1,720,954 research outputs found
Dermatite atopica in età pedaitrica: correlazione tra scorad. livelli sierici di vitamina d, parametri strumentali e sensibilizzazione ad enterotossine stafilococciche e a malassetia furfur.
No full textABSTRACT
La dermatite atopica è una patologia infiammatoria cronica recidivante della cute con eziopatogenesi complessa che vede strutturalmente un danno a livello dell’effetto barriera della cute. Recenti studi hanno evidenziato un possibile ruolo della vitamina D. La vitamina D infatti riduce l’espressione del CLA (cutaneous lymphocyte associated antigen) sulle cellule T, regolandone il reclutamento cutaneo; aumenta l’espressione di catelicidina a livello dei cheratinociti potenziando le difese antimicrobiche della cute. E’ emerso inoltre che dermatiti atopiche piu’ gravi spesso sono associate alla presenza di IgE anti-tossine stafilococciche.
Lo scopo del nostro studio è quindi quello di valutare se la gravità della patologia quantificata col punteggio SCORAD correli con i livelli sierici di vitamina D e con la presenza di IgE anti tossine stafilococciche e anti–Malassetia furfur e se il danno di barriere e la sensibilizzazione alle enterotossine stafilococciche siano influenzati dalla vitamina D stessa.
Materiali e metodi: la gravità della dermatite atopica è stata quantificata con il punteggio SCORAD che classifica la dermatite in lieve, moderata e grave valutando paramentri oggettivi di estensione e intensità e soggettivi come il prurito e la perdita di sonno. Come strumento di quantificazione del danno di barriera è stato usato il tewameter per misurare il TEWL (trans epidermal water loss). Il dosaggio delle IgE per enterotossine stafilococciche A, B, C e per Malassetia furfur è avvenuto su sangue periferico. Il dosaggio di vitamina D è stato considerato sufficiente per livelli > 30 ng/L, insufficienti >30 ng/L, carenti > 20 ng/L.
Risultati: la significatività dei dati e i confronti tra i vari gruppi studiati è avvenuta secondo il metodo statistico di analisi di regressione lineare. La correlazione tra il dosaggio della vitamina D e lo SCORAD è risultata significativa (p=0.0176; r=0.38). Tra vitamina D e TEWL non risulta significatività statistica come pure tra il dosaggio della vitamina D e quello delle IgE per tossine A,B,C e Malassetia f. La correlazione tra le sensibilizzazioni alle eterotossine e lo SCORAD non è risultato statisticamente significativo come pure tra la vitamina D e le sensibilizzazioni.
Conclusioni: I bambini con livelli sierici bassi di vitamina D presentano uno SCORAD piu’ alto e quindi maggior severità di malattia. Lo studio offre buoni presupposti per ulteriori studi sul trattamento della dermatite atopica con supplementazione di vitamina D.Atopic dermatitis is a chronic relapsing inflammatory skin disease with multifactorial etiology with a structural damage to the barrier of the skin. Recent studies have revealed a possible role of vitamin D. Indeed, vitamin D reduced the expression of CLA on the T cells, regulating the recruitment skin, increased the e3xpression of keratinocyte catelicidina at enhancing the antimicrobial defenses of the skin. Serious atopic dermatitis are often associated with the presence of IgE anti-staphylococcal toxins .
The aim of our study is therefore to assess whether the severity of the disease quantified with SCORAD scores correlated with serum levels of vitamin D and with the presence of IgE anti staphylococcal toxins and M. Furfur and if the damage to barriers and awareness staphylococcal eneterotoxins depend on vitamin D itself.
Materials and method: the severity of dermatitis was quantified by the SCORAD score that classifies the dermatitis in mild, moderate, serious using objective parameters as extent and intensity and subjective parameters as itching and sleep loss. To measure the trans epidermal water loss (TEWLS) we used tewameter. The IgE to staphylococcal enterotoxins A,B,C and to Malassetia furfur occurred on peripheral blood. The dose of vitamin D was considered sufficient to level >30 ng/L, insufficient >30 ng/L, lacking <20 ng/L.
Results: the significativity of the date and the comparisons between the various groups studied was made by the statistical method of linear regression analysis. The correlation between the dose of vitamin D and the SCORAD was significant (p=0.016, r=0.38). Between vitamin D and TEWL is not statistically significant as well as between the does of vitamin D and IgE to enterotoxins A,B, C and M. furfur. The correlation between the sensitization and the SCORAD was not statistically significant as well as between vitamin D and sensitization.
Conclusions: children with low serum levels of vitamin D have a SCORAD more high and therefore greater severity of disease. The study provides a good basis for further studies on the treatment of atopic dermatitis with supplementation of vitamin D
Il respiro disfunzionale nel bambino.
No full textIn età pediatrica pattern anomali della respirazione possono causare lo sviluppo di sintomi caratteristici e interferire con la qualità di vita
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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