187,483 research outputs found

    Divinità serpentiforme dalla tomba di Amenofi II

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    Scheda del catalogo della mostra "Egitto : la straordinaria scoperta del faraone Amenofi 2" tenutasi al museo MUDEC di Milano

    Genomewide linkage scan of schizophrenia in a large multicenter pedigree sample using single nucleotide polymorphisms

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    A genomewide linkage scan was carried out in eight clinical samples of informative schizophrenia families. After all quality control checks, the analysis of 707 European-ancestry families included 1615 affected and 1602 unaffected genotyped individuals, and the analysis of all 807 families included 1900 affected and 1839 unaffected individuals. Multipoint linkage analysis with correction for marker-marker linkage disequilibrium was carried out with 5861 single nucleotide polymorphisms (SNPs; Illumina version 4.0 linkage map). Suggestive evidence for linkage ( European families) was observed on chromosomes 8p21, 8q24.1, 9q34 and 12q24.1 in nonparametric and/or parametric analyses. In a logistic regression allele-sharing analysis of linkage allowing for intersite heterogeneity, genomewide significant evidence for linkage was observed on chromosome 10p12. Significant heterogeneity was also observed on chromosome 22q11.1. Evidence for linkage across family sets and analyses was most consistent on chromosome 8p21, with a one-LOD support interval that does not include the candidate gene NRG1, suggesting that one or more other susceptibility loci might exist in the region. In this era of genomewide association and deep resequencing studies, consensus linkage regions deserve continued attention, given that linkage signals can be produced by many types of genomic variation, including any combination of multiple common or rare SNPs or copy number variants in a region. Molecular Psychiatry (2009) 14, 786-795; doi:10.1038/mp.2009.11; published online 17 February 2009</p

    Modello di imbarcazione dalla tomba di Amenofi II

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    Scheda del catalogo della mostra "Egitto : la straordinaria scoperta del faraone Amenofi 2" tenutasi al museo MUDEC di Milano

    Clinopyroxenes From Vulcano (aeolian Islands, Italy) - Crystal-chemistry and Cooling History

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    Twenty-three clinopyroxene phenocrysts from different rock types with different emplacement mechanisms and cooling histories from Vulcano island (Aeolian Archipelago) were studied by microanalysis and single-crystal X-ray diffraction methods. Their structures were refined by the least-squares method to an average R value of 0.022. From the two techniques, reliable site-occupancy data, as well as accurate lattice and structural parameters, are obtained. The results show that, in spite of the quite large compositional variety of the host rocks, clinopyroxenes from Vulcano have a narrow compositional range. Not-withstanding this, they yield crystal-chemical patterns characterising the different volcanic units and reflecting the evolutionary trends. On the basis of cation partitioning on M1 and M2 sites, the pyroxene quenching temperature has been estimated and related to the cooling history of the rocks

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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