1,766 research outputs found
The Mechanism of Leader-Expressed Humility on a Physical Education Teacher’s Work Engagement—Exploring the Chain Mediation Effect of Teacher Efficacy and Felt Obligation
No full textMotivating a teacher's work engagement has been brought into focus within the educational field, yet there has been deficient detail on how leader-expressed humility may influence a physical education teacher's work engagement. Based on social information processing theory and trait activation theory, the study investigates the potential effects of leader-expressed humility on a physical education teacher's work engagement within the organizational situations of primary and secondary schools in China. Data were collected from 579 physical education teachers using self-reported questionnaires. Results fully supported the proposed chain mediation model that leader-expressed humility is a strong predictor for a physical education teacher's work engagement, and leader-expressed humility could indirectly affect a physical education teacher's work engagement through the independent mediating effect of teacher efficacy and felt obligation, as well as the chain mediating effect of the two. Implications for management and practice, limitations, and future research are discussed
Targeted Delivery of Nanovaccine to Dendritic Cells via DC-Binding Peptides Induces Potent Antiviral Immunity in vivo [Expression of Concern]
No full textLu Y, Liu ZH, Li YX, Xu HL, Fang WH, He F. Int J Nanomedicine. 2022;17:1593—1608.
We, the Publisher and Editor of International Journal of Nanomedicine, are issuing an expression of concern for the published article.
Following publication, concerns regarding the integrity of Figure 2A in the article were brought to the Journal’s attention. As part of the investigation, the authors were contacted for any information that would help confirm the validity of Figure 2A. Whilst the authors were cooperative, the concerns with Figure 2A still remain.
Therefore, we are unable to fully address the concerns regarding Figure 2A; however, the Editor confirms that the concerns raised about figure 2A do not affect the overall validity or integrity of the reported findings. We advise readers to interpret the information presented in Figure 2A with due caution.
The authors have been notified about this Expression of Concern. Should further information come to light, the journal will reassess any concern raised
Clustering documents using a Wikipedia-based concept representation
No full textThis paper shows how Wikipedia and the semantic knowledge it contains can be exploited for document clustering. We first create a concept-based document representation by mapping the terms and phrases within documents to their corresponding articles (or concepts) in Wikipedia. We also developed a similarity measure that evaluates the semantic relatedness between concept sets for two documents. We test the concept-based representation and the similarity measure on two standard text document datasets. Empirical results show that although further optimizations could be performed, our approach already improves upon related techniques
THE PROBLEM OF PORTRAYING A NEW TYPE OF NATIONAL CHARACTER IN ZH. AYMAUYTOV'S NOVEL “KARTKOZHA”
No full textThe paper is devoted to the depiction of a new type of national identity in Zh. Aymauytov's novel "Kartkozha". The methodological basis of the research conducted was given by the scientific works of Kazakh literary critics S. Kirabaev and R. Nurgali, in which they carried out versatile studies of the problems on the typology of Zh. Aymauytov's novels. In solving the tasks, the methods of historical and functional theory are used. It is argued that Kartkozha acts as a perfect embodiment of the national character that convincingly reflects through behaviour and thoughts the most significant trends in social development in the October Revolution period. We show how the author of the novel tries to combine the humanistic traditions of the education novel in world literature with the class criterion for evaluating the activities of an individual. The new national type offered by Zh. Aymauytov is inseparable from the socio-economic conditions, but the main sources (drivers) of its formation and development still go back to such notions as the ethno-historical memory, the constructive genotypic potential of morality that is actualized by a person in a national space
The etiology of esophageal cancer in high- and low- risk areas of Jiangsu province, China
