1,720,961 research outputs found
Basal cell carcinoma with fibroepithelioma-like histology in a healthy child: report and review of the literature
No full text
Gastric diffuse large B-cell lymphoma (DLBCL) exhibiting oral acanthosis nigricans and tripe palms
No full textApproximately one-third of non-Hodgkin lymphomas arise primarily
from sites other than lymph nodes, such as spleen or bone
marrow, and even from sites which normally contain no native
lymphoid tissue. The extranodal lymphomas represent a challenge
in routine lymphoma diagnosis, due to the variety of histological
types, molecular abnormalities and clinical pictures [1]. Diffuse
large B-cell lymphoma (DLBCL) is the most common extranodal
lymphoma encountered in the gastrointestinal tract. This is mainly
a disease of older adults in the seventh decade, even though it may
occasionally affect children and young adults. It typically produces
large, destructive lesions that may invade adjacent structures [2].
A 74-year-old woman was referred to our Oral Medicine Unit
by the nearby Cardio-pulmonary Unit, where she was hospitalised
because of severe pneumonia refractory to the antibiotic therapy.
Here, routine haematological blood tests revealed lymphocytosis,
mild anemia, and a slightly elevated lactate dehydrogenase,
whereas a basic workup for underlying malignancy was normal,
except for a mild increase of beta2-microglubulin.
Clinically, diffuse micropapillary lesions on the hard palate and
inner upper lips (Fig. 1A), a “cerebriform” aspect of the right cheek
(Fig. 1B), and a velvety rugose appearance on palms and palmar
surface of the fingers on both hands (tripe palms) (Fig. 1C and D)
were detected. Oral biopsy revealed amarked epithelial thickening
with papillary hyperplasia, acanthosis, and slight dyskeratosis. The
dermal papillae project upward as finger-like projections with a
chronic lymphomonocytic inflammatory infiltrate (Fig. 1E).
Oral acanthosis nigricans (AN) associated with tripe palms was
suspected. Benign AN was excluded, because no associated syndrome,
obesity, or medical history of taking medicine was found.
The glycosylated haemoglobin level and insulin resistant testswere
normal. Conversely, malignant AN was confirmed by the presence
of a hyperplastic nodular mass, with a superficial erosion, on the
wall of the stomach.
A biopsy revealed features consistent with DLBCL, showing a
lymphoid infiltrate in the lamina propria with a predominance of
small to medium-sized and scattered large cells (Fig. 1F), which
turned out to be CD 20 positive (Fig. 1G), invaded and destroyed the
glandular epithelium that was pancytokeratin positive (Fig. 1H).
The stagewas EI2, according to theAnnArbor classificationmodified
by Musshoff [3], since a total body CT scan did not detect
any enlarged lymph nodes. The CT scan and tumour markers were
re-performed 1 month later, some days before her demise, with
negative results, as sometimes the primary tumour might not
be detected for a long time [4]. Thus, no other malignancy was
detected, reinforcing the association between gastric DLBCL and
malignant AN. The patient died due to severe cardio-pulmonary
complications.
AN is a rare mucocutaneous disorder, which is characterised by
cutaneous and oral papillary lesions [5]. It includes a benign and
a malignant form, which is associated with an underlying, often
aggressive, malignancy, either non-haematological [5] or haematological
[6].
The pathogenesis of malignant AN is still unclear. A possible
mechanism might involve the production of the transforming
growth factor alpha (TGF-), which is closely related to the epidermal
growth factor (EGF) and binds to the same receptor, EGFR. This
binding activates the classical mitogen-activated protein kinase
(MAPK, ERK) pathway, involved in regulating basic cellular functions
such as proliferation, differentiation, and migration [7]. Since
some type of cancers produce large amounts of TGF-, it is likely
that keratinocyte growth might be stimulated via an endocrine
route.Whether this pathogenetic mechanism might also be applied
to the DLBCL remains questionable and, thus, further investigations
are required
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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