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    Tu es Petrus - // Hymne du Pape. // composé pour la Célébration du // 18 centième aniversaire de // St Pierre, en 1867 à Rome // par F. Liszt. // Edition pour orgue (manuscrit autographe)

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    Titre uniforme : Liszt, Franz (1811-1886). Compositeur. [Der Papst-Hymnus. LW E19b (2e version)]Dédicace à la p. de t. : "à mon cher voisin // de San Sebastiano // Don Zeffirino Falcione [Falcioni ?]. // F. Liszt". Signé à la fin "F. Liszt" (f. [4] r°). - Il s'agit d'une des nombreuses versions faisant partie d'une constellation d'oeuvres en lien avec la Papauté composées par Liszt entre 1863 et 1867 autour d'un même matériau musical et qui portent divers titres, dont "Hymne du Pape". Une version chorale est insérée dans l'oratorio "Christus". La présente version pour orgue est inédite et légèrement différente de la version éditée par Repos (Paris, 1867 ; voir Ms. 185) ; elle été réalisée en 1867 pour Don Zeffirino Falcioni lors du séjour de Liszt au monastère du Monte Mario à Rome. - Manuscrit à l'encre noire, avec quelques ratures et grattages (f. [3 r°-4 r°]). - Même papier que Ms. 185Orgue, Musique d' -- +* 1800......- 1899......+:19e siècle

    Protein dynamics in minimyoglobin: is the central core of myoglobin the conformational domain?

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    The kinetics of CO binding to the horse myoglobin fragment Mb-(32-139), the so-called "mini-Mb," were investigated by laser flash photolysis in 0.1 M phosphate buffer and in buffer with 75\% (vol/vol) glycerol. The reaction displays complex time courses that can be approximated satisfactorily only with a sum of five exponentials. The features of the kinetic components and a comparison of the deoxy-minus-carbonyl difference spectra of mini-Mb and horse Mb obtained under equilibrium conditions, with the kinetic difference spectra resulting from the global analysis of the traces recorded between 400 and 450 nm, show that CO binding to mini-Mb is accompanied by large structural changes. In view of the fact that mini-Mb is an approximation of the Mb-(31-105) fragment encoded by the central exon of the Mb gene, this finding is particularly relevant. On the basis of our data and previous reports [De Sanctis, G., Falcioni, G., Giardina, B., Ascoli, F. & Brunori, M. (1988) J. Mol. Biol. 200, 725-733; De Sanctis, G., Falcioni, G., Grelloni, F., Desideri, A., Polizo, F., Giardina, B., Ascoli, F. & Brunori, M. (1992) J. Mol. Biol. 222, 637-643], we propose that the protein fragment encoded by the central exon of the Mb gene is the domain responsible for ligand-linked conformational transitions, while the two terminal fragments dampen the amplitude of the structural changes that accompany ligand binding, thus rendering the protein stable and kinetically more efficient in its physiological function

    Intracranial facial nerve grafting after removal of vestibular schwannoma

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    Am J Otolaryngol. 2009 Mar-Apr;30(2):83-8. Epub 2008 Jul 22. Intracranial facial nerve grafting after removal of vestibular schwannoma. Bacciu A, Falcioni M, Pasanisi E, Di Lella F, Lauda L, Flanagan S, Sanna M. SourceDepartment of Otolaryngology, University of Parma, Parma, Italy. [email protected] Abstract OBJECTIVE: The objectives of this study were to evaluate outcomes from facial nerve (FN) cable grafting in patients who experienced FN transection during vestibular schwannoma removal and to compare the FN outcomes of patients who underwent FN grafting by using fibrin glue with those of patients who underwent FN grafting by using microsuture. MATERIAL AND METHODS: We retrospectively evaluated a series of 33 patients in whom FN grafting was achieved either by using microsuture (8 cases) or fibrin glue (25 cases). Immediate repair of the FN was performed in all cases at the time of initial resection. The patients FN function was assessed preoperatively, in the immediate postoperative period, and at 3, 6, 9, and 12 months or more postoperatively using the House-Brackmann grading system. All patients had at least 1-year follow-up. RESULTS: At 12 months, a House-Brackmann grade III was achieved in 75% of those who underwent cable nerve graft interposition by using microsuture and in 76% of those who underwent cable nerve graft interposition by using fibrin glue. Analysis of final FN function outcomes demonstrated no statistically significant difference in FN outcomes between the 2 groups (P = .891, Mann-Whitney U test; P = .1, Fisher exact test). CONCLUSIONS: The functional results after FN cable grafting by using fibrin glue exclusively were equivalent to those obtained with microsuture. However, the technique of FN repair by means of fibrin glue is technically simple, less time-consuming, and imparts less trauma on the nerve than does the traditional suture method
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