23 research outputs found
Attività di formazione, ricerca e restauro nel Parco delle Tombe della Via Latina
No full textThis intervention starts from the moment of the discovery of the funerary monuments of
exceptional interest, not only archaeological, discovered at the third mile of the Via Latina in 1857 and immediately subject to interventions by the competent authorities of the time. Starting from the oleographic reconstruction of the elevation of the tomb of the Valeri, inspired by the dictates of Viollet le Duc by the architect Francesco Fontana, after a period of quiescence of about 150 years, the research and restoration activity was resumed on the occasion of the funding for the Jubilee of 2000 with the opening of various restoration building sites (t. Pancrazi and Valeri) , recovery and anastylosis of the columns of the basilica of S. Stefano and archaeological excavations of investigation. The gigantic construction site area that occupies about half of the park, after a 10-year stop, was completed, reopened to the public and integrated with the opening of the Barberini tomb. The opening to the public has made it possible to resume the involvement of students and private individuals in the study, research and enhancement of the monuments present with various design hypotheses and tutoring with universities
La basilica di San Sebastiano fuori le mura a Roma: interventi di miglioramento statico sulle coperture del deambulatorio.
No full textThe basilica of San Sebastiano, a cemetery and is located on the fourth mile of the ancient Via Appia, it was built at the behest of Emperor Constantine in the 4th century AD. in honor of the Apostles Peter and Paul. At the beginning of the 4th century, in the catacombs below, San Sebastiano, martyr-soldier at the time of Diocletian, was buried and the basilica was later dedicated to him. The façade is punctuated by the paired Ionic columns of the portico, with three arches, which correspond to the pilasters of the upper order.
The Constantinian basilica was built imitating the models of circuses, with a central
nave and a horseshoe-shaped path around it. It was preceded by a large quadrangular
atrium. In 1608 Cardinal Scipione Borghese undertook a complete remodeling
of the basilica and crypt of San Sebastiano based on a design by Flaminio Ponzo.
The restoration was completed by Giovanni Vasanzio while the façade dated 1612
is designed by Flaminio Ponzo. The new building occupies the ancient central nave
and boasts a carved wooden ceiling: it depicts the titular saint and the coats of arms
of Cardinal Scipione Borghese and Pope Gregory XVI.
At the end of the central nave there is the main altar designed by Flaminio Ponzio;
above there is a canvas “The Crucifi xion” by Innocenzo Tacconi and on the sides
the busts of Saints Peter and Paul by Nicolas Cordier.
The attention of the intervention carried out by the staff of the Appia Archaeological
Park with funds from the FEC focuses on the restoration of the roofs and on the
safety measures relating to the crack pattern established after the 2016 earthquake.
The intervention on the roof concerns the restoration of 3 half trusses, which
had been recently made with poor quality material. The cracked trusses have been
removed and replaced with similar structures in chestnut wood; the model of the
trusses was based on late antique models. The design reference was that of the roof
of S.Maria della Quercia, where the models of the Massenzian-Constantinian basilicas
were perpetuated. The cracked apse was only secured with structural mesh and
monitored with glass double beams
The Restoration of Palazzo De Caro in Cetraro
No full textIl Palazzo De Caro quale elemento identitario di una comunità è posto alle porte del centro storico di Cetraro (CS) ed è collocato in una posizione privilegiata da cui è possibile osservare la costa dell’alto tirreno cosentino. Il Palazzo risalente al 1860, realizzato su commissione di don Lodovico De Caro che acquistò i terreni per “la somma di ducati 1.300”, mostra i segni del tempo con la tangibile testimonianza storica con un peculiare ossimoro, tipico dei palazzi ottocenteschi, tra piani inferiori, tipici dell’architettura rurale con il vecchio frantoio, e piani superiori, nobili e, rigidamente separati dalla servitù, collegati in un percorso che esalta salotti, statue d’epoca, tendaggi, ritratti di famiglia. Le peculiarità