Equilibrium and kinetic studies of hydroxy- and halogeno-mixed ligand complexes of Al(III), Ga(III) and Tl(III) aminopolycarboxylates
Get PDFAz Al(III)-, Ga(III)- és a Tl(III)- aminopolikarboxilát hidroxo- és halogeno- vegyesligandumú komplexeinek egyensúlyi és kinetikai vizsgálatait végeztük el, melynek eredményei az orvos diagnosztikában, elsősorban PET kontrasztanyagok fejlesztése során lehetnek hasznosak.
Az Al(NOTA)-F¯ rendszer vizsgálatai során szerzett információk alapján kutatócsoportunkban új NO2A származékok szintézisét tervezik, ezekben az egyik acetátcsoportot a fémionhoz nem koordinálódó csoportra cserélik, hogy az Al(III)-ion koordinációs szférájába be tudjon kerülni a F¯-ion.
Az Al(CDTA)¯- és az Al(CDTABBA)+-F¯ rendszerek vizsgálata során beigazolódott, hogy a nyíltláncú ligandumokkal sokkal gyorsabb a komplexképződés, mint a makrociklusos ligandumok esetében, emellett a stabilitás és az inertség is megmarad olyan mértékben, ami ígéretes a további vizsgálatokhoz.
A Ga(DATAm)-, Ga(DATA5m)¯-, Ga(PID(A))¯- és Ga(PID(B))¯-komplexek vizsgálatából kiderült, hogy bár a ligandumok fokszáma csökkent az AAZTA „alapligandumhoz” képest, de a ligandumok merevítésével növelhetjük a komplexek egyensúlyi állandóit és az inertségüket. Az eddig ismert, nem makrociklusos Ga(III)-komplexek közül a Ga(PID(B))¯-komplex a leginertebb, így ideális jelölt lehet PET farmakonnak.
A Tl(EDTA)¯-, Tl(CDTA)¯-, Tl(CDTABBA)+- és a Tl(cDO2A)+-I¯ rendszerek vizsgálata alapján a Tl(CDTABBA)I vegyesligandumú komplex tűnik a leginertebbnek. A CDTABBA ligandum további átalakításaival stabilabb és inertebb I¯ hordozóvá alakítható, ami ezáltal jó teragnosztikai ágens lehet.Equilibrium and kinetic studies of Al(III), Ga(III) and Tl(III) aminopolycarboxylate of hydroxy and halogeno mixed complexes have been performed. The results may be useful in medical diagnosies, especially in the development of PET contrast agents.
Based on the results of the Al(NOTA)-F¯ system, our group is planning to synthesize new NO2A derivatives, replacing one acetate group with a non-coordinating group to allow the F¯ ion to enter the Al(III) ion coordination sphere.
Examination of the Al(CDTA)¯ and Al(CDTABBA)+-F¯ systems has shown that open chain ligands have a much faster complexation than macrocyclic ligands, and the stability and inertness are maintained to an extent that is promising for further investigations.
Examination of Ga(DATAm)-, Ga(DATA5m)¯-, Ga(PID(A))¯ and Ga(PID(B))¯ complexes showed that although the denticity of ligands was reduced compared to the AAZTA "parent ligand", tailoring the ligands can increase the equilibrium constants of the complexes and their inertness. Among the non-macrocyclic Ga(III) complexes known to date, the Ga(PID(B))¯ complex is the most inert and thus can be an ideal candidate for a PET pharmacon.
According to the Tl(EDTA)¯-, Tl(CDTA)¯-, Tl(CDTABBA)+- and Tl(DO2A)+- I¯ systems, the Tl(CDTABBA)I mixed-ligand complex appears to be the most inert. Further modifications of the CDTABBA ligand can be converted to more stable and inert carrier, which can be a good teragnostic agent.d
Analysis of lichen secondary chemistry doubled the number of Cetrelia W.L. Culb. & C.F. Cub. species (Parmeliaceae, lichenised Ascomycota) in Hungary
Get PDFFIG. 9. — Distribution of Cetrelia monachorum (Zahlbr.) W.L. Culb. & C.F. Culb. in Hungary.Published as part of Farkas, Edit, Biró, Bernadett, Varga, Nóra, Sinigla, Mónika & Lőkös, László, 2021, Analysis of lichen secondary chemistry doubled the number of Cetrelia W.L. Culb. & C.F. Culb. species (Parmeliaceae, lichenised Ascomycota) in Hungary, pp. 1-16 in Cryptogamie, Mycologie 20 (1) on page 10, DOI: 10.5252/cryptogamie-mycologie2021v42a1, http://zenodo.org/record/781513
FIG. 6 in Analysis of lichen secondary chemistry doubled the number of Cetrelia W.L. Culb. & C.F. Culb. species (Parmeliaceae, lichenised Ascomycota) in Hungary
No full textFIG. 6. — Distribution of Cetrelia cetrarioides (Delise) W.L. Culb. & C.F. Culb.in Hungary before revision.Published as part of Farkas, Edit, Biró, Bernadett, Varga, Nóra, Sinigla, Mónika & Lőkös, László, 2021, Analysis of lichen secondary chemistry doubled the number of Cetrelia W.L. Culb. & C.F. Culb. species (Parmeliaceae, lichenised Ascomycota) in Hungary, pp. 1-16 in Cryptogamie, Mycologie 20 (1) on page 9, DOI: 10.5252/cryptogamie-mycologie2021v42a1, http://zenodo.org/record/781513
