1,721,043 research outputs found
Follicular variant of papillary carcinoma: cytologic findings on FNAB samples-experience with 16 cases
No full textHodgkin's disease mimicking suppurative lymphadenitis: a possible pitfall in fine-needle aspiration biopsy cytology.
No full textWe report one case of nodular sclerosing Hodgkin's disease with uncommon pseudosuppurative presentations in fine-needle aspiration biopsy (FNAB) samples and on histopathologic material. The criteria for cytologic diagnosis include atypical mononuclear cells and diagnostic SR cells in the purulent exudate. This lesion is considered a possible pitfall in FNAB cytology of Hodgkin's disease
Detecting N-RAS Q61R Mutated Thyroid Neoplasias by Immunohistochemistry
No full textRecently, the immunohistochemistry (IHC) for N-RAS Q61R has been developed and commercialized for clinical practice. Here, we investigated the reliability of IHC to identify N-RAS Q61R mutated thyroid neoplasia. A series of 24 consecutive thyroid lesions undergone surgery following indeterminate cytology were enrolled. Paraffin sections were stained for IHC using the rabbit monoclonal anti-human N-RAS Q61R, clone SP174. N-RAS mutations in codon 61 were also investigated by automated sequencing. At histology, 12 cases of follicular carcinoma, cytologically defined as follicular lesions, 1 papillary cancer, 7 follicular adenomas, and 4 hyperplastic nodules were found. Of these, 4 showed a positive IHC for anti N-RAS antibody where N-RAS expression was detected mainly at cytoplasmic level with similar intensity of reaction. The remaining cases had negative IHC. A 100% concordance between IHC and molecular analysis for N-RAS Q61R was observed. In conclusion, this study shows high reliability of IHC to identify N-RAS Q61R mutated thyroid lesions with high cost-effectiveness. These data indicate the reliability of IHC to identify N-RAS Q61R mutated thyroid neoplasia and suggest to adopt this approach for a more accurate management of patients, when indicated
Fnab plus other methods enhances diagnosis of lung ca.
No full textCombined useof fine needle aspiration biopsy(FNAB) with bronchial washing, brushing and forceps biopsy increase diagnostic accuracy in lung cance
Accuracy of fine needle aspiration biopsy in head and neck tumors.
No full textPURPOSE:
Fine-needle aspiration biopsy (FNAB) is frequently used in the diagnosis of lesions occurring in the head and neck region. This study evaluated the correlation between the findings on FNAB and the histological findings observed after surgery.
MATERIALS AND METHODS:
A review of 218 patients who underwent FNAB of a head or neck tumor was performed. Cytological reports were classified into the following diagnostic categories: negative or positive for malignant cells and unsatisfactory. False-positive, false-negative, true-positive (sensitivity), and true-negative (specificity) rates were calculated.
RESULTS:
Twelve specimens did not allow an adequate diagnosis (5.5%). Among benign tumors, 96.2% of the cases were correctly diagnosed, and 3.8% were nondiagnostic specimens. Among malignant tumors, 86.4% of cases were correctly identified. There were two (3.4%) false-negatives and six (10.2%) nondiagnostic specimens, with a total false-negative rate of 13.6%.
CONCLUSIONS:
Sampling errors present a minor problem with FNAB. Most nondiagnostic or incorrect specimens were caused by nonhomogenous lesions, with poor placement of the needle and an insufficient amount of aspirated material. FNAB is a useful modality for the diagnosis of head and neck masses
Chondroblastoma of the temporomandibular joint – case report with cytopathologic and histopathologic study.
No full textIntrathoracic extramedullary hematopoiesis. Report of a case in a patiente with hereditry spherocytosis.
No full textLo studio riguarda un caso di ematopoiesi extramidollare intratoraica
Massive infarction of papillary carcinoma of the kidney after fine needle aspiration biopsy: report of a case with cytohistologic correlation.
No full textPreliminary study of E-cadherin,beta and gamma-catenin and MMp-2 expression in morphological variants af differentiayed thyroid cancer
No full textIn the present study we documented significant higher E-cadherin,beta and gamma catenin expression in non-aggressive morphological variants of differentiated thyroid cancer as compared with aggressive variants
Pathological study of mesothelioma:role of the cytopatologist and the histopathologist
No full textCytopathologic and histopathologic examination of cellular and tissue samples from serous effusions still constitute a powerful diagnostic and prognostic tool in the pathology of mesotheliom
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