1,721,111 research outputs found

    Hamartomas of the alimentary tract in dogs: A case series

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    Hamartomas are benign proliferations of disorganized tissues normally present in a given site. This study aimed to characterize histopathological features of alimentary tract hamartomas in dogs, focusing on their classification and diagnostic methods. Samples collected from 2 veterinary archives were evaluated using hematoxylin and eosin (HE), Masson’s trichrome (MT), Gomori, and Luxol fast blue stains. Immunohistochemistry was performed for α-smooth muscle actin (SMA), neurofilament, GFAP, neuron-specific enolase, von Willebrand factor, and c-kit. Sixteen hamartomas were identified: 6 neuromuscular and vascular hamartomas, 9 neurovascular hamartomas, and 1 vascular hamartoma. Locations included the oral cavity (6/16) and the gastrointestinal tract (10/16). Most dogs were mixed breeds (8/16) with a median age of 10.5 years. These findings suggest that hamartomas should be included in the differential diagnosis of oral and gastrointestinal masses in dogs. For accurate classification and diagnosis, MT in combination with α-SMA and neurofilament immunohistochemistry is recommended, in addition to routine HE

    A case of intra-abdominal pseudomycetoma in a short hair domestic cat

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    Lo scopo del lavoro è descrivere un caso di pseudomicetoma intraddominale in un gatto comune europeo, evento segnalato precedentemente in questa specie in un solo caso negli Stati Uniti in un gatto di razza persiana. L’esame istologico di una mas- sa intraddominale ha permesso di evidenziare clamidoconidi ed ife settate in materiale Splendore-Hoeppli localizzati a livello ve- scicale e peritoneale. Il caso descritto presenta caratteristiche di peculiarità dal momento che normalmente gli pseudomicetomi colpiscono i gatti di razza persiana a livello cutaneo e sottocutaneo e, raramente (1 solo caso), a livello intraddominale. Summary The aim of this work is to describe a case of an intra-abdominal pseudomycetoma in a short hair domestic cat, an event de- scribed before only once in the USA in a Persian cat. The histologic examination of an intra-abdominal mass revealed the pre- sence of chlamydoconidia and hyphae in a Splendore-Hoeappli material at the level of peritoneum and bladder wall. The pecula- rity of the described case is consistent of the intra-abdominal localization of the pseudomycetoma in a short hair domestic cat. This lesion usually affects the Persian cat with skin and subcutaneous localization, rarely (1 case) with intra-abdominal site

    THREE CASES OF CANINE TUMORS WITH LEISHMANIA-LADEN NEOPLASTIC CELLS

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    Concurrent leishmaniasis and neoplasia, although rare, have been already reported in humans and dogs. This study describes the presence of this protozoon within the cytoplasm of neoplastic cells in three different tumors. Specifically, Leishmania amastigotes were detected by immunohistochemistry (IHC) in a T cell lymphoma, a fibrosarcoma and a corticosurrenalic adenoma. Furthermore transmission electron microscopy examination confirmed the intracytoplasmic localization of amastigotes within the neoplastic cells and in occasional mitotic cells. Only two papers have been published in dog describing similar features, but the new interesting finding of this study is the association – never reported before – between this protozoon and neoplasms with different histogenesis. Despite currently it is not possible to explain the relationship between the parasitic infection and the neoplastic disease, we rule out that the co-existence of the Leishmania and neoplasia is merely coincidental. Finally, for the first time the anti-KMP11 antibody is used to detect Leishmania amastigotes in canine tissue by IHC: it could become a powerful diagnostic tool to confirm the presence of the parasite, especially when barely detectable

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    A case of Hodgkin-like lymphoma in a cat, comparative pathological features with the human disease

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    Il linfoma Hodgkin (LH), neoplasia linfoproliferativa maligna, è ben documentato nell’uomo. Tale patologia è caratterizzata dalla presenza di cellule di Reed-Sternberg (RS) e/o loro varianti in un background infiammatorio e stromale tipico. La prognosi è migliore rispetto ai linfomi non Hodgkin (LNH) ed è correlata al quadro istologico ed alla stadiazione clinica. Istologicamente si riconoscono 4 tipi di LH: linfocitico predominante, a cellularità mista, nodulare sclerosante e con deplezione linfocitaria. Un gatto Persiano maschio castrato di 13 anni veniva visitato per linfoadenomegalia localizzata. L’esame istologico del linfonodo cervicale profondo medio aumentato di volume rivelava la presenza di cellule linfocitarie ed istiocitarie atipiche, occasional- mente anti-BLA.36 positive, rare cellule RS e cellule mummificate in un background infiammatorio, quadro suggestivo di LH. Il gatto moriva dopo 2 anni per cause non conosciute, ma confermando comunque, anche in questa specie, un tempo di so- pravvivenza superiore del LH rispetto al LNH. Summary Hodgkin’s Disease (HL), a malignant lymphoid neoplastic condition, has been well described in humans. It is characterized by the presence of Reed-Sternberg (RS) cells and/or their variants in a typical inflammatory and stromal background. Progno- sis is better than non Hodgkin’s lymphomas (NHL) and is correlated with histological features of the tumor and clinical stage. Histologically, 4 types of HL are recognized: lymphocyte-predominant, of mixed cellularity, nodular-sclerosing and with lymphocyte-depletion. A 13 year old neutered male Persian cat with localized lymphadenopathy of a cervical deep lymph node was presented for clinical examination. The histology of the enlarged lymph node revealed lymphocytic and histiocytic atypical cells, which occasionally expressed anti-BLA.36, and rare RS and mummified cells in an inflammatory background, being com- patible with HL. This animal survived for 2 years after diagnosis, confirming that HL has a better prognosis than NHL
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