FIG. 7 in Analysis of lichen secondary chemistry doubled the number of Cetrelia W.L. Culb. & C.F. Culb. species (Parmeliaceae, lichenised Ascomycota) in Hungary
No full textFIG. 7. — Distribution of Cetrelia cetrarioides (Delise) W.L. Culb.& C.F.Culb. in Hungary after revision.Published as part of Farkas, Edit, Biró, Bernadett, Varga, Nóra, Sinigla, Mónika & Lőkös, László, 2021, Analysis of lichen secondary chemistry doubled the number of Cetrelia W.L. Culb. & C.F. Culb. species (Parmeliaceae, lichenised Ascomycota) in Hungary, pp. 1-16 in Cryptogamie, Mycologie 20 (1) on page 9, DOI: 10.5252/cryptogamie-mycologie2021v42a1, http://zenodo.org/record/781513
Kisméretű terménytároló,-szárító és tisztító beruházási folyamatának hatásvizsgálata a saját családi gazdaságban
No full textEgyetemi/MA/MS
Kukoricatermesztés technológiai sajátosságai egy Komárom-Esztergom megyei családi gazdaságban
No full textAlapszak/BA/BS
FIG. 7 in Analysis of lichen secondary metabolites and morphometrics in the Cladonia chlorophaea species group (Cladoniaceae, lichenized Ascomycota) in Hungary
No full textFIG. 7. — Width of podetium stalk (mm) in different species. Abbreviations: asa, C. asahinae (n = 22); chlo, C. chlorophaea (n = 55); cry, C. cryptochlorophaea (n = 53); gra, C. grayi (n = 17); mero, C. merochlorophaea (n = 70); novo, C. novochlorophaea (n = 10). The lines represent the minimum and maximum values, the box represents the 25% and 75% of the data, the thick line represents the median. Means with the same letter are not significantly different at 95% confidence.Published as part of Farkas, Edit, Lőkös, László & Veres, Katalin, 2023, Analysis of lichen secondary metabolites and morphometrics in the Cladonia chlorophaea species group (Cladoniaceae, lichenized Ascomycota) in Hungary, pp. 61-82 in Cryptogamie, Mycologie 20 (5) on page 69, DOI: 10.5252/cryptogamie-mycologie2023v44a5, http://zenodo.org/record/805598
FIG. 9 in Analysis of lichen secondary metabolites and morphometrics in the Cladonia chlorophaea species group (Cladoniaceae, lichenized Ascomycota) in Hungary
No full textFIG. 9. — Conditional inference tree presenting the five most important morphological variables separating species: CH, height of cup; CW, width of cup; PH, height of podetium; SW, width of podetium stalk. The order of the species at the end of the nodes is as follows: a, C. asahinae; c, C. chlorophaea; cr, C. cryptochlorophaea; g, C. grayi; m, C. merochlorophaea; n, C. novochlorophaea. Boxes represent the highest probability of a species occurrence on the tree node. A level of p <0.05 was considered for a significant difference.Published as part of Farkas, Edit, Lőkös, László & Veres, Katalin, 2023, Analysis of lichen secondary metabolites and morphometrics in the Cladonia chlorophaea species group (Cladoniaceae, lichenized Ascomycota) in Hungary, pp. 61-82 in Cryptogamie, Mycologie 20 (5) on page 71, DOI: 10.5252/cryptogamie-mycologie2023v44a5, http://zenodo.org/record/805598
FIG. 8 in Analysis of lichen secondary metabolites and morphometrics in the Cladonia chlorophaea species group (Cladoniaceae, lichenized Ascomycota) in Hungary
No full textFIG. 8. — The mean diameter of soredia (µm) measured on podetia (n = 10). Abbreviations: asa, C. asahinae (n = 22); chlo, C. chlorophaea (n = 55); cry, C. cryptochlorophaea (n = 53); gra, C. grayi (n = 17); mero, C. merochlorophaea (n = 70); novo, C. novochlorophaea (n = 10). The lines represent the minimum and maximum values, the box represents the 25% and 75% of the data, the thick line represents the median. Means with the same letter are not significantly different at 95% confidence.Published as part of Farkas, Edit, Lőkös, László & Veres, Katalin, 2023, Analysis of lichen secondary metabolites and morphometrics in the Cladonia chlorophaea species group (Cladoniaceae, lichenized Ascomycota) in Hungary, pp. 61-82 in Cryptogamie, Mycologie 20 (5) on page 70, DOI: 10.5252/cryptogamie-mycologie2023v44a5, http://zenodo.org/record/805598
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