274 research outputs found
Sulle arti. Carducci e i salotti letterari di fine Ottocento
No full textSi intende qui analizzare il rapporto tra Carducci e alcuni tra i principali salotti letterari dell'epoca, a partire dalle più recenti letture critiche carducciane e tramite l’avvio di un’ampia indagine che dall’epistolario giunge alla definizione di alcuni rapporti-chiave tra Otto e Novecento. La ricostruzione di tali relazioni – si ricordano qui alcuni dei salotti letterari frequentati da Carducci tra cui quello di Louise Grace Bartolini o quello di Ersilia Caetani Lovatelli – mette in luce ampie riflessioni sull’arte condivise da Carducci con altri intellettuali dell’epoca. Tale percorso critico permette dunque di delineare una costellazione di figure e di influenze, in grado di restituire la complessa rete nella quale si muovono, nella seconda metà dell’Ottocento, artisti, letterati e intellettuali, di grande importanza anche alla luce dei successivi scenari novecenteschi
TMS-induced virtual lesion of the Frontal Eye Field (FEF) interferes with reflexive shifts of attention triggered by averted gaze
No full textNeurocognitive and neuroimaging outcome of early treated young adult PKU patients: A longitudinal study
No full textThe aim of the study was to explore the outcome of neurocognitive deficits and neuroimaging correlates in young adult early treated phenylketonuric (PKU) patients. We conducted a longitudinal study of 14 PKU patients that were assessed for IQ and neuropsychological functioning including executive functions (EF) over 14years of follow-up (age range at 1st and 2nd assessments were 7.8-13.5 and 22.2-27.7years, respectively). The IQ of all 14 PKU patients was within the normal range. With respect to the 1st assessment, mean IQ at follow-up did not decrease significantly. Compared to control subjects (n=14), mean IQ of patients was significantly lower (p=.0005). Throughout adolescence and early adulthood there was an improvement of neuropsychological functioning of PKU patients in spite of the relaxation of diet, however some deficits were still detectable when compared to controls. All patients that underwent a second MRI scan showed white matter alterations ranging from mild to severe which was correlated neither with IQ nor with EF scoring. Cognitive, neuropsychological and neuroimaging outcome was influenced from life-long and/or second decade of life metabolic control. Nevertheless patients' developmental trajectories were in some cases independent from metabolic control. Our results support the hypothesis of an individual vulnerability to phenylalanine. However, as long as individual factors that account for the vulnerability to Phe are not recognized, strict dietary control is recommended for all the patients also in the second decade of life
Psychiatric disorders in adolescent and young adult patients with phenylketonuria
No full textBackground and objectives: Psychiatric symptoms are a challenging aspect in adolescent and adult early treated phenylketonuric (ETPKU) patients. To assess the occurrence of psychiatric disorders we explored the presence of symptoms requiring intervention and further investigated the link between psychiatric disorders, the quality of biochemical control and cognitive functioning.
Patients and methods: Forty-six ETPKU patients (aged 12 to 44) and 30 age-matched healthy controls were sub- jected to cognitive and psychiatric assessment by means of self-report questionnaires and psychiatric interview. Psychiatric diagnoses, if detected, were made according to DSM-5 criteria. Concomitant IQ, historical and concur- rent biochemical metabolic controls were included in the statistical analysis.
Results: Twenty-five out of 46 ETPKUs showed clinical scores on at least one scale of the psychiatric assessment (7/30 in controls); anxiety and withdrawal were the most frequent self-reported symptoms. Seventeen patients (and no controls) met criteria for a psychiatric diagnosis, most of them belonging to the Anxiety Disorders cate- gory. The occurrence of psychiatric symptoms was not associated with the life-long and concurrent quality of metabolic control but patients with good metabolic control (≤ 500 μM) in the first 11 years of life showed higher frequency of psychiatric diagnosis (Fisher's exact p = .0300).
