1,720,987 research outputs found
Sterno clavicular joint dislocation: A case report of a surgical stabilization technique
No full textSterno Clavicular Joint (SCJ) dislocations are rare injuries of the shoulder girdle. Their management is controversial due to a not guaranteed outcome after any kind of treatment (conservative or open). Open reduction is challenging because of the anatomical site, while the conservative treatment does not always improve pain or instability discomfort. We report a case of traumatic and painful anterior SCJ dislocation of a young policewoman treated with open reduction by a new surgical technique. Functional result is extremely good at 2 years of follow-up. © 2010 Springer-Verlag
Custom Reconstruction Around the Knee
No full textWith rapid prototyping technique, an individual-based solution can be performed on the patient anatomy and his clinical needs.
Different products can be obtained starting from custom-made prostheses and specifc instruments. 3D printing allows to design an architecture with similar mechanical characteristic of bone [8], able to induce osteointegration and decrease the stress-shielding phenomenon due to the porosity and the elasticity of trabecular titanium [9]. Moreover, rapid prototyping can be used to
develop specifc instruments for each single step, minimizing the approach and bone loss, reducing the time of surgery and improving the reconstruction. The aim of our research is to develop a new customized implant for knee repair to treat wide
defects that alternatively may require commercial implants such as UKA, TKA, modular prostheses or massive allograft transplantation.
The idea is an hybrid prosthesis composed by a metallic frame with poly-caprolactone (PCL), a biodegradable material on the joint surface that be considered as a scaffold with similar mechanical characteristic of the implant itself in the short term, but potentially able to be substituted from the regenerative activity of the patient during time confguring a sort of biological prosthesis.
This procedure allows to preserve the most bone stock possible, respecting the stability given by soft tissue (ligaments) and maintaining the articular surface on the opposit
Computer Assisted Surgery and 3D Printing in Orthopaedic Oncology: A Lesson Learned by Cranio-Maxillo-Facial Surgery
Get PDFPrimary bone sarcomas are rare tumors and surgical resection in combination with chemo
and radiation therapy is the mainstay of treatment. Some specific anatomical sites still represent a
reconstructive challenge due to their complex three-dimensional anatomy. In recent years, patient
specific instruments along with 3D printing technology has come to represent innovative techniques
in orthopaedic oncology. We retrospectively reviewed 23 patients affected by primary bone sarcoma
treated with patient-specific instruments and 3D printing custom made prostheses. At follow up
after approximately two years, the infection rate was 26%, mechanical complication rate 13%, and
local recurrence rate 13% (with a five-years implant survival rate of 74%). Based on our experience,
patient-specific instruments and 3D custom-made prostheses represents a reliable and safe technique
for improving the accuracy of resection of primary bone tumour, with a particular use in pelvic
surgery ameliorating functional resul
CIC rearranged sarcomas: A single institution experience of the potential pitfalls in interpreting CIC FISH results
No full textAim: The aim of this study was to establish how reliable FISH CIC analysis using an IVD (in vitro diagnostic)
commercial probe is.
Methods and results: A series of 19 CIC-DUX4 sarcomas were evaluated. The samples presenting CIC-DUX4 fusion
transcript detected by Reverse Transcription-Polymerase Chain Reaction (RT-PCR) and Sanger sequencing and/
or Next Generation Sequencing were selected for Fluorescent in Situ Hybridization (FISH) CIC analysis with CIC
break-apart IVD probe and compared to molecular analysis. CIC FISH analysis showed 26% of false negatives.
Conclusion: Our results indicate that, in the setting of CIC-DUX4 fusion positive small round cell sarcomas, CIC
FISH using IVD commercial probe may lead to false-negative results. This novel study evaluates the diagnostic
use of a commercial IVD CIC probe for FIS
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Minimally invasive treatment of long bone non-unions with bone marrow concentrate, demineralized bone matrix and platelet-rich fibrin in 38 patients
No full textTo determine the efficacy of percutaneous injection of autologous bone marrow concentrated (BMC), demineralized bone matrix (DBM), and platelet rich fibrin (PRF) in the treatment of long bone non-unions. From January 2011 to January 2018 patients with non-union of the lower limbs who were on the waiting list for open grafting with established tibial or femoral non-union and minimal deformity were eligible to participate in this study. Patients were treated with a single percutaneous injection of DBM, BMC and PRF. Our study group comprised 38 patients (26 males and 12 females; mean age 39, range 18 to 65). Non-unions were located in the femur (18 cases) and in the tibia (20 cases). Clinical and imaging follow-up ranged from 4 to 60 months (mean 20 months). Bone union occurred in 30 out of 38 patients (79%) in an average of 7 months (range 3 to 12) and all healed patients had full weight bearing after 9 months on average (range 6 to 12) from injection. In 19 cases the osteosynthesis was removed 12 months on average (range 3 to 36) from surgery. One patient developed infection at the non-union site after treatment. Percutaneous injection of DBM, BMC, and PRF is an effective treatment for long-bone non-unions. This technique allows the bone to heal with a minimally invasive approach and with a hospitalization of 2 days. Key elements of bone regeneration consist of a combination of biological and biomechanical therapeutic approach
Usefulness of β-catenin expression in the differential diagnosis of osteosarcoma, osteoblastoma, and chondroblastoma
No full textThe aim of this study is to assess the usefulness of beta-catenin immunohistochemical expression in the differential diagnosis of osteoid-producing primary tumors of bone. Seventy cases of osteoid-producing tumors of bone (24 conventional osteosarcomas, 18 osteoblastomas, 13 osteoblastoma-like osteosarcomas, 10 chondroblastomas, and 5 chondroblastoma-like osteosarcomas) diagnosed at Istituto Ortopedico Rizzoli were reviewed and evaluated for the intensity, extension, and subcellular distribution of immunohistochemical expression of beta-catenin. A majority of cases (73%, 51 cases) exhibited cytoplasmic and/or membranous positivity in varied degrees of intensity and proportion of positive cells, in the absence of nuclear staining. Fifteen cases (21%) were completely negative, including two osteoblastomas, five chondroblastomas, three conventional osteosarcomas, four osteoblastoma-like osteosarcomas, and one chondroblastoma-like osteosarcoma. A minority of cases (6%) including three osteoblastoma-like osteosarcomas and one osteoblastoma showed focal nuclear beta-catenin positivity with or without concomitant cytoplasmic staining. In the current series, beta-catenin showed not to be useful in the differential diagnosis of osteoid-producing primary bone tumors
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