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Utilization and regulation of carbon sources and their metabolism in the halophilic archaeon Halogeometricum borinquense
Get PDFGene regulatory systems contribute to an organism’s fitness by providing a way to dynamically tune cellular responses in response to fluctuating environmental conditions. In this work, we compare the regulatory tuning of genes involved in the catabolism of glucose, maltose, and sucrose in the metabolically versatile halophilic archaeon Halogeometricum borinquense through functional transcriptomic profiling, targeted qRT-PCR, and sugar utilization assays. This work provides the first transcriptomic study for this organism, preliminarily characterizes the unique and shared responses of H. borinquense to single- and multiple-sugar growth conditions, identifies key metabolic regulatory points in the organism, and advances the discussion of archaeal carbon catabolite repression (CCR) by identifying putative targets of CCR that can be probed in future work to further explore underlying mechanisms.Halophilic organisms are also suitable for use in educational settings. Here, I present the development and study examining the impact of a quantitative biology-focused Course Based Undergraduate Research Experience (CURE) on the development of student interest in and self-efficacy for quantitative biology. Students in the course isolate halophilic organisms from environmental samples, quantitatively characterize their growth, and thereafter sequence the genomes of the isolates. We found that although students initially reported high math-biology values, we saw improvements with regard to students seeing higher value in using quantitative calculations in biology and increased interest in pursuing future quantitative experiences (e.g., coursework, occupation).Lastly, I present collaborative research that explores how students express affect when they engage with one another in the context of an online course textbook-based annotation and discussion forum. This work includes efforts to use machine learning to predict student affect and better understand student confusion, to increase student engagement with the course content by seeding forums, and to create and validate a limited emoji-hashtag pair set that enables more reliable student-driven affect tagging of forum posts
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Training Interdisciplinary Scientists for Systems Biology
No full textThe rise of interdisciplinary research programs in recent years has spawned numerous questions regarding the best way to organize interdisciplinary programs and how to best train new interdisciplinary scientists in ways that will catalyze novel discoveries in biology. Systems biology, a relatively new branch of science, can be considered in many respects a poster child for modern interdisciplinary science. It not only requires that people from different traditional disciplines work closely together but it also requires the development of unique training environments to educate the next generation of systems biologists. The unique scientific and training challenges associated with the development of systems biology are certainly faced across the spectrum of interdisciplinary endeavors. Therefore, it is useful for scientists interested in building interdisciplinary research programs to consider the merits of successful systems biology initiatives. Institute for Systems Biology is one such example, and in the following, several key aspects of Institute for Systems Biology that make it both a unique and successful interdisciplinary science and training center are discussed
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