No full text [Background]Esophageal cancer (EC) remains one of the most common and fatal malignancies worldwide. The geographic variation in EC occurrence is striking, and China is an area with one of the highest incidences of EC. A number of epidemiological studies have been conducted toward EC in the past decades, results suggested that tobacco smoking, alcohol drinking, unhealthy dietary factors and chronic injuries of the esophageal mucosa are important in the development of this disease. Genetic polymorphisms in enzymes involved in metabolism of carcinogens may also influence individual susceptibility. However, the effects of major lifestyle and hereditary risk factors on the development of EC remain poorly understood in China. Moreover, little attention has been paid to the etiological heterogeneity between similar areas with great risk gradient. [Methods]From 2003 to 2007, a large population-based case-control study of EC has been conducted in a selected high-risk area and a selected low-risk area of Jiangsu Province, one of the highest cancer incidence areas in China. In total, 1,520 cases and 3,879 controls were recruited. In this thesis, we evaluated the role of major lifestyle factors such as tobacco smoking, alcohol drinking and dietary factors, as well as inherited determinants including family history of cancer and genetic polymorphisms of alcohol-metabolizing related genes on the risk of EC. In addition, we investigated how much of the risk gradient between two areas could be explained by variation in the distributions of major risk factors. [Results] Tobacco smoking and alcohol drinking moderately increased the risk of EC, while the positive associations were only found among men but not among women. Dietary factors were observed to play important roles in the development of EC. Specific dietary habits i.e., fast eating speed, and hot eating and/or drinking substantially elevated EC risk and could explain more than 20% of EC cases each. High intake of salty foods and fried foods, low consumption of raw garlic were also observed to increase the risk of EC. In addition to environmental and lifestyle factors, we confirmed that a positive family history can significantly increase EC risk, and found the inheritance may modify the effect of some unhealthy lifestyles. Moreover, we further explored the relationship between EC and single nucleotide polymorphismsof ADH1B, ADH1C and ALDH2 genes. Results showed that the slow metabolizing ADH1B G allele, ADH1C G allele and ALDH2 A allele significantly increased EC risk among moderate-to-heavy alcohol drinkers, and a significant interaction was observed between ALDH2 gene and alcohol consumption. Lastly, we found that more than 60% of EC cases could be attributable to major lifestyle risk factors in the study population; furthermore, dissimilar distribution of several lifestyle factors, together with variations of hereditary factors may be largely responsible for the incidence difference between two study areas. [Conclusion]The findings in this thesis confirm that unhealthy lifestyles including smoking, alcohol drinking and some dietary factors are the predominant risk factors of EC in China, and a large proportion of incidence difference between regions at varying risk could be attributed to the different prevalence of lifestyle factors. As most of the identified risk factors are modifiable, these could be translated into risk reduction prevention programs in China, and a substantial proportion of new EC cases are expected to be prevented by eliminating or avoiding these risk factors in the population. </p
MEAN FIELD SOLUTION OF SLAVE BOSON THEORY TO A MIXED-VALENCE TM IMPURITY SYSTEM
No full textPhysics, MultidisciplinarySCI(E)0ARTICLE123-311
Search for invisible decays of Higgs bosons in the vector boson fusion and associated ZH production modes
No full textA search for invisible decays of Higgs bosons is performed using the vector boson fusion and associated ZH production modes. In the ZH mode, the Z boson is required to decay to a pair of charged leptons or a bb quark pair. The searches use the 8┬á TeV pp collision dataset collected by the CMS detector at the LHC, corresponding to an integrated luminosity of up to 19.7┬á fb-1. Certain channels include data from 7┬á TeV collisions corresponding to an integrated luminosity of 4.9┬á fb-1. The searches are sensitive to non-standard-model invisible decays of the recently observed Higgs boson, as well as additional Higgs bosons with similar production modes and large invisible branching fractions. In all channels, the observed data are consistent with the expected standard model backgrounds. Limits are set on the production cross section times invisible branching fraction, as a function of the Higgs boson mass, for the vector boson fusion and ZH production modes. By combining all channels, and assuming standard model Higgs boson cross sections and acceptances, the observed (expected) upper limit on the invisible branching fraction at mH = 125 ┬á GeV is found to be 0.58┬á(0.44) at 95┬á% confidence level. We interpret this limit in terms of a Higgs-portal model of dark matter interactions. © 2014, The Author(s)
Poetic Biography of G.-Zh. Tuguldurov (1817-1872), the Vth Abbot of Aginsky Datsan Dechen Lhundupling
