17 research outputs found
An italian experience of a new personalized injective protocol (Botutouch) for botulinum toxin application in aesthetic medicine
No full textBotulinum toxin typeA (BoNTA) is widely used in aesthetic medicine as primary treatment
to reduce facial wrinkles. Major unmet needs in the field of the injection techniques
include dilution factor, injected volume and site. Since 2013, an innovative
protocol has been developed in our clinic that works on a double dilution volume,
identifies the injection site according to the specific anatomical-functional characteristics
of each patient's musculature and applies a gentle massage to the injected area
to optimize the toxin spread in the muscle. We retrospectively retrieved medical
records of subjects that underwent aesthetic treatments in our outpatient Italian
clinics from 2013. In cobotulinum toxin A was used in double dilution (100 AU in
5 mL of physiologic solution) and followed by a gentle massage after the injection to
increase the distribution into the muscle. 197 subjects, most of them drug-naïve
(81.7%), underwent 869 BoNTA treatments. On average, higher total units and volumes
were applied in first visits or older subjects whereas the lower ones were preferred
in following visits or younger subjects. As perceived by the patients, the
effects of BoNTA lasted more than 6 months in about 38% of the cases. 95.9% of
subjects declared to be satisfied,whereas 5.2% of adverse events were observed
(4.8% hematoma, 0.2% ptosis, and 0.2% tenderness). To date, we offer a BoNTA
treatment with the aim to maximize the results and consequent patient's satisfaction,
with low incidence of complications
Histopathological Features of Tissue Alterations Induced by Cryolipolysis on Human Adipose Tissue
No full textBackground
Adipose tissue cooling, under controlled conditions, induces physical effects on subcutaneous tissue called cryolipolysis (CLL), which has been proposed as a method to reduce noninvasively the amount of adipose tissue. Although CLL has been widely utilized in clinical practice and many favorable results have been reported in clinical studies, very few published studies have dealt with the effects of such therapies on human adipose tissue.
Objectives
The aim of this study was to evaluate, through histopathological examination, the in vivo effects of CLL on human adipose tissue.
Methods
Six patients to be submitted to abdominoplasty were enrolled in the study. Samples were taken from the surgical patch, respectively, 15 days (2 pts), 45 days (2 pts), and 60 days (2 pts) after a single standard session of CLL. Control samples were derived from the nontreated areas of the surgical patch.
Results
Disruption of the adipocytic membranes was evident in all treated areas, with a reduction of cell dissolution in the 60-day samples. Focal dissolution and homogenization of the collagen fibers was evident, resulting in the dissolution of the interlobular fibrous septa. A mild inflammatory response was observed in the 15- and 45-day samples. Neocapillarizzation was observed in the 45- and 60-day samples.
Conclusions
The lesions demonstrated in adipocytes confirm the theoretical premises of a usefulness of CLL in the treatment of localized adiposis. The alterations in the connective stroma could lead to a structural reorganization and consequently to the in vivo external appearance of the treated areas
Dalla Resistenza alla Costituzione
No full textIl sentiero storico della Costituzione, un'analisi sugli articoli relativi ai "Principi fondamentali" della carta costituzionale visti nella cultura storica e costituzionale del tempo. Si delinea la proposta politica dell'antifascismo e l'affermazione dei diritti negati dal regime fascista. Ci si sofferma anche sull'uso dei termini "nazione", "patria", "repubblica" e sulla distinzione tra Costituzione formale e Costituzione material
Hubungan Antara Stres dengan Kepedulian pada Keluarga yang Menjadi Caregiver ODHA
No full textPenelitian ini bertujuan untuk melihat hubungan antara stres dengan kepedulian
pada keluarga yang menjadi caregiver orang dengan HIV/AIDS (ODHA).
Penelitian ini menggunakan pendekatan kuantitatif dengan metode korelasional.
