1,721,727 research outputs found
Un'analisi di alcuni fenomeni idrologici a scala di bacino mediante l'uso del concetto di entropia
No full textControlled Release and Antibacterial Properties of Quercetin-Loaded Silica Hybrids for Drug Delivery
No full textNatural products from plants are valuable alternatives to synthetic drugs for treating cancers and bacterial infections. However, their low solubility and absorption pose challenges, necessitating a biocompatible system for controlled release at the target site. Hybrid materials, such as silica (SiO2) encapsulating quercetin (Qu), offer a solution by protecting the organic compound and maintaining its anticancer and antibacterial properties. Two synthesis methods for quercetin-encapsulated silica were explored: one with an acid catalyst (SiO2-HNO3+Qu5%) and one without a catalyst (SiO2+Qu5%), aiming for an eco-friendly approach. The encapsulation efficiency of the silica matrix was analyzed, and release studies were carried out using UV–visible spectroscopy under physiological (pH = 7.4) and cancer (pH = 5.0) conditions. The release of quercetin was found to be pH-dependent, with the SiO2+Qu5% system demonstrating superior release capacity. However, the system synthesized with the acid catalyst exhibited better antibacterial activity, likely due to the release of nitrate ions. The study highlights the potential of these hybrid materials in drug delivery applications, balancing efficient quercetin release, and enhanced antibacterial effects
Analisi della distribuzione delle caratteristiche idrologiche dei suoli per applicazioni di modelli di simulazione afflussi-deflussi.
No full textImproving translation from preclinical studies to clinical trials in acute kidney injury
No full textBackground: Several cellular and molecular targets and mechanisms have been investigated in preclinical studies of acute kidney injury (AKI), but translation in successful clinical studies has failed to date. This article reviews many issues that have limited this and the potential future perspectives in AKI prevention and treatment. Summary: Preclinical models of AKI should closely mimic the complexity of human AKI, considering the importance of several comorbidities in determining the clinical course and outcomes in the human disease. Moreover, studies should test novel interventions in models where AKI is already established, instead of focusing only at primary prevention. AKI definitions and endpoints in animal studies should be similar to those applied in clinical studies; in particular, AKI biomarkers should be implemented to guide patient selection for clinical trials and monitor intervention efficacy. In this scenario, cell-cycle arrest biomarkers have been widely investigated as AKI predictors in both preclinical and clinical studies and they serve as useful tools for future interventional studies. A better understanding of human AKI through a large collection of biological samples and kidney biopsies and omics applications, and an iterative relationship between preclinical and clinical studies are critical steps to improve future preclinical models and clinical trials. Finally, given the great variability in clinical manifestation of AKI, a strong collaboration between research centers and industry is recommended. Key messages: Several methodological issues have hampered the translation of basic research findings in clinical studies, and overcoming these obstacles is necessary to achieve success
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Distribuzione della NADPH-diaforasi nel SNC di alcune specie di ilidi (Hylidae, Anura, Amphibia)
No full text- …