No full textIntroduction. TThe article is devoted to the study of the poetic namthar — the biography of the Vth abbot of the Aginsky datsan Dechen Lhundupling Galsan-Zhimba Tuguldurov. The purpose of the study is analysis and introduction of this biography into scientific circulation. A previously unexplored manuscript of a Tibetan-language namthar from the collections of the Aginsky datsan was the object of the research. A copy of this manuscript “Seeds of the biography of the abbot of the monastery Dechen Lhundupling Choje Kelsang Jinpa Pelsangpo” (Tib. bde chen lhun grub gling gi khri pa chos rje skal bzang spyin pa dpal bzang po'i rnam thar gyi sa bon bzhugs) by unknown author was kindly given to us by the fund custodian D.V. Vakunin. The chronological scope of the source covers the period from 1817 to 1872. The relevance of this work is caused by the need of introducing this source into scientific circulation due to the fact that despite the significance of the personality of G.-Zh. Tuguldurov in the history of Buryat Buddhism, information about him and his works have not yet been fully researched. As a result of the study, new historical facts of the biography of G.-Zh. Tuguldurov were revealed; the names of his Mongolian teachers were established; a description of his contribution to the development of Buddhism in the Aginsky and Tsugolsky monasteries was given; the circumstances of G.-Zh Tuguldurov’s passing from life were described; founded was an unidentified earlier as his work a Sanskrit-Tibetan dictionary “Sanskrit-Tibetan dictionary with explanations compiled by Choje Tri-Rinpoche”
The birth of the Reader doesn't mean death of the Author
No full textThe reviewed book of the modern English theorist of a modernism Max Saunders, Selfimpression: Life-Writing, Autobiografiction and the Forms of Modern Literature, offers original research of a phenomenon of the life-writing. Saunders analyzes, in parallel with critical work concerning the autobiography in fiction, works of the first row of the European literary modernism and postmodernism with 1870 for 1930. He offers new treatment of dialogue of the author - hero - reader, caused by the selfimpression-autobiography of the reader as reaction to the selfimpression-biography of the author put in the text. For this purpose the scientist assorts as, in what ways writers unite life-writing with a fiction. As a result Saunders's research forces to reconsider the settled concepts about the autogenic hero and a parity of the author - hero - reader, especially in Soviet-Russian scientific tradition
Proteomic Analysis of the Effects of Shenzhu Tiaopi Granules on Model Rats with Type 2 Diabetes Mellitus
No full textJin-Dong Zhao,1– 3 Zhao-Hui Fang1– 3 1Department of Endocrinology Two, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui Province, 230031, People’s Republic of China; 2Center for Xin’an Medicine and Modernization of Traditional Chinese Medicine of IHM, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui Province, 230012, People’s Republic of China; 3Diabetes Institute, Anhui Academy Chinese Medicine, Hefei, 230012, People’s Republic of ChinaCorrespondence: Zhao-Hui Fang, Department of Endocrinology Two, the First Affiliated Hospital of Anhui University of Chinese Medicine, 117 Meishan Road, Hefei, Anhui Province, 230031, People’s Republic of China, Email [email protected]: Shenzhu Tiaopi granule (STG) has antidiabetic functions. Data-independent acquisition proteomic technology is an integral part of systems biology. Herein, proteomics was used to analyse the effects of STG on type 2 diabetes mellitus (T2DM) and the mechanism by which STG normalizes glucose metabolism.Methods: Goto-Kakizaki (GK) T2DM model (Mod) rats, aged 15– 16 weeks and with a fasting blood glucose (FBG) level of ≥ 11.1 mmol/L, were treated with metformin or STG for 12 weeks. Wistar rats aged 15– 16 weeks were included in the control (Con) group. Body weight, FBG, total cholesterol (TC), total triglyceride (TG) levels and low-density lipoprotein (LDL-C) levels were measured, and pathological observation, Western blot analysis and data-independent acquisition proteomics of the liver were performed.Results: Significant differences in FBG, TC, TG, LDL-C (p < 0.01) and pathological liver morphology were observed between the Mod group and Con group, whereas both metformin and STG normalized the glucose and lipid metabolism indicators (p < 0.05 or p < 0.01). In total, 5856 proteins were identified via proteomic analysis, 97 of which were significantly differentially expressed in the liver and affected fatty acid metabolism, unsaturated fatty acid biosynthesis, the peroxisome proliferator-activated receptor (PPAR) signalling pathway, pyruvate metabolism, and terpenoid backbone biosynthesis. Screening identified 10 target proteins, including perilipin‐2 (Plin2), pyruvate dehydrogenase kinase 4, farnesyl diphosphate synthase (Fdps) and farnesyl-diphosphate farnesyltransferase 1. Among these proteins, the key proteins were Plin2 and Fdps, which were found to be associated with the PPAR signalling pathway and terpenoid backbone biosynthesis via relationship networks. Plin2 and Fdps are closely related to hyperglycaemia. STG can downregulate Plin2 and upregulate Fdps (p < 0.01).Conclusion: STG ameliorated hyperglycaemia by significantly altering the expression of different proteins, especially Fdps and Plin2, in the livers of GK rats. These findings may reveal the potential of traditional Chinese medicine for treating T2DM.Keywords: type 2 diabetes mellitus, improving hyperglycaemia, proteomics, Fdps, Plin2, Shenzhu Tiaopi granul
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