Subjek pada penelitian ini adalah keluarga yang menjadi caregiver ODHA yang
dipilih dengan menggunakan teknik incidental sampling yaitu berjumlah 50
orang. Alat ukur yang digunakan adalah skala stres yang disusun berdasarkan
teori stres (Sarafino, 2011) dan skala kepedulian yang disusun berdasarkan teori
kepedulian (Swanson, dalam Tomey & Alligood, 2014). Hasil penelitian ini
menunjukkan bahwa ada hubungan negatif yang signifikan antara stres dengan
kepedulian pada keluarga yang menjadi caregiver ODHA.The purpose of this study is to determine the relationship between stress and
caring in family that was caregiver of people with HIV/AIDS (PWHA). This study
uses a quantitative approach with the correlation method. The subject of this
study is the family that was caregiver of ODHA’s, that chosen with the incidental
sampling technique that amount to 50 caregiver. Measuring instrument which
used is stress scale that compiled by the author based on stress theory (Sarafino,
2011) and the caring scale that compiled by the author based on caring theory
(Swanson, in Tomey & Alligood, 2014). The result of the data analysis of this
study showed that there is a negative relationship between stress and caring in
family that was caregiver of PWHA.Skripsi Sarjan
Hubungan Antara Stres dengan Kepedulian pada Keluarga yang Menjadi Caregiver ODHA
No full textPenelitian ini bertujuan untuk melihat hubungan antara stres dengan kepedulian
pada keluarga yang menjadi caregiver orang dengan HIV/AIDS (ODHA).
Penelitian ini menggunakan pendekatan kuantitatif dengan metode korelasional.
Subjek pada penelitian ini adalah keluarga yang menjadi caregiver ODHA yang
dipilih dengan menggunakan teknik incidental sampling yaitu berjumlah 50
orang. Alat ukur yang digunakan adalah skala stres yang disusun berdasarkan
teori stres (Sarafino, 2011) dan skala kepedulian yang disusun berdasarkan teori
kepedulian (Swanson, dalam Tomey & Alligood, 2014). Hasil penelitian ini
menunjukkan bahwa ada hubungan negatif yang signifikan antara stres dengan
kepedulian pada keluarga yang menjadi caregiver ODHA.The purpose of this study is to determine the relationship between stress and
caring in family that was caregiver of people with HIV/AIDS (PWHA). This study
uses a quantitative approach with the correlation method. The subject of this
study is the family that was caregiver of ODHA’s, that chosen with the incidental
sampling technique that amount to 50 caregiver. Measuring instrument which
used is stress scale that compiled by the author based on stress theory (Sarafino,
2011) and the caring scale that compiled by the author based on caring theory
(Swanson, in Tomey & Alligood, 2014). The result of the data analysis of this
study showed that there is a negative relationship between stress and caring in
family that was caregiver of PWHA.Skripsi Sarjan
At-home Cosmeceutical Application and Outpatient Treatments: A 3D Stepwise Facial Rejuvenation Approach
No full textBACKGROUND: Aging affects the 3-dimensional structure of all the facial tissues: Bones, muscles, ligaments, adipose tissue, and skin.
AIM: To customize minimally invasive treatments for facial rejuvenation, we present a standardized holistic approach characterized by at-home treatments in associations with outpatient procedures.
METHODS: Forty-four patients underwent 3-dimensional stepwise facial rejuvenation and were evaluated prospectively. Each patient received a customized treatment plan based on a clinical examination and consultation. Treatment outcomes were evaluated from patient photographs with and skin analysis was performed with an A-One Smart automated skin analysis system.
RESULTS: The mean age of the patients was 41.7 years and the approximate mean duration of treatment was 160 days. Patients applied cosmeceuticals such as retinoic acid. Outpatient procedures included the delivery of botulinum toxin or dermal fillers, thread lifting, chemical peels, etc. Upon treatment completion, significant improvements were noted in multiple domains: Skin elasticity and hydration increased, areas of hyper-pigmentation were less extensive, and there were fewer visible wrinkles and pores.
