1,721,007 research outputs found

    Mild reduction of carboxylic acids to alcohols using cyanuric chloride and sodium borohydride

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    Several carboxylic acids, including N-Boc, N-Cbz and N-Fmoc amino acids were reduced to the corresponding alcohols by activation of the carboxy function with cyanuric chloride and N-methylmorpholine followed by reduction with aqueous sodium borohydride. (C) 1999 Elsevier Science Ltd. All rights reserved

    Synthesis of amphiphilic polyhydroxylated pyrrolidines as potential glycosidase inhibitors

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    Several polyhydroxylated pyrrolidines with an aliphatic long chain on the ring nitrogen were prepared starting from D-mannitol. An amphiphilic bis-azasugar scaffold has been also prepared. These products behave as cationic surfactants and show a promising anti HIV-I activity. (C) 1998 Elsevier Science Ltd. All rights reserved
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