1,721,002 research outputs found
Il ruolo del dexibuprofene nel trattamento del dolore osteoarticolare: aspetti farmacologici e clinici. [The role of dexibuprofen in the treatment of osteoarthritis:pharmacological and clinical aspects]
No full textAn epidemiological survey conducted in several European countries has shown that in the adult
population the musculoskeletal system is by far the most common location of pain, whether it is due
to traumatic events or chronic diseases. The presence of this disorder often results in a significant
disability, with partial or complete impairment of simple daily activities such as sleeping, working or
driving. Osteoarthritis has specific peculiarities depending on the affected anatomical district, but
it is generally a chronic degenerative disease in which recurring episodes of inflammation overlap,
which are the cause of acute painful accesses and represent an additional injurious mechanism for
the joint. In these phases the administration of NSAIDs is essential. Some NSAIDs, particularly those
belonging to the family of arylpropionic acids such as ibuprofen, are used in a racemic form, i.e. as
a mixture of the two enantiomers R(-)- and S(+)-, although numerous pharmacological studies have
shown that most, if not all, the pharmacological properties reside in only one of the two enantiomers.
This is the case of dexibuprofen, the S(+)- enantiomer of ibuprofen. In this article we will describe
the pharmacological characteristics of dexibuprofen and the advantages of its therapeutic use in
osteoarthritis pain
Distribution of nicotinic receptors in cynomolgus monkey brain and ganglia: localization of α3 subunit mRNA, α-bungarotoxin and nicotine binding sites
No full textPharmacology of pain
Full text linkThis article discusses the mechanisms of action of the main drugs used to treat pain, in particular inflammatory pain. The drugs are described following a classification based on the steps of pain processing that they primarily affect
RANS-Based Aerothermal Database of LS89 Transonic Turbine Cascade Under Adiabatic and Cooled Wall Conditions
No full textModern gas turbines for aeroengines operate at ever-increasing inlet temperatures to maximize thermal efficiency, power, output and thrust, subjecting turbine blades to severe thermal and mechanical stresses. To ensure component durability, effective cooling strategies are indispensable, yet they strongly influence the underlying aerothermal behavior, particularly in transonic regimes where shock–boundary layer interactions are critical. In this work, a comprehensive Reynolds-Averaged Navier–Stokes (RANS) investigation is carried out on the LS89 transonic turbine cascade, considering both adiabatic and cooled wall conditions. Three operating cases, spanning progressively higher outlet Mach numbers (0.84, 0.875, and 1.020), are analyzed using multiple turbulence closures. To mitigate the well-known model dependence of RANS predictions, a model-averaging strategy is introduced, providing a more robust prediction framework and reducing the uncertainty associated with single-model results. A systematic mesh convergence study is also performed to ensure grid-independent solutions. The results show that while wall pressure and isentropic Mach number remain largely unaffected by wall cooling, viscous near-wall quantities and wake characteristics exhibit a pronounced sensitivity to the wall-to-recovery temperature ratio. To support further research and model benchmarking, the complete RANS database generated in this work is released as an open-source resource and made publicly
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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