CONCLUSION: Outcomes of the present article suggest how important is to customize facial anti-aging treatments. Nonsurgical treatments carried out progressively, involving the patient to perform at-home treatments in associations with outpatient procedures, let to achieve facial improvements in terms of increased skin elasticity and hydration, reduction of hyperpigmentation, wrinkles, and pores
Guided SEFFI and CaHA: A Retrospective Observational Study of an Innovative Protocol for Regenerative Aesthetics
No full textBackground/Objectives: This retrospective observational study sought to determine the efficacy and safety of an innovative combined treatment protocol using guided Superficial Enhanced Fluid Fat Injection (SEFFI) and calcium hydroxylapatite (CaHA) in facial rejuvenation. Methods: A total of 158 patients (149 females and 9 males) underwent the combined treatment of guided SEFFI and diluted/hyperdiluted CaHA. The study evaluated treatment outcomes at 30, 90, and 150 days post-treatment using the Global Aesthetic Improvement Scale (GAIS) and three-dimensional photogrammetric analysis. Results: The combined treatment demonstrated consistent enhancement in skin quality and facial volume across temporal, malar, zygomatic, and jawline regions. At 90 days post-treatment, substantial improvements were observed, with the GAIS scores reflecting significant enhancements in both skin quality and volume, which were sustained or slightly improved by 150 days. Minor complications, predominantly ecchymosis at the injection sites, resolved within a week, confirming the treatments’ safety. Conclusions: The integration of guided SEFFI and CaHA resulted in significant improvements in skin quality and facial volume with minimal complications. Further research is recommended to consolidate these findings and explore long-term outcomes
THE RELATIONSHIP BETWEEN GADGET USE AND DIGITAL LITERACY IN BIOLOGY EDUCATION STUDENTS OF HKBP NOMMENSEN UNIVERSITY
No full textAbstract: Technology and information have progressed quite rapidly, as seen from the emergence of gadgets as a means of communication. Given the importance of digital literacy in responding to what is obtained from the internet, the author wants to see how the relationship between the use of gadgets and digital literacy in biology education students at HKBP Nommensen University Pematangsiantar. The sample was taken by the purposive sampling method with students majoring in biology education at HKBP Nommensen Pematangsiantar university as a sample. The purpose of this study is to analyze the relationship between the use of technology and digital literacy in biology students HKBP Nommensen University Pematang Siantar which often utilizes technology. The research method uses qualitative research methods and saturated sampling strategies. Google Form surveys with Likert scale are used to collect data. Judging from the survey, Generation Z is currently more dominant in watching videos than literate through e-books with a percentage rate of 78.4%. The low digital literacy among Generation Z is influenced by the wrong use of gadgets. There is a close relationship between digital literacy and the use of gadgets, namely using gadgets to find existing sources to increase one\u27s insight and ability to improve quality in oneself.
Keywords: gadgets; digital literacy, biology students, HKBP Nommensen University Pematang Siantar
Abstrak: Teknologi dan informasi mengalami kemajuan yang cukup pesat, terlihat dari munculnya gadget sebagai alat komunikasi. Mengingat pentingnya literasi digital dalam menyikapi apa yang di dapat dari internet maka penulis ingin melihat bagaimana hubungan penggunaan gadget dengan literasi digital pada mahasiswa pendidikan biologi di Universitas HKBP Nommensen Pematangsiantar. Sampel diambil dengan metode purposive sampling dengan mahasiswa jurusan pendidikan biologi di universitas HKBP Nommensen Pematangsiantar sebagai sampel. Tujuan penelitian ini adalah untuk menganalisis hubungan antara penggunaan teknologi dan literasi digital pada Mahasiswa Universitas HKBP Nommensen Pematangsiantar yang sering memanfaatkan teknologi. Adapun metode penelitian ini menggunakan metode penelitian kualitatif dan strategi sampling jenuh. Survei Google Form dengan skala Likert digunakan untuk mengumpulkan data. Dilihat dari survei tersebut bahwa generasi Z saat ini lebih dominan senang melihat video daripada berliterasi melalui e-book dengan tingkat presentase 78,4%. Rendahnya literasi digital di kalangan generasi Z dipengaruhi oleh penggunanan gadget yang salah. Terdapat hubungan yang erat antara literasi digital dengan penggunaan gadget yaitu menggunakan gadget untuk mencari sumber -sumber yang ada untuk meningkatkan wawasan serta kemampuan seseorang guna meningkatkan kualitas dalam dirinya.
