1,720,958 research outputs found
Interaction of tributyltin(IV) chloride and related [Bu3 Sn(LSM)] complex with rat leukocytes and erythrocytes: effect on DNA and on plasma membrane
No full textThe discovery of the antitumor activity of cisplatin led several research groups to investigate the possible
therapeutic applications of othermetal-based compounds. Organotin(IV) complexes have been developed
from organotin compounds that were employed in industry and agriculture as stabilizers and pesticides,
respectively. A careful choice of the ligand coordinated to an organotin(IV) fragment can modulate the
activity of the