287 research outputs found
A different use of patellar pubic percussion test (PPPT) to identify an unrecognized hip stress fracture
No full textThe Ten Commandments in Old Frisian: Their Form and Content
No full textThis study discusses the relationship amongst the five surviving versions of the Ten Commandments in Old Frisian, which are collectively preserved in eight manuscripts and in one incunable. These versions do not follow the Vulgate text verbatim, but rather include interferences from other texts. As the author intends to show, the compiler of the version of the Ten Commandments in the First Rüstring Manuscript aimed to produce a comprehensive list of precepts by including the Great Commandment, and had a source close to Honorius’s De decem plagis Aegypti spiritualiter at their disposal. The text in Haet is Riocht? may have influenced the vernacular rendition of the Mosaic Law preserved in Codex Aysma. Lastly, the versions preserved in the First and Second Hunsingo Manuscripts and one of the two versions attested by Codex Unia seem to be independent translations of a single Latin text, which survives in Unia
Ancient pottery from archaeological sites in southern Italy: First evidence of red grape product markers
No full textThe chemical analysis of tartaric acid (TA) and syringic acid (SA), as grape product markers in ancient ceramic vessels from the sites of Manduria and Torre di Satriano (southern Italy), was successfully performed. Firstly, the fragmentation behaviour of TA and SA as deprotonated molecules, [M-H]-, obtained by collision-induced dissociation, was investigated. Then, reversed-phase liquid chromatog-raphy (RPLC) with electrospray ionization (ESI) in negative ion mode, using a quadrupole linear ion trap in multiple reaction monitoring (MRM), was employed. A binary mobile phase composed of water-acetonitrile with 0.1% (v/v) acetic acid enabled the optimum ESI effciency of SA, greatly improving its identifcation when it occurs in trace amounts. Chemical analysis of ancient pottery fragments is a valid method for establishing the existence of preserved organic residues, which is valuable new evidence for the culture and customs of ancient populations, in this case those of southern Italy. The proposed RPLC-ESI-MRM method allowed a systematic investigation of ceramic fragments of both archaeological sites, thus providing positive evidence for the presence of TA and SA as grape product markers in storage vessels dating back to the ninth to third centuries BC
A Study of the Alfredian Verse Prefaces and Epilogues
No full textThis study takes into account the verse prefaces and epilogues associated with the translations of the Alfredian age, approaching them from a metrical standpoint. As I hope to demonstrate, both the Metrical Preface and the Metrical Epilogue to Alfred’s translation of Gregory’s Pastoral Care fit the style of classical Old English poetry. Their author – be it Alfred or one of the scholars that convened at his court – was well-acquainted with the rules governing the traditional alliterative verse. The same applies to the brief Metrical Preface to the Old English Boethius. On the other hand, the Metrical Preface to Wærferth’s translation of Gregory’s Dialogues displays features (such as lack of enjambement and anaphora) that are typical of late Old English poetry. These and other features suggest that this preface might be a late forgery, which was possibly inspired by similar Alfredian examples. This interpretation would fit with the date of the only manuscript where Wærferth’s translation of Gregory’s Dialogues is accompanied by a preface (the eleventh century). The Metrical Epilogue to the translation of Bede’s Ecclesiastical History, which is also preserved in a single, eleventh-century copy, is characterised by the presence of similar features. According to this understanding, the Alfredian prologues and epilogues can be read as examples of the development of Old English poetry from early to late versification
A Re-assessment of Poema Morale and its influence on Penitence for a Wasted Life
No full textThe aim of this study is to re-assess the possible influence of Poema Morale on the slightly later lyric Penitence for Wasted Life. The intention is to consider both the content and metre of the two works. Previous scholarship has noted that Penitence for Wasted Life is thematically close to the early Middle English poem; as I shall show, this debt extends to metre as well. A wise old man’s reflection on the transience of worldly things, Poema Morale displays a fondness for proverbial sayings and vivid descriptions of heaven and hell – all elements that must surely have appealed to the Early Middle English readership. This appeal is attested to not only by the nine manuscripts in which the poem is preserved, but also by several textual borrowings from Poema Morale in a number of thirteenth-century lyrics, which were noted by previous scholarship. In this study, I shall suggest that, amongst these lyrics, Penitence for Wasted Life seems inspired by a specific section of Poema Morale, and that several previously unnoticed metrical correspondences between the two works actually indicate that the author of Penitence for Wasted Life possessed a first-hand knowledge of the twelfth-century poem
Balance between cell division and cell death as predictor of survival in patients with non-small-cell lung cancer
No full textOBJECTIVE:
To evaluate the prognostic value of the balance between apoptosis and proliferation in non-small-cell lung cancer (NSCLC).