Kata kunci: gadget; literasi digital; mahasiswa pendidikan biologi, Universitas HKBP Nommense
Risk Factors for Transient Hypoparathyroidism after Total Thyroidectomy: Insights from a Cohort Analysis
No full textBackground: Transient hypoparathyroidism (TH) is the main post-thyroidectomy complication, significantly impacting surgical outcomes, hospitalization length, and perceived perceived quality of life understood as mental and physical well-being. This study aims to identify possible associated risk factors. Methods: We analyzed 238 thyroidectomies (2020–2022), excluding instances of partial surgery, primary hyperparathyroidism, neck irradiation history, and renal failure. The variables considered were as follows: demographics, histology, autoimmunity, thyroid function, pre- and postoperative Vitamin D levels (where available), type of surgery, number of incidentally removed parathyroid glands (IRP), and surgeons’ experience (>1000 thyroidectomies, <500, in training). Univariate analysis applied: χ2, Fisher’s exact test for categorical variables, and Student’s t-test for continuous variables. Subsequently, logistic multivariate analysis with stepwise selection was performed. Results: Univariate analysis did not yield statistically significant results for the considered variables. The ‘No Complications’ group displayed a mean age of 55 years, whereas the TH group showed a mean age of 51 (p-value = 0.055). We considered this result to be marginally significant. Subsequently, we constructed a multivariate logistic model. This model (AIC = 245.02) indicated that the absence of incidental parathyroidectomy was associated with the age class >55 years, presenting an odds ratio (OR) of 9.015 (p-value < 0.05). Simultaneously, the age class >55 years exhibited protective effects against TH, demonstrating an OR of 0.085 (p-value < 0.01). Similarly, the absence of incidental parathyroidectomy was found to be protective against TH, with an OR of 0.208 (p-value < 0.01). Conclusions: Multivariate analysis highlighted that having “No IRP” was protective against TH, while younger age was a risk factor. Surgeon experience does not seem to correlate with IRP or outcomes, assuming there is adequate tutoring and a case volume close to 500 to ensure good results. The effect of reimplantation has not been evident in transient hypoparathyroidism
Development and testing of a collision avoidance algorithm for industrial applications
No full textSafe interaction of the operator and the cobot in the co-working space is one fundamental requirement for introducing automation in small and medium enterprises characterized by unstructured cell layouts. In addition to the exploitation of cobots, a fully safe interaction requires the adoption of collision avoidance systems, to enable the real-time re-planning of the end-effector trajectories thus avoiding to stop the machine in case of collision with humans. This is fundamental for industrial applications, in order to maintain the production rate as constant as possible even in unstructured production environments. However, collision avoidance applications in actual industrial production cells are still limited, due to some limitations which are not yet completely solved. It is indeed still likely to happen that the recalculation of the obstacle-free trajectory takes a too long time, not compatible with industrial applications. This paper describes the development of a collision avoidance program using the Lazy PRM∗ algorithm. The program is tested on a physical robot, the Mitsubishi Melfa RV-5AS-D, to perform some exemplary pick and place tasks. The developed algorithm can alter online, during the execution, the road-map from dense to sparse in those cases in which the search for an alternative trajectory is detected to take too long time. Compared to other commercial collision avoidance systems, in which the evaluation of road-maps can only be done offline once and for all, this feature would prevent the robot to get stucked in case a feasible solution is not found in a fast enough way. Furthermore, the developed program guarantees greater flexibility in creating the road-map, trying to match the user's needs, and eliminating the superfluous parts of the road-map to reduce computational time. This marks a difference with present-day solutions for commercial collision avoidance systems which, to the author knowledge, connects all the nodes together
