1,354,843 research outputs found
Recommended from our members
Cytenamide-1,4-dioxane (2/1)
No full textIn the crystal structure of the title compound [systematic name: 5H-dibenzo[a,d]cycloheptatriene-5-carboxamide-1,4dioxane(2/1)], 2C(16)H(13)NO center dot C4H8O2, the cytenamide molecules form a hydrogen-bonded R-2(2)(8) dimer. The solvent molecule is located between two adjacent cytenamide dimers and forms N-H center dot center dot center dot O hydrogen bonds with one cytenamide molecule from each dimer
Nuevas recomendaciones para el uso de AINE tópicos en osteoartritis
No full textBr. Guillermo Morinelli: Ayudante de clase. -- Dr. Stefano Fabbiani: Coord. CCGI - Facultad de Medicina.Los antiinflamatorios no esteroideos (AINE) constituyen uno de los grupos farmacológicos más prescritos a nivel mundial, siendo un grupo heterogéneo de compuestos que presentan actividad analgésica, antiinflamatoria y antipirética. Su percepción de bajo riesgo sumado a la venta libre y a una automedicación elevada con este grupo terapéutico determina un alto uso de estos medicamentos
Structural Elucidation of α-Cyclodextrin-Succinic Acid Pseudo Dodecahydrate: Expanding the Packing Types of α-Cyclodextrin Inclusion Complexes
No full textThis paper reports a new packing type of α-cyclodextrin inclusion complexes, obtained here with succinic acid under low-temperature crystallization conditions. The structure of the 1:1 complex is characterized by heavy disorder of the guest, the solvent, and part of the host. The crystal packing belongs to the known channel-type structure; the basic structural unit is composed of cyclodextrin trimers, as opposed to the known isolated molecular or dimeric constructs, packed along the c-axis. Each trimer is made of crystallographically independent molecules assembled in a stacked vase-like cluster. A multi-temperature single-crystal X-ray diffraction analysis reveals the presence of dynamic disorder
Probing the structure of framework materials by high pressure and the example of a magnetic, non-porous coordination polymer
No full text
Guías de práctica clínica: evidencia versus consenso de expertos
No full textDr. Stefano Fabbiani Pérez: Coord. CCGI - Facultad de Medicina.La comunidad científica se encuentra cursando un modelo de medicina basada en evidencia (MBE), que determina que el uso de cualquier medicamento en la práctica clínica debe basarse en criterios de eficacia probados en estudios que sigan el método científico. Los ensayos clínicos controlados, las revisiones sistemáticas y los metaanálisis son la base del conocimiento en la terapéutica y son los pilares de la MBE.
El surgimiento constante e inabarcable de una excesiva cantidad de información; o infodemia, como ha denominado a este fenómeno la Organización Mundial de la Salud (OMS)1, provoca que los profesionales sanitarios tengan dificultad en encontrar fuentes confiables de información. Encuadrado en este exceso y superfluidad de literatura médica, altos costos en atención sanitaria y desigualdad en la accesibilidad a los medicamentos, en la década de los 90 surgen las guías de práctica clínica para intentar consensuar la información.
Las Guías de Práctica Clínica (GPC) son guías farmacoterapéuticas que tienen como objetivo asistir a la toma de decisiones de los profesionales de la salud y pueden incluso utilizarse como insumo para el diseño de políticas sanitarias, por lo que el número de GPC es vasto y va en aumento. Han demostrado ser una medida que mejora los resultados de los pacientes y su evolución clínica y contribuyen al uso racional de medicamentos.
Las GPC constituyen un algoritmo que orienta a los clínicos en el diagnóstico y la selección de la estrategia terapéutica “individualizada” (o no?) a partir de la evidencia con la mejor relación beneficio/riesgo. Se elaboran a partir de la búsqueda, recopilación y análisis de la evidencia disponible y el estado del arte sobre el tema en cuestión, y establece una serie de recomendaciones sobre el abordaje diagnóstico y terapéutico
Ambiente e turismo : atti II congresso nazionale ARIPT e XI congresso nazionale del comitato scientifico Psicologia del turismo
No full textRecommended from our members
Cytenamide trifluoroacetic acid solvate
No full textCytenamide forms a 1:1 solvate with trifluoroacetic acid (systematic name: 5H-dibenzo[a, d] cycloheptatriene-5-carboxamide trifluoroacetic acid solvate), C16H13NO center dot C2HF3O2. The compound crystallizes with one molecule of cytenamide and one of trifluoroacetic acid in the asymmetric unit; these are linked by O-H center dot center dot center dot O and N-H center dot center dot center dot O hydrogen bonds to form an R-2(2)(8) motif. The trifluoromethyl group of the solvent molecule displays rotational disorder over two sites, with site-occupancy factors of 0.964 (4) and 0.036 (4)
RB1 Germline Variant Predisposing to a Rare Ovarian Germ Cell Tumor: A Case Report
No full textMalignant ovarian germ cell tumors (MOGCTs) are neoplasms of the ovary, of which, due to their rarity and heterogeneity, few is reported about genetic background and development. Here, we report a 18-years old patient diagnosed with an ovarian mixed germ cell tumor, without any previous history of malignancies, who has been treated with surgery and chemotherapy and died 4 years later due to peritoneal metastasis complications. Patient's blood DNA was screened for a panel of 52 cancer-related genes in order to identify predisposing aberrations to this rare cancer. The analysis discovered the uncharacterized c.2393G>A variant in RB1, the retinoblastoma gene, leading both to a missense change and a splicing perturbation of the RB1 transcript. The variant was found to be hypomorphic, damaging the C-terminal domain with a partially impaired protein function. The variant is inherited from the unaffected mother. Due to an imprinting mechanism, the maternal allele is ~3-fold more expressed than the paternal one. The parent-of-origin effect combined with the hypomorphic impact of the variant determines a rescue of sufficient tumor-suppressor activity to prevent retinoblastoma development but can predispose to other cancers in the adult age. In order to understand the somatic events acting on the germline predisposition we used the NGS-liquid biopsy covering 77 cancer driver genes. Using this approach, we detected deleterious mutations in TP53, SMAD4, FGFR3, and MSH2, indicative of a dis-regulation of cell cycle and DNA repair mechanisms pathways. In conclusion, we have pinpointed for the first time that an RB1 leaky variant, not leading to retinoblastoma because of its maternal origin, can predispose in adults to a very rare form of ovarian cancer and that the somatic disruption of few genes contributes to the tumor progression and aggressiveness. © 2020 Gelli, Fallerini, Valentino, Giliberti, Castiglione, Laschi, Palmieri, Fabbiani, Tita, Mencarelli, Renieri and Ariani
- …