Discussion/conclusion: ETPKUs show a higher than normal vulnerability to psychiatric disorders, which cannot be explained by the usual biochemical alterations influencing intellectual outcome. Our data support the hypothesis that the burden of the disease acts as psychological stress for children and their families. Possible involvement of neuromediators in the pathogenesis of these complex symptoms requires further investigation
Un magistero contrastato: Carducci e il socialismo
No full textIl saggio analizza il complesso rapporto che legò Carducci ai padri del socialismo italiano, con particolare riferimento ad Andrea Costa, Filippo Turati e Leonida Bissolati, tutti suoi allievi all\u27Ateneo bolognese. Si prendono in esame le posizioni pubbliche e private di Carducci sul nuovo movimento politico, dall\u27iniziale ma sempre cauta simpatia alla progressiva e sempre più drastica chiusura, testimoniata da numerosi scritti polemici in prosa e in versi. Si esamina altresì la ricezione di Carducci nella galassia socialista, improntata a un sostanziale apprezzamento, nonostante alcuni momenti di crisi (la pubblicazione del Canto dell\u27amore, la "conversione" monarchica del 1878, la polemica con Rapisardi, l\u27appoggio convinto a Francesco Crispi, l\u27ode La guerra). Tale vicinanza è confermata dalle numerose commemorazioni che esponenti del movimento hanno pronunciato alla morte dello scrittore e dagli articoli pubblicati sull\u27"Avanti!" nei primi anni del XX secolo, prima che lo scoppio della Grande Guerra e l\u27urgenza di nuove e più drammatiche questioni relegassero lo scrittore maremmano in un passato avvertito come sempre più distante
Improved realistic Laplacian estimate of highly-sampled EEG potentials by regularization techniques
No full textIn this study we investigated the effects of λ correction, generalized cross-validation (GCV), and Tikhonov regularization techniques on the realistic Laplacian (RL) estimate of highly-sampled (128 channels) simulated and actual EEG potential distributions. The simulated EEG potential distributions were mathematically generated over a 3-shell spherical head model (analytic potential distributions). Noise was added to the analytic potential distributions to mimic EEG noise. The magnitude of the noise was 20, 40 and 80% that of the analytic potential distributions. Performance of the regularization techniques was evaluated by computing the root mean square error (RMSE) between regularized RL estimates and analytic surface Laplacian solutions. The actual EEG data were human movement-related and short-latency somatosensory-evoked potentials. The RL of these potentials was estimated over a realistically-shaped, magnetic resonance-constructed model of the subject's scalp surface. The RL estimate of the simulated potential distributions was improved with all the regularization techniques. However, the λ correction and Tikhonov regularization techniques provided more precise Laplacian solutions than the GCV computation (P < 0.05); they also improved better than the GCV computation the spatial detail of the movement- related and short-latency somatosensory-evoked potential distributions. For both simulated and actual EEG potential distributions the Tikhonov and λ correction techniques provided nearly equal Laplacian solutions, but the former offered the advantage that no preliminary simulation was required to regularize the RL estimate of the actual EEG data
Un metodo efficiente basato su Matlab per la progettazione di amplificatori in transimpedenza risonanti ad elevato guadagno
No full textTranscranial Magnetic Stimulation over Frontal Eye Field interferes with reflexive shifts of attention induced by averted gaze.
No full textA MATLAB-based Method for Designing High-Gain Resonant Transimpedance Amplifiers
No full textIn this paper, we propose a novel efficient method for the design of high-gain resonant transimpedance amplifiers (TIAs) usingMATLAB. The procedure provides the designer with an effective tool, useful to explore the effects of different device parameter combinations in complex network topologies used in several application fields. We applied this method to improve the detection capability of a previously designed chlorophyll-A (Chl-A) sensor, in order to in-vivo assess the seawater quality. By exploiting the interesting bandpass behavior exhibited by a T feedback network, we were able to redesign the resonant TIA stage of a low-cost lock-in amplifier working at 1 kHz, easily increasing the gain by a factor of 100, and reaching an overall gain of 216 dB while reducing the detectivity to almost 500 fA. Moreover, the proposed analysis provides the optimal circuit parameter values for a wide working frequency range without further numerical optimization, giving an interesting perspective of its potential use in those telecommunication applications where high sensitivity is required
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