130,490 research outputs found
Farmacologia e Infiltrazioni
No full textLo scopo della terapia dell’osteoartrosi è di ridurre il dolore, la rigidità e di miglio- rare la funzione. L’infiammazione accompagna spesso l’OA ed è appropriato consi- derare l’uso dei FANS come terapia di prima scelta. Minori rischi di eventi tossici gastrointestinali sono stati ottenuti dai farmaci inibitori selettivi della COX-2. Le altre terapie farmacologiche sono classificate in due classi: farmaci Symptom- modifying (SYSADOAs) e Disease-modifying (DMOADs). Il termine SYSADOA ha un significato generico e comprende farmaci come la Glucosamina Solfato, altri composti simili e l’Acido Ialuronico. La terapia intra-articolare con corticosteroidi dà un beneficio di breve durata. L’HA induce una remissione del dolore per diversi mesi e prove sperimentali dimostrano anche un ruolo disease-modifying sulle strut- ture articolari malate
The role of hyaluronic acid injection for the treatment of tendinopathy
No full textHyaluronic acid has carved out an essential, though sometimes discussed, role in the treatment of joint degenerative pathology. Recent studies, first in vitro, then preclin-ical, have paved the way for use in tendon pathology. Clinical experience to date has shown extremely encouraging results in different tendinopathy frameworks such as tenosynovitis, insertional tendinopathies and tendon mid-portion
Low Molecular Weight Hyaluronic Acid (500–730 Kda) Injections in Tendinopathies—A Narrative Review
No full textTendinopathies are common causes of pain and disability in general population and athletes. Conservative treatment is largely preferred, and eccentric exercise or other modalities of therapeutic exercises are recommended. However, this approach requests several weeks of consecutive treatment and could be discouraging. In the last years, injections of different formulations were evaluated to accelerate functional recovery in combination with usual therapy. Hyaluronic acid (HA) preparations were proposed, in particular LMW-HA (500-730 kDa) for its unique molecular characteristics in favored extracellular matrix homeostasis and tenocyte viability. The purpose of our review is to evaluate the state-of-the-art about the role of 500-730 kDa in tendinopathies considering both preclinical and clinical findings and encourage further research on this emerging topic
Comparison of 2 Hyaluronic Acid Drugs for the Treatment of Temporomandibular Joint Osteoarthritis.
No full textPurpose: To compare the effectiveness of 2 treatment protocols providing 5 weekly temporomandibular joint (TMJ) arthrocenteses immediately followed by injections of 2 different molecular weight hyaluronic acid (HA) drugs to manage symptoms in patients with inflammatory-degenerative TMJ disease. Materials and Methods: Patients with a Research Diagnostic Criteria for Temporomandibular Disorders diagnosis of osteoarthritis were randomly assigned to 1 of 2 study groups receiving either low- or medium-molecular weight HA after arthrocentesis. The level of maximum pain at chewing was the primary outcome variable, and maximum pain at rest, subjective chewing efficiency, functional limitation, treatment tolerability, perceived treatment effectiveness, and jaw range-of-motion function in millimeters were the secondary outcomes. All variables were assessed and compared between groups at baseline, at the end of treatment, and 3 months later. Results: Forty subjects entered the study. At the end of the follow-up period, all the outcome variables improved in both groups of patients. A between-group comparison of changes over time showed that differences were not significant for any of the outcome variables, that is, pain at chewing (F = 0.056, P =.815), pain at rest (F = 0.383, P =.541), chewing efficiency (F = 0.050, P =.825), functional limitation (F = 0.268, P =.609), and mouth opening (F = 0.003, P =.954). In addition, no between-group differences were shown for perceived treatment effectiveness and treatment tolerability. Conclusions: Similar positive effectiveness was shown for 2 treatment protocols for TMJ osteoarthritis (ie, 5-session single-needle arthrocentesis plus low- or medium-molecular weight HA)
Mechanical device with five-arms tested on service
No full textWe present the stress analysis of a pouring concrete device. In order to test the prototype of a pouring concrete equipment composed of fivearms with hollow rectangular cross sections, an extensive study about equipment for pouring concrete has been undertaken. An upgrade of a four-arms device already existing and actually working would be developed. Tests have been performed both on the prototype of the equipment and on a virtual model of the device, performed by a 3D CAD modeler and analyzed through FEM numerical programs. During experimental tests, a laser device has measured deflections at the end of the fifth arm, corresponding to applied loads. For measuring strains in the critical points highlighted by the numerical simulation strain rosette have been employed. In both the static and the dynamic conditions, Mohr's circles have been drawn from the 3D strain state and the 2D plane stress experimental records and they have been compared with those predicted through the finite element analysis. From the comparison between numerical and experimental results, a very good correlation has been obtained for static loading to assess the soundness of the virtual model
Functional recovery after hip resurfacing and rehabilitation
No full textContext: Surface replacement of the hip is aimed especially at active patients, and it seems to achieve optimal functional results in a short time if associated with a tailored rehabilitation protocol. Objective: To assess the functional outcome in a group of active patients after hip resurfacing. Design: Clinical measurement and controlled laboratory study in a case series. Setting: Gait-analysis laboratory. Participants: 8 patients and a control group of 10 subjects. Interventions: Patients treated with Birmingham hip-resurfacing system and a tailored rehabilitation protocol Main Outcome Measures: Clinical assessment (Harris Hip Score [HHS]) and instrumented gait analysis including muscular electromyographic assessment. Patients were assessed preoperatively and at 3 and 9 mo follow-up after surgery. Results: HHS showed a significant increase from the baseline to 3- (P =.008) and 9-month (P =.014) follow-up; 5 patients returned to sport. Gait pattern in the presented case series of patients improved substantially 3 mo postoperatively, and minimal further changes were present 9 months postoperatively. Residual abnormalities of time-distance and hip-kinematics parameters were consistent with a slow gait. A complete restoration of the muscle-activation pattern during gait was achieved. Conclusion: Hip resurfacing associated with a rehabilitation protocol based on the characteristics of the implant provides excellent clinical and functional outcome, especially for very active patients
Virtual mechanical product disassembly sequences based on disassembly order graphs and time measurement units
No full textRecently, the approach that defines the total life cycle assessment (LCA) and the end of
life (EoL) in the early design phases is becoming even more promising. Literature evidences many
advantages in terms of the saving of costs and time and in the fluent organization of the whole
design process. Design for disassembly (DfD) offers the possibility of reducing the time and cost of
disassembling a product and accounts for the reusing of parts and of the dismantling of parts, joints,
and materials. The sequence of disassembly is the ordered way to extract parts from an assembly
and is a focal item in DfD because it can deeply influence times and operations. In this paper,
some disassembly sequences are evaluated, and among them, two methods for defining an optimal
sequence are provided and tested on a case study of a mechanical assembly. A further sequence of
disassembly is provided by the authors based on experience and personal knowledge. All three are
analyzed by the disassembly order graph (DOG) approach and compared. The operations evaluated
have been converted in time using time measurement units (TMUs). As result, the best sequence has
been highlighted in order to define a structured and efficient disassembly
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