41 research outputs found
Differential expression of connective tissue growth factor in inflammatory bowel disease.
No full textSimulation of the dynamics of an olympic rowing boat
No full textEditors: P. Wesseling, E. Oñate, J. Périau
Reshaping Organizations with Social Networks and Collaboration
No full textThe digital revolution is impacting many aspects of the society. Collaboration tools are challenging the traditional hierarchical model thanks to pervasive computing and always connected devices. Organizations are transforming to take advantage and to adapt to this new paradigm. When creativity and innovation are critical to the success of a company, flattened hierarchies and decentralized cooperation can leverage human talent better. With this paper the author aims to provide a literature review to highlight the historical and philosophical deployment of the different approaches to the relationship between ICT and Organization Design. This is the first step of a research project aiming at proposing emergent new organization design approach
Modeling interactions between Human Equilibrative Nucleoside Transporter-1 and other factors involved in the response to gemcitabine treatment to predict clinical outcomes in pancreatic ductal adenocarcinoma patients
No full textBackground: Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy, characterized by largely unsatisfactory responses to the currently available therapeutic strategies. In this study we evaluated the expression of genes involved in gemcitabine uptake in a selected cohort of patients with PDAC, with well-defined clinical-pathological features. Methods: mRNA levels of hENT1, CHOP, MRP1 and DCK were evaluated by means of qRT-PCR in matched pairs of tumor and adjacent normal tissue samples collected from PDAC patients treated with gemcitabine after surgical tumor resection. To detect possible interaction between gene expression levels and to identify subgroups of patients at different mortality/progression risk, the RECursive Partitioning and Amalgamation (RECPAM) method was used. Results: RECPAM analysis showed that DCK and CHOP were most relevant variables for the identification of patients with different mortality risk, while hENT1 and CHOP were able to identify subgroups of patients with different disease progression risk. Conclusion: hENT1, CHOP, MRP1 and DCK appear correlated to PDAC, and this interaction might influence disease behavior
Modeling interactions between Human Equilibrative Nucleoside Transporter-1 and other factors involved in the response to gemcitabine treatment to predict clinical outcomes in pancreatic ductal adenocarcinoma patients
No full textBackgroundPancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy, characterized by largely unsatisfactory responses to the currently available therapeutic strategies. In this study we evaluated the expression of genes involved in gemcitabine uptake in a selected cohort of patients with PDAC, with well-defined clinical-pathological features.MethodsmRNA levels of hENT1, CHOP, MRP1 and DCK were evaluated by means of qRT-PCR in matched pairs of tumor and adjacent normal tissue samples collected from PDAC patients treated with gemcitabine after surgical tumor resection. To detect possible interaction between gene expression levels and to identify subgroups of patients at different mortality/progression risk, the RECursive Partitioning and Amalgamation (RECPAM) method was used.ResultsRECPAM analysis showed that DCK and CHOP were most relevant variables for the identification of patients with different mortality risk, while hENT1 and CHOP were able to identify subgroups of patients with different disease progression risk. Conclusion: hENT1, CHOP, MRP1 and DCK appear correlated to PDAC, and this interaction might influence disease behavior
The role of aquaporin-4 in the blood-brain barrier development and integrity: Studies in animal and cell culture models
No full textAquaporin-4 (AQP4) is the major water channel expressed in brain perivascular astrocyte processes. Although the role of AQP4 in brain edema has been extensively investigated, little information exists regarding its functional role at the blood-brain barrier (BBB). The purpose of this work is to integrate previous and recent data regarding AQP4 expression during BBB formation and depending on BBB integrity, using several experimental models. Results from studies on the chick optic tectum, a well-established model of BBB development, and the effect of lipopolysaccharide on the BBB integrity and on perivascular AQP4 expression have been analyzed and discussed. Moreover, data on the BBB structure and AQP4 expression in murine models of Duchenne muscular dystrophy are reviewed. In particular, published results obtained from mdX(3cv) mice have been analyzed together with new data obtained from mdx mice in which all the dystrophin isoforms including DP71 are strongly reduced. Finally, the role of the endothelial component on AQP4 cellular expression and distribution has been investigated using rat primary astrocytes and brain capillary endothelial cell co-cultures as an in vitro model of BBB. (C) 2004 IBRO. Published by Elsevier Ltd. All rights reserved.