METHODS:
Paraffin-embedded sections from a consecutive series of radically resected NSCLCs were scored for apoptosis (in situ DNA nick end labeling assay) and proliferation (immunohistochemistry for MIB-1). A total of 1,000 cells were counted per case, to obtain apoptotic (AI) and MIB-1 indices. Other potential prognostic indicators (pT, pN, pStage and histology) and p53 status were also evaluated.
RESULTS:
Univariate analysis showed that adenocarcinomatous histotype (p = 0.03), nodal involvement (p = 0.04), higher pStage (p = 0.001) and the combination of low AI and high MIB-1 expression (p = 0.03) were associated with poorer outcome. The significant prognostic value of the combination 'low AI/high MIB-1' was also confirmed in a multivariate analysis after adjustment for other covariates.
CONCLUSION:
These results underline the importance of considering apoptosis and proliferation together to identify a subgroup of NSCLC associated with poor survival
SOLIDARIETÀ ED EQUITÀ SOCIALE NELL’UNIONE EUROPEA A SETTANT’ANNI DALLA DICHIARAZIONE UNIVERSALE DEI DIRITTI UMANI:IL RUOLO DEI GIUDICI EUROPEI
No full textSeventy years after its proclamation, the Universal Declaration of Human Rights, despite not having a binding force for the states, still provides at international level the fundamental text from which the principles and the values for the preservation of liberty and right of people are taken. In this article, the author particularly underlines the importance of Declaration’s Article 1, which states: “All human beings are born free and equal in dignity and rights”. With these words the Declaration presses states to undertake economic policies aimed at achieving economic and social progress for all individuals. Unfortunately, we also have to underline the lack of effective social policies in government programs of the E.U. Member States. The author inquires whether it is left to European judges to affirm the importance of social welfare
Lack of correlation between immunohistochemical expression of E2F-1, thymidylate synthase expression and clinical response to 5-fluorouracil in advanced colorectal cancer
No full textBackground: The level of the enzyme thymidylate synthase (TS) is known to inversely correlate with the clinical activity of 5-fluorouracil (FU) in advanced colorectal cancer patients. Since the correlation is not very strong, we have retrospectively analyzed the expression of E2F-1 in tumor samples or metastases from 25 patients with advanced colorectal cancer, homogeneously treated with an FU-based regimen. E2F-1 is a transcription factor regulating the expression of TS along with other crucial DNA synthesis related enzymes. Materials and methods: E2F-1 expression was analyzed by immunohistochemistry using the anti-E2F-1 monoclonal antibody KH95, scoring 2000 cells/case. Expression of TS was evaluated by immunohistochemistry using a rabbit anti-human polyclonal antibody. Results: The level of E2F-1 expression did not correlate with TS expression, although a trend for correlation between E2F-1 level and maximal tumor shrinkage was observed (r = 0.42; P = 0.054). Conclusions: in spite of previous reports demonstrating that E2F-1 quantified by rt-PCR and western blot correlates with TS and could be used as a predictor to select colorectal cancer patients more likely to respond to FU treatment, our data suggest that, under these experimental conditions, immunohistochemistry cannot be used for such selection
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