1,720,968 research outputs found
CYYR1: discovery of a new role in muscle and heart development trought generation of null mutant
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
CYYR1 gene and Hh-mediated myogenesis during zebrafish development: potential role in rhabdomyosarcoma disease
No full textCYYR1 (Cysteine/tyrosine-rich 1) cloned on HC21 defines a family of highly conserved
vertebrate-specific genes. The human locus is characterized by a multitranscript-system
including at least six alternative spliced isoforms. To date, the function of the CYYR1 product
is still unknown even if original results suggest its possible involvement in myogenesis
differentiation with a putative role in the tumorigenic process related to the Hh pathway.
Zebrafish cyyr1 orthologue is present in single copy and the predicted protein maintains
almost 58% of identity with human protein. By WISH approach, we show a cyyr1 broad
expression in central nervous system (CNS), somites and muscles during development. The
protein seems to localize in plasma and even nuclear membranes.
We perform cyyr1 knock-down with two different approaches: microinjection of morpholino
oligos targeting the ATG and the first splice-site of the transcript, and the generation of cyyr1
null fish through CRISPr/Cas9 technique. Defects in heart and muscle development with a
significant rescue in embryo co-injected with cyyr1 mRNA, were observed in morphants,
while cyyr1 mutants analyses confirmed morphological and molecular weakness in heart.
Dysregulation of Nodal and/or Hedgehog (Hh) pathways in zebrafish decreased cyyr1
expression and the injection of cyyr1 mRNA was able to partially rescue Hh-defective
phenotype in embryos. In order to verify a putative role of CYYR1 in the process caused by
dysfunction of cell differentiation we performed experiments in rhabdomyosarcoma cell
lines showing an inverse correlation between CYYR1 expression and the range of
differentiating capabilities of these cells. Interestingly, treatments with inhibitors of Hh allow
us to confirm a correlation between CYYR1 and this pathway
Interplay between CYYR1 gene and Sonic hedgehog pathway: from zebrafish myogenesis to a potential role in rhabdomyosarcoma disease
No full textCYYR1 (Cysteine/tyrosine-rich 1) cloned on human chromosome 21 defines a family of highly conserved vertebrate-specific genes. The human locus is characterized by a multitranscript-system including at least six alternative spliced isoforms and one ncRNA gene overlapping CYYR1 in antisense orientation (CYYR1-AS1). To date, the function of the CYYR1 product is still unknown even if original results suggest its possible involvement in myogenesis differentiation with a putative role in the tumorigenic process related to the Hh pathway. Zebrafish cyyr1 orthologue is present in single copy and the predicted protein maintains almost 58% of identity with human protein. By WISH approach, we show a cyyr1 broad expression in central nervous system (CNS), somites and muscles during development. The protein seems to localize in plasma membrane and even in nuclear envelope. We perform cyyr1 knock-down with two different approaches: microinjection of morpholino oligos targeting the ATG and the first splice-site of the transcript, and the generation of cyyr1 null fish through CRISPr/Cas9 technique. Defects in heart and muscle development with a significant rescue in embryo co-injected with cyyr1 mRNA, were observed in morphants, while cyyr1 mutants analyses confirmed morphological and molecular weakness in heart. Dysregulation of Nodal and/or Hh pathways in zebrafish decreased cyyr1 expression and the injection of cyyr1 mRNA was able to partially rescue Hh-defective phenotype in embryos. In order to verify a putative role of CYYR1 in process caused by dysfunction of cell differentiation we performed experiments in rhabdomyosarcoma cell lines showing an inverse correlation between CYYR1 expression and the range of differentiating capabilities of these cells. Interestingly, treatments with inhibitors of Shh allow us to confirm a correlation between CYYR1 and this pathway
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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