e i valori testimoniali impongono la salvaguardia del palazzo anche per l’avvio di un processo che deve interessare l’intero centro storico, oggi tanto abbandonato quanto ricco di storia, arte, architettura e bellezza.The building object of this study is located at the entrance of the historical center of Cetraro (CS), a village facing the Tyrrhenian sea in a privileged position on the Calabrian coast. Built in 1860 on behalf of don Ludovico De Caro the palace occupies lands that were bought for “ducati 1300” by the rich nobleman, and appears today to have absorbed the marks of time. Entering the ancient gates, history shows the particular oxymoron typical of the nineteenth-century buildings: the lower floors, typically rural with the old olive-press, and the upper floors, noble and primly divided by the servants’ rooms, connected in a path that highlights the lounges and living rooms with their sculptures, curtains, family portraits that narrate histories and legends. In this context, my choice as a restorer has been not to distort the spirit of time and places and their historical authenticity, respect the ancient mansion as it unveils itself to the habitual visitor. This operation doesn’t only aim to rehabilitate an ancient mansion, but, throught it, to retrain an entire historical centre, nowadays as abandoned as rich of history, art, architecture and beauty. The restoration of the buildings intents to be the beginning of a more structured project for a “Scattered Hotel”, whose benefits and responsibilities are shared by all the citizenry. The proposal for the project therefore considers the centrality of the functions inside Palazzo De Caro (restaurant, hall, reception) to be at service of a wide network of scattered guest houses in the historical centre connected by paths though squares, alleys and picturesque views
[Hyponatremia and syndrome of inappropriate ADH secretion (SIADH)] [Iponatriemia e sindrome da inappropriata secrezione di ormone antidiuretico (SIADH)]
No full textThe syndrome of inappropriate ADH secretion (SIADH), also termed ''syndrome of inappropriate antidiuresis (SIAD)'', is an often unrecognized cause of hypotonic hyponatremia, arising from ectopic release of ADH in lung cancer or as a side effect of various drugs. In SIADH, hyponatremia results from selectively impaired water excretion by the kidney, whereas the external Na+ balance is normally regulated. Despite the increase in total body water, only a slight reduction of urine output and modest edema are usually seen. Renal function and acid-base balance are generally preserved, while subclinical neurological impairment may occasionally become life-threatening, when hyponatremia has an abrupt onset. The major clinical variants of SIADH are reviewed here, with particular emphasis on causes, iatrogenic complications and hospital-acquired hyponatremia. Effective treatment of SIADH is based on water restriction, hypertonic saline plus loop diuretics, or aquaretics. Worsening of hyponatremia may result from parenteral isotonic fluid administration, emphasizing the importance of an early diagnosis and careful follow-up of these patients
Progetto e restauro e apertura di una strada lungo le Mura Aureliane a Roma in uno studio del Valadier (1806)
No full text
Renal function improvement evaluated by cystatin-C serum levels in patients with systemic AL amyloidosis treated with MEL-DEX association
No full textCorrection to: Vitamin D protects endothelial cells from irradiation-induced senescence and apoptosis by modulating MAPK/SirT1 axis
No full text: Unfortunately, the 5th author name has been publisehd incorrectly in the original publication. The complete correct name is given below
Correction to: Histone deacetylase inhibitor ITF2357 (givinostat) reverts transformed phenotype and counteracts stemness in in vitro and in vivo models of human glioblastoma (Journal of Cancer Research and Clinical Oncology, (2019), 145, 2, (393-409), 10.1007/s00432-018-2800-8)
No full textIn the original publication, the 6th author’s first name and the last name was inverted and incorrectly published. The correct author name is Letizia Ferella
Study of Docosahexaenoic acid non-enzymatic oxidation products as biomarkers for neurodegenerative diseases
