1,721,124 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Social cognition in borderline personality disorder : an MRI investigation
No full textTHESIS 10197There is increasing evidence for subtle changes in brain morphology and function in patients with borderline personality disorder (BPD). The four study arms in this thesis seek to investigate the differences in personality, brain structure, and functional connectivity, behavioural and neural responses to Theory-of-Mind (ToM) stimuli
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Functional neural differences in emotional regualtion between patients with MDD and healthy controls in the context of the vulnerability factors : family history of MDD, BDNF Val66Met polymorphism
No full textTHESIS 9893Emotional regulation is a key mechanism which shows disturbances during major depressive disorder (MDD), and which may be modified by certain factors enhancing vulnerability to MDD. Two vulnerability factors were tested in this study: family history of MDD and Val66Met gene polymorphism (rs6265). In previous research, both factors have been found to have a connection to emotional regulation, and therefore to represent modifiers of vulnerability to MDD
The role of FKBP5 genetics and epigenetics in mediating the effects of early life adversity on emotional processing brain regions in major depressive disorder
No full textMajor depressive disorder (MDD) is the most widespread psychiatric illness and is characterized by loss of pleasure, depressed mood, sleep disturbances and anxiety. Recently, an inflammatory theory of MDD has emerged, which postulates that chronic dysregulation of the stress hormone axis and increased inflammation might be crucial in the pathogenesis of the disorder. MDD also shows genetic high-heritability. In particular, the gene coding for FKBP5, a glucocordicoid receptor regulator protein, could play a role in vulnerability to MDD, especially in the presence of chronic environmental stressors such as childhood maltreatment.
Magnetic resonance imaging (MRI) is a safe and non-invasive technique that allows the investigation of the brain in vivo by using powerful magnetic fields. MDD patients show volume reduction, grey matter loss and altered function in regions that are crucial for emotional regulation.
The aim of our project was to investigate how genetics of FKBP5 and childhood adversity might interact to explain structural and functional brain abnormalities in MDD patients. For this, we conducted studies on a database collected across two sites comprising a total of 104 MDD patients and 97 healthy controls.
First of all, we investigated which changes in activation and functional coupling were associated with MDD during an MRI task involving directing attention towards and away from the valence of emotional stimuli.
Secondly, we investigated whether patients carrying the high-risk allele of the rs1360780 FKBP5 functional single nucleotide polymorphism showed differential activation during our task conditions compared to patients without genetic risk. We then sought to determine if these changes were mirrored by structural modifications and tested whether these could be explained by the interaction between genetic risk and exposure to childhood trauma.
Thirdly, we investigated epigenetic modifications of the FKBP5 gene in depressed patients and controls. Previous studies have hypothesised that chronic stress might functionally regulate FKBP5 by methylation of its regulatory sites. We tested whether this modification was related to childhood adversity as well as to reduced grey matter and altered function in emotional processing areas.
Our results have confirmed that MDD patients show differences in activation in regions involved in emotional recognition. Functional connectivity between some of these areas was also altered, in particular in trials involving regulation of negative emotions and recognition of positive ones. Furthermore, we have shown that in patients carrying the high-risk allele of rs1360780, demethylation of the intron sites of the FKBP5 gene promoter was correlated with the amount of early life maltreatment endured. Therefore, we suggest that the presence of both genetic and environmental risk factors is able to produce lasting epigenetic changes in a gene that has a prominent role in glucocorticoid receptor regulation. Childhood maltreatment also explained structural differences in temporal lobe white matter between MDD carrying different alleles of rs1360780. In addition to this, across our studies we have identified the inferior frontal lobe as a region whose structure and function are influenced by both FKBP5 allelic status and methylation. Crucially, this area was less active during emotional recognition in MDD compared to controls and its activation was inversely correlated with depression severity.
Taken together, findings across our three studies provide evidence that the gene coding for the glucocorticoid regulator FKBP5 protein is a convergence point for the interplay between genetic and environmental risk factors of MDD
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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