86,650 research outputs found
Le cooperative di dati sanitari tra codice civile e Data governance act
No full text’opera raccoglie i contributi del Progetto di Terza Missione dell’Università di Bologna sulle Cooperative di dati, disciplinate per la prima volta con il Data Governance Act (Reg. UE 2022/868) ed ivi inquadrate quali fornitori di servizi di intermediazione di dati. Il volume, in una prospettiva interdisciplinare, analizza tale nuovo framework giuridico, per giungere – attraverso l’interazione tra mondo accademico ed imprenditoriale – alla realizzazione di un modello fattibile, sostenibile ed efficiente di «cooperativa di dati», all’interno della cornice teorica del neomutualismo digitale. Il volume include anche un modello di statuto di cooperativa di dati. This publication collects the contributions of the Third Mission Project of the University of Bologna on Data Cooperatives, which are, for the first time, regulated by the Data Governance Act (EU Reg. 2022/868) and framed therein as data intermediation services providers. From an interdisciplinary perspective, this volume analyses the aforementioned new legal regime, in order to achieve – through the interaction between academia and business – the development of a feasible, sustainable and efficient model of a ‘data cooperative’, within the theoretical framework of digital neo-mutualism. The volume also includes a model statute of a data cooperative
Corrigendum: FLASH Radiotherapy With Electrons: Issues Related to the Production, Monitoring, and Dosimetric Characterization of the Beam
No full textIn the original article, the following authors were missing: Luigi Faillace, Lucia Giuliano, Mauro Migliorati, Luigi Palumbo. The corrected Author Contributions statement appears below. Affiliation 3, ‘Sapienza University of Rome, Rome, Italy’, is also added for authors LF, LG, MM, and LP. The authors apologize for these errors and state that this does not change the scientific conclusions of the article in any way. The original article has been updated
Doppia Diagnosi
No full textA person with dual diagnosis is a subject that simultaneously presents psychiatric disorders and drug addiction. Below are presents seven cases of individuals with these conditions of the area of Alcamo and treatment conditions. Objectives. trace in general the concept of dual diagnosis and analyse cases at SER.T of Alcamo with the respective treatmen
A NEW VITAMIN K EPOXIDE REDUCTASE COMPLEX SUBUNIT-1 (VKORC1) MUTATION IN A PATIENT WITH DECREASED STABILITY OF CYP2C9 ENZYME.
No full textdescrizione di una nuova mutazione genica della vitamina K ossidoreduttasi correlata ad una resistenza alla terapia con anticoagulante orale utilizzata nella profilassi trombotic
EQUINE GASTRIC ULCERATION SYNDROME (EGUS) IN DONKEYS: GASTROSCOPIC FINDINGS AND PREVALENCE
No full textThe aim was to present the findings of gastroscopy in a population of adult donkeys. Thirty-nine donkeys (16 jennies, 23 jacks), aged 1-18 years (5.7±5.0, median 3 years) underwent gastroscopy to evaluate the presence of lesions. Inclusion criteria: not athletes and non-working donkeys, breeding animals, no administration of NSAIDs or corticosteroids for at least 20 days immediately prior gastroscopy. Gastroscopy was performed after 15h of fasting, under sedation using a portable processor Gastropack and a 300cm long scope. ESGD lesions were scored 0/4, EGGS was described as presence or absence, anatomical location, distribution, and appearance of lesions. Chi square test and Fisher’s exact test were applied to verify differences in the prevalence of ESGD in relation to sex and age (≤4 years and >4 years).
Gastric lesions were not present in 19/39 (49%) donkeys, while 20/39 (51%) donkeys showed EGUS; 19/20 (95%) donkeys were affected by ESGD, while 1/20 (5%) donkey showed both ESGD and EGGD. ESGD was 0 in 19/39 (48.7%), 1 in 5/39 (12.8%), 2 in 10/39 (25.6%), 3 in 4/39 (10.2%) and 4 in 1/39 (2.7%) donkeys, respectively. EGGD lesion was a mild depression in the ventral glandular fundus. Statistical analysis showed no differences in relation to sex or age.
To the authors’ knowledge this is the first report on alive donkeys. Our prevalence was higher then in dead/euthanized donkeys, but similar to sports and pleasure horses. No statistical differences in the prevalence of ESGD in relation with sex or age were detected, in line to literature
Equine gastric ulceration Syndrome (EGUS) in Donkeys: gastroscopic findings and prevalence.
No full textThe aim was to present the findings of gastroscopy in a population of adult donkeys. Thirty-nine donkeys (16 jennies, 23 jacks), aged 1-18 years (5.7±5.0, median 3 years) underwent gastroscopy to evaluate the presence of lesions. Inclusion criteria: not athletes and non-working donkeys, breeding animals, no administration of NSAIDs or corticosteroids for at least 20 days immediately prior gastroscopy. Gastroscopy was performed after 15h of fasting, under sedation using a portable processor Gastropack and a 300cm long scope. ESGD lesions were scored 0/4, EGGS was described as presence or absence, anatomical location, distribution, and appearance of lesions. Chi square test and Fisher’s exact test were applied to verify differences in the prevalence of ESGD in relation to sex and age (≤4 years and >4 years).
Gastric lesions were not present in 19/39 donkeys, while 20/39 donkeys showed EGUS; 19/20 donkeys were affected by ESGD, while 1/2 (5%) donkey showed both ESGD and EGGD. ESGD was 0 in 19/39 (48.7%), 1 in 5/39 (12.8%), 2 in 10/39 (25.6%), 3 in 4/39 (10.2%) and 4 in 1/39 (2.7%) donkeys, respectively. EGGD lesion was mild depressed in the ventral glandular fundus. Statistical analysis showed no differences in relation to sex or age.
To the authors’ knowledge this is the first report on alive donkeys. Our prevalence was higher then in dead/euthanized donkeys, but similar to sports and pleasure horses. No statistical differences in the prevalence of ESGD in relation with sex or age were detected, in line to literature
Characterization of trotter horses urine metabolome by means of proton nuclear magnetic resonance spectroscopy
No full textBackground Metabolomics has been recognized as a powerful approach for disease screening. In order to highlight potential health issues in subjects, a key factor is the possibility to compare quantitatively the metabolome of their biofluids with reference values from healthy individuals. Such efforts towards the systematic characterization of the metabolome of biofluids in perfect health conditions, far from concluded for humans, have barely begun on horses. Objectives The present work attempts, for the first time, to give reference quantitative values for the molecules mostly represented in the urine metabolome of horses at rest and under light training, as observable by 1H-NMR. Methods The metabolome of ten trotter horses, four male and six female, ranging from 3 to 8 years of age, has been observed by 1H-NMR spectroscopy before and after three training sessions. Results We could characterize and quantify 54 molecules in trotter horse urine, originated from diet, protein digestion, energy generation or gut-microbial co-metabolism. Conclusion We were able to describe how gender, age and exercise affected their concentration, by means of a two steps protocol based on univariate and robust principal component analysis
Pharmacokinetic Evaluations of Sulpiride After Intravenous, Intramuscular, and Oral Single-Dose Administration in Jennies (Equus asinus)
No full textSulpiride is an antipsychotic human drug. It is commonly used to encourage ovulation in
noncycling mares and to stimulate lactation in adoptive mares. No pharmacokinetic data
are available for donkeys. The aim of this study was to assess the pharmacokinetics profile
of sulpiride after intravenous (IV), intramuscular (IM), and oral (PO) administrations in
healthy jennies. Animals (n 1⁄4 6) were treated with sulpiride, 1 mg/kg by IV, IM, and PO
routes according to a randomized cross-over design (3 3 Latin square). Blood samples
(5 mL) were collected at predetermined times and analyzed using a validated high performance
liquid chromatography with fluorescence detection method. IV and IM administrations
gave similar curves, but they were not bioequivalent. The IM average
bioavailability was 73.5%. After PO administration, the drug plasma concentrations were
low and consequently both area under the curve and bioavailability (9.4%) were low. This
finding could be because of the physicochemical features of the drug. Indeed, considering
that sulpiride is a weak base, existing in the ionized form at gastric and physiological pH, it
is unsurprising that it is poorly absorbable, especially in equine species whose gastric pH is
particularly acidic. In conclusion, injective routes are definitely preferable to PO dosing
because of the very low F% via this route
Il principio di privacy by design e privacy by default
No full textIl volume mira a tracciare una riflessione sui Principi in materia di protezione dei dati personali, con attenzione anche ai nuovi European Digital Rights and Principles (destinati a riscrivere i valori della Digital Society and Economy del nuovo millennio), alla libera circolazione dei dati e alla data governance. Di ogni principio viene analizzato l’inquadramento normativo, la portata applicativa nell’interpretazione dottrinale e in quella istituzionale, nonché l’applicazione concreta nella casistica
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