No full textOs n-3 e n-6 são duas famílias de ácidos graxos poli-insaturados. Os ácidos graxos de cadeia longa como o ácido araquidônico (AA) e docosahexaenoico (DHA) apresentam importantes funções no desenvolvimento e funcionamento do cérebro. Os produtos de oxidação dos ácidos graxos poli-insaturados estão presentes ou aumentados ao longo do desenvolvimento de doenças neurodegenerativas. A caracterização de tais produtos é crítica para o estudo que busca entender o seu papel fisiopatológico no desenvolvimento de tais doenças. No presente trabalho, buscou-se o desenvolvimento de uma ferramenta analítica sensível e específica para a detecção e quantificação dos hidroperóxidos e hidróxidos do AA (HpETE e HETE), do seu precursor, o ácido linoleico (HpODE e HODE) e do DHA (HpDoHE e HDoHE). Estes hidroperóxidos foram sintetizados por fotooxidação e os hidróxidos correspondentes foram obtidos através da redução com o NaBH4. Os isômeros isolados foram caracterizados por LC-MS/MS. Os íons produto específicos de cada isômero foram escolhidos para a construção do método de monitoramento de reação selecionada (selected reaction monitoring - SRM) para a realização da análise quantitativa dos analitos de interesse. Cabe salientar que os dados obtidos poderão ser utilizados em bibliotecas de análise lipidômica e oxi-lipidômica pois serão essenciais para a identificação e quantificação dos analítos de interesse do presente estudo em diversas doenças. Utilizando o método padronizado, buscamos investigar o papel dos hidroperóxidos e hidróxidos do DHA, LA e AA em um modelo animal para a esclerose lateral amiotrófica (ELA), uma doença neurodegenerativa que acomete neurônios motores. Foi observado um aumento nos níveis de 13-HpODE, 9-HpODE e 12-HETE no córtex motor dos animais avaliados. Adicionalmente, foram observadas alterações nas taxas lipólica e lipogênica no tecido adiposo para os animais ELA em relação aos respectivos controles. Em conjunto, os dados apresentados no presente trabalho corroboram com os trabalhos da literatura que associam alteração dos níveis dos produtos de oxidação dos ácidos graxos poli-insaturados em doenças neurodegenerativas e o metabolismo energético alterado em ELA. Futuramente é necessária uma investigação mais ampla dos níveis dos hidroperóxidos e hidróxidos lipídicos em diferentes tecidos e do metabolismo lipídico, e os conhecimentos gerados poderão ser uma importante fonte de novas opções terapêuticas para os pacientes portadores de ELA.The n-3 and n-6 are two olyunsaturated fatty acids families. The long chain fatty acids such as arachidonic (AA) and docosahexaenoic acid (DHA) have important roles in the development and function of the brain. Polyunsaturated fatty acids (PUFAs) oxidation products are present or increased during the progression of neurodegenerative diseases. The characterization of DHA oxidation products is critical to understand their roles in the development of such diseases. In the present study, we sought to develop a sensitive and specific analytical tool for the detection and quantification of AA hydroperoxides and hydroxides (HPETE and HETE), its precursor linoleic acid (HPODE and HODE) and DHA (HpDoHE and HDoHE). These hydroperoxides were synthesized by photooxidation and the corresponding hydroxides were obtained by reduction with NaBH4. The isolated isomers were characterized by LC-MS/MS, and unique and specific fragment ions were chosen to construct a selected reaction monitoring (SRM) method for the targeted quantitative analysis. It should be emphasized that the data obtained - in the form of lipidomics and oxy-lipidomics libraries - may be used to assist in several diseases. Using the standardized method, we investigated the role of hydroperoxides and hydroxides of DHA, LA and AA in an animal model of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease that affects motor neurons. Increased levels of 13-HPODE, 9-HPODE and 12-HETE were observed in the animals motor cortex. Additionally, results show changes in lipogenic and lipolytic rates in adipose tissue for ALS animals when compared to their respective controls. Altogether, the data presented herein corroborate with the literature by linking altered levels of PUFAs oxidation products in neurodegenerative diseases with altered energetic metabolism in ALS. In the future, a more extensive investigation of the hydroperoxide and hydroxide level in different tissues as well as the lipid metabolism must be done, which could lead to new therapeutic options for ALS patient