Accession Number: WOS:000225726000008
Document Type: Article
Language: English
Author Keywords: aquaporins; brain edema; co-cultures; astrocytes; mdx; muscular dystrophy
KeyWords Plus: DYSTROPHIC MDX-MICE; INSENSITIVE WATER CHANNEL; MIDDLE-T ONCOGENE; RAT-BRAIN; CHICK-EMBRYO; GLIAL-CELLS; PERIVASCULAR ASTROCYTES; MUSCULAR-DYSTROPHY; ORTHOGONAL ARRAYS; PLASMA-MEMBRANES
Reprint Address: Friger, A (reprint author), Univ Bari, Dept Gen & Environm Physiol, Via Amendola 165-A, I-70126 Bari, Italy
Addresses
The Great Theatre of the World. Salvator Rosa and the Academies
No full textLa mostra organizzata con Dulwich Picture Gallery di Londra e Kimbell Art Museum di Fort Worth dall’autrice con Helen Langdon e Xavier Salomon, presenta un ingente numero di capolavori di Salvator Rosa. Nel catalogo la studiosa ha redatto numerose schede e un saggio sul rapporto fondamentale dell’artista con il mondo accademico –letterario, teatrale ed artistico- del suo tempo. Attraverso documenti per lo più inediti (componimenti, lettere, inventari), l’autrice ricostruisce un pezzo di vita culturale e artistica tra Firenze e Roma a cavallo del quinto e settimo decennio del Seicento. Si tratta di uno scenario in cui, insieme al protagonista Rosa, si intrecciano artisti del calibro di Pier Francesco Mola e Carlo Dolci, e committenti quali Flavio Chigi o Giovan Carlo de Medici. The exhibition, organized with the Dulwich Picture Gallery in London and the Kimbell Art Museum in Fort Worth by the author toghether with Helen Langdon and Xavier Salomon, had shown many of the Salvator Rosa’s masterpieces. In the catalogue the scholar did many entries and an essay on the really essential relation among the artist and the Seventeenth Century Academies of Florence and Rome. Academies that were not only artistic but also of music, theatre and poetry. Thanks to unpublished documents (poems, letters and inventories) the author can reconstruct the artistic and cultural life in Florence and Rome between 1640th and 1650th. Together with Salvator Rosa are others leading artists and patrons such as Pier Francesco Mola, Carlo Dolci, Pietro da Cortona, and Flavio Chigi or Giovan Carlo de Medici.
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Expression of the Antiapoptotic Protein BAG3 Is a Feature of Pancreatic Adenocarcinoma and Its Overexpression Is Associated With Poorer Survival. Turco MC: Corresponding Author
No full textPancreatic ductal adenocarcinoma (PDAC) is one of the most deadly cancers, being the fourth leading cause of cancer-related deaths. Long-term survival reaching 15% is achieved in less than 5% of patients who undergo surgery, and median survival is only 6 months in those with inoperable lesions. A deeper understanding of PDAC biologic characteristics as well as novel prognostic markers are therefore required to improve outcomes. Herein we report that BAG3, a protein with recognized anti-apoptotic activity, was expressed in 346 PDACs analyzed, but was not expressed in the surrounding nonneoplastic tissue. In a cohort of 66 patients who underwent radical resection (R0), survival was significantly shorter in patients with high BAG3 expression (median, 12 months) than in those with low BAG3 expression (median, 23 months) (P = 0.001). Furthermore, we report that BAG3 expression in PDAC-derived cell lines protects from apoptosis and confers resistance to gemcitabine, offering a partial explanation for the survival data. Our results indicate that BAG3 has a relevant role in PDAC biology, and suggest that BAG3 expression level might be a potential marker for prediction of patient outcom
