1,721,362 research outputs found
Systems Precision Medicine: Putting the Pieces Back Together
Full text linkSystems precision medicine is an interdisciplinary approach that recognises the complexity of diseases and emphasises the integration of clinical knowledge, multi-omics data, analytical models, and the expertise of physicians and data analysts to personalise the care pathway in complex diseases, such as cancer or diabetes. The aim is to gain a comprehensive understanding of diseases by analysing individual components and identifying relevant aspects for therapy and diagnosis. Key components, their interactions and emerging patterns can be studied using statistical, mathematical and computational tools. The combination of data analysis and clinical evaluation is crucial to effective decision-making, emphasising the need for an integrative approach rather than relying on data alone. Therefore, the crucial point discussed in this paper is that the “computational” part and the “artistic” part (i.e., the physician’s intuition) cannot be separated, and therefore, systems precision medicine can be configured as a collective work of art, involving not only different medical professionals but also, and above all, professional data analysts. The work is “artistic” because data and mathematics alone, without medical knowledge of the context, are not enough. But the work is also “collective” in the sense that it must be the place of cultural integration between the professional intuition of the physician, which cannot be translated into mathematical formulas, and the ability to extract information from multi-omics data of the data analysts, who instead use formal and computational mathematical methods. However, to drive the medical revolution and reassemble a patient’s parts, data analysts need to be involved in the hospital context, and precision medicine physicians should embrace data analytical perspectives. This will require ongoing dialogue, new languages of communication, and education that promotes continuous learning and collaboration between professions, fostering a new level of interdisciplinary collaboration for personalised care
Erratum: "A note on minimality of positive realizations" (IEEE Transactions on Circuits and Systems)
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Revisiting the linear recursions with nonnegative coefficients problem
Full text linkThe purpose of this paper is to state the correct formulation of a theorem proposed by M. Roitman and Z. Rubinstein on the characterization of linear recursions which imply a linear recursion with nonnegative coefficients. The authors present a counterexample to such a theorem and then state its correct formulation
Positive Dynamical Systems: New Applications, Old Problems
Full text linkThis review paper presents four relevant and very recent real-world application problems demanding developments of long-standing theoretical open problems in the field of positive systems research. Notably, the selected applications belong to very different fields of science and technology, ranging from biology and medicine to civil and electronic engineering. This clearly shows how pervasive positive systems are in mainstream research. Additionally, the theoretical issues stemming from these applications are the living proofs of how the apparently simple positivity constraint on the variables of interest makes the theory behind practical problems far from trivial, even for the linear case
Topological analysis of migration flows (the case of political refugees)
No full textIn this paper, using complex network theory we analyse the problem of illegal immigration on a worldwide scale. This approach appears to be appropriate in view of the invariance of scale property that we found in real data. The presented networks have been obtained using publicly available data collected from 2000 to 2011 by the UNHCR database (asylum-seekers) which is reasonably reliable, complete and regularly updated. Preliminarily, we show the roles played by a number of key nodes and clusters. Then, to find 'important' nodes, we use a role definition which is a variant of that introduced by Guimerà and Amaral (the so-called cartography approach). Finally, a coloured cartography of the clusters obtained through a geopolitical map of the world provides an easy-to-read visual tool to highlight results in a way also suitable to a broader non-technical audienc
La logica fuzzy quale supporto decisionale per la manutenzione preventiva delle reti fognarie
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Sepolture bizantine dall’Acropoli di Segesta (TP): analisi antropologica.
No full textAnalisi tafonomica, antropologica e paleopatologica di alcune sepolture altomedievali rinvenute sull'acropoli di Segesta (Trapani)
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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