3,607 research outputs found
The Evolution of Landscape and Settlement Transformations in the 18th Municipium of Rome's Suburbium: A Weighted Average Analysis
No full textThe aim of this paper is to reconstruct the evolution of the landscape in the 18th Municipium of the Suburbium of Rome between the 8th century B.C. and the 7th century A.D. This will be based on the analysis of a detailed and extensive documentary dossier of the surveys carried out between 1993 and 2003 as part of the project 'Archaeology of the Suburbium of Rome' by the Department of Classical Archaeology of the University of Rome 'La Sapienza', under the scientific direction of Andrea Carandini.
The method of weighted averaging was chosen for analysing the pottery in order to estimate in a statistically reliable way the amount of pottery in each of the topographic units over a given period, taking into account the approximate or exact date of each of the fragments collected.
The method used produces graphs that make it possible to understand the evolution of the settlement in the XVIII Municipium, based on the distribution of wares in the area by chronological phases, through the processing of data on a GIS platform. The comparison between the graphs produced with weighted averages and those related to the evolution of the landscape allows for the examination, for example, of settlement changes linked to main historical events, visible in the evolution of the topographical units, as reflected in the changes in the attestation curves of the main ceramic classes. It is possible to determine whether periods of peak development in the number of TUs are associated with periods of particular dynamism in production and trade, or whether periods of decline in the number of TUs are associated with a decline in the quantity of products
Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
No full textMost older individuals develop inflammageing, a condition characterized by elevated levels of blood inflammatory markers that carries high susceptibility to chronic morbidity, disability, frailty, and premature death. Potential mechanisms of inflammageing include genetic susceptibility, central obesity, increased gut permeability, changes to microbiota composition, cellular senescence, NLRP3 inflammasome activation, oxidative stress caused by dysfunctional mitochondria, immune cell dysregulation, and chronic infections. Inflammageing is a risk factor for cardiovascular diseases (CVDs), and clinical trials suggest that this association is causal. Inflammageing is also a risk factor for chronic kidney disease, diabetes mellitus, cancer, depression, dementia, and sarcopenia, but whether modulating inflammation beneficially affects the clinical course of non-CVD health problems is controversial. This uncertainty is an important issue to address because older patients with CVD are often affected by multimorbidity and frailty - which affect clinical manifestations, prognosis, and response to treatment - and are associated with inflammation by mechanisms similar to those in CVD. The hypothesis that inflammation affects CVD, multimorbidity, and frailty by inhibiting growth factors, increasing catabolism, and interfering with homeostatic signalling is supported by mechanistic studies but requires confirmation in humans. Whether early modulation of inflammageing prevents or delays the onset of cardiovascular frailty should be tested in clinical trials
Risposte comportamentali di Liriomyza trifolii e Diglyphus isaea a semiochimici emessi da piante di fagiolo danneggiate dal fillominatore
No full textFormazione e riflessione pedagogica per la figura traguardo del medico. Tra soft skills, umanizzazione e personalizzazione della medicina
No full textIl contributo della pedagogia al “prendersi cura” non è ravvisabile solo all’interno
di processi riflessivi, ma anche attraverso le pratiche formative coniugando saperi
e prassi. In un orizzonte sociale che tende a separare e allontanare la malattia dal
quotidiano, si diffondono modelli formativi che prediligono la trasmissione di saperi
tecnico-operativi, necessari ma non sufficienti per educare alle figure traguardo
della cura. La domanda che viene rivolta alla formazione è quindi quella di progettare
processi formativi sensibili all’incontro dell’altro nella relazione tra medico e paziente
Recensione di: Paolo Fabbri, Proposte di adozione. Problemi di semiotica generale, a cura di G. Marrone, Palermo, Edizioni Museo Pasqualino, 2024 (pp. 282)
No full textSome readers skip over them, deeming them unimportant; others focus on them exclusively, convinced that the part is worth the whole. Some quickly skim through them, impatient to discover what lies ahead, while others read them meticulously but only at the end, perhaps hoping to find answers. These varied attitudes unite many readers when confronted with introductions, prefaces, and afterwords—elements that, since Genette, we have come to call paratextual.
But what happens when such texts are extracted from their original works and compiled into a new volume? This is precisely the case with Proposals for Adoption. Problemi di semiotica generale, which gathers around thirty writings by Paolo Fabbri, some of which were previously difficult to access. These are not essays stricto sensu but rather introductions, prefaces, and afterwords written between 1986 and 2019. Before being curated into this volume by Gianfranco Marrone, these writings often accompanied semiotic texts or works relevant to the discipline, many of which were first presented to Italian readers under Fabbri's editorial guidance.
The underlying premise is clear: these writings still have something to say—something that transcends mere commentary or explanation of the diverse and multifaceted works they originally accompanied
Direct replacement of antibodies with molecularly imprinted polymer (MIP) nanoparticles in ELISA - development of a novel assay for vancomycin
No full textA simple and straightforward technique for coating microplate wells with molecularly imprinted polymer nanoparticles (nanoMIPs) to develop ELISA type assays is presented here for the first time. NanoMIPs were synthesized by a solid phase approach with immobilized vancomycin (template) and characterized using Biacore 3000, dynamic light scattering and electron microscopy. Immobilization, blocking and washing conditions were optimized in microplate format. The detection of vancomycin was achieved in competitive binding experiments with a HRP-vancomycin conjugate. The assay was capable of measuring vancomycin in buffer and in blood plasma within the range 0.001-70 nM with a detection limit of 0.0025 nM (2.5 pM). The sensitivity of the assay was three orders of magnitude better than a previously described ELISA based on antibodies. In these experiments nanoMIPs have shown high affinity and minimal interference from blood plasma components. Immobilized nanoMIPs were stored for 1 month at room temperature without any detrimental effects to their binding properties. The high affinity of nanoMIPs and the lack of a requirement for cold chain logistics make them an attractive alternative to traditional antibodies used in ELIS
Solvent and substrate contributions to the formation of Breath Figures Patterns in Polystyrene Films
No full textThe generation of ordered porous polymer structures by the breath figures (BFs) method has long been described as a complex phenomenon, in which several parameters combine in a fairly unknown way. Kind of polymer and solvent, degree of humidity and additives are just a few examples of the several parameters that have been described as playing a role in the generation of BFs. This work reports a detailed investigation over the role played by the solvent in the process of BFs generation from polystyrene (PS) solutions spread over different substrates, and discuss the geometrical aspects of the pores by a quantitative point of view by using a purposely developed software for image analysis. Results show that thermodynamic affinity between polymer and solvent is the key parameter for BFs formation, along with other solvent characteristics such as water miscibility, boiling point and enthalpy. According to our findings, the role played by the substrate is strictly related to the type of solvent used in the generation of BFs
Cooking ware from the excavation of a 5th-7th century context in Classe (Ravenna, Italy)
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