1,721,352 research outputs found
Influence of prenatal drug treatments on kidney function during fetal and neonatal life
No full textDrug-induced renal injury remains an important clinical problem in the newborn, particularly if preterm, and a prenatal exposure to drugs potentially nephrotoxic may influence renal function not only during pregnancy but also after birth. In this article, the pathophysiological role of some drugs taken during pregnancy has been discussed. In detail, the effects of antibacterials, NSAIDs, ACE-inhibitors and angiotensin II receptor antagonists on renal function have been analysed, reporting data available in the literature on the development of acute and long-term nephrotoxicity in the fetus and neonate: up to the present several cases of severe and sometimes irreversible renal insufficiency have been reported after prenatal exposure to these drugs
Lactoferrin is an important factor when breastfeeding and COVID-19 are considered.
No full textLactoferrin is an important factor when breastfeeding and COVID-19 are considere
The choice of amniotic fluid in metabolomics for the monitoring of fetus health - update
No full textIntroduction: In recent years, several studies have highlighted the promising role of metabolomics in the analysis of amniotic fluid (AF), to describe and characterize the interactions occurring between the mother and the fetus during prenatal development. Among the available biological fluids, AF represents an ideal substrate to provide dynamic information regarding fetal organogenesis and metabolism through pregnancy, since it originates from both maternal and fetal tissues and contains substances derived from placenta, fetal skin, lungs, gastric fluid, and fetal urine. Areas covered: In this paper, we provide an update reporting the most recent results on AF metabolomics in the assessment of feto-maternal health, regarding physiological pregnancies but even fields such as prematurity, bronchopulmonary dysplasia, fetal malformations, chromosomopathies, maternal diseases, placental inflammation or infections, maternal diet or exposure to exogenous substances, according to the literature found on MEDLINE since 2015. Expert opinion: Metabolomics shows a promising role in describing both physiology and disease; the goal would be the identification of biomarkers able to precociously and efficaciously detect pathological conditions, allowing the identification of complicated pregnancy and improving their management. However, this field is under development and its reliability still needs to be clarified, especially through more numerous and accurate studies
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