1,721,081 research outputs found
New Phenomenological Horizons
Full text linkPreferring the word ‘horizon’ is focusing readers’ attention on the vision of phenomenology as a method at
the same time recursive and productive. The issue collects the results of the efforts of a new generation of
researchers, gathered for some years around two research experiences located in different times and spaces,
but united by a healthy and rigorous experimental approach, i.e. the collective translation of the first part of
Husserliana XLII (Grenzprobleme der Phänomenologie. Analysen des Unbewusstseins und der Instinkte.
Metaphysik. Späte Ethik (Texte aus dem Nachlass 1908-1937) and the establishment of the International
Research Summer School on Genetic Phenomäenology held at the Institute for Philosophy and Sociology
of the Polish Academy of Sciences in Warsaw as part of the International Network Genetic Phenomenology
and the Human Science
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
The Arabidopsis thaliana SIRT2 sirtuin is involved in DNA damage response
No full textSirtuins, NAD-dependent deacetylases, are present in all organisms playing a central role in
many metabolic pathways such as cell survival, energy metabolism, lifespan and ageing.
Among the seven human sirtuins, SIRT4 and SIRT6 share conserved domains with the two
sirtuins present in the flowering plant Arabidopsis thaliana, named SRT1 and SRT2. In particular
SRT1 has sequence homology to nuclear SIRT6 while SRT2 to mithochondrial SIRT4.
Several roles for SIRT4 are known but recently its engagement in DNA Damage Response
(DDR) has been proposed.
Among metabolic pathways that limit proliferation under damage, the repression of glutamine
metabolism has been demonstrated. In human cells, the transcriptional activation of Sirt4 gene, in
response to DNA-damaging agents, inhibits both glutamine entry into the cells and glutamate
dehydrogenase (GDH) activity, decreasing the production of tricarboxylic acid cycle intermediates
and reducing energy for proliferation (Jeong et al, 2013).
Few and contrasting data are until now available on plant SRT2. A lysine deacetylase activity
and an involvement in energy metabolism and pathogen defense have been reported for this sirtuin.
In a project to search for equivalent functions of conserved genes deriving from
phylogenetically distant organisms, here we present an analysis to verify if SRT2 displays in plant
the same role observed for SIRT4 in human cells.
We have evidenced by informatic programmes that the two sirtuins SIRT4 and SRT2 share
not only aminoacid sequence but also tridimensional structure.
Then we have developed an in vivo assay in Arabidopsis to monitor SRT2 expression, cell
proliferation and viability, and to evaluate glutamine metabolism.
We demonstrate, in Arabidopsis seedlings, after a DNA damage treatment with camptothecin
(CPT), a topoisomerase 1 inhibitor, a time and dose-dependent transcriptional activation of SRT2
gene. In parallel, we observe an inhibited cell proliferation and a decreased GDH activity.
These data suggest that SRT2 is not only activated in the DDR, but it is also implicated in the
glutamine regulation.
The same parameters will be evaluated in the selected SRT2 mutant plants obtained by TDNA
insertional technique
Palmoplantar Psoriasis: A Clinico-Pathologic Study on a Series of 21 Cases with Emphasis on Differential Diagnosis
No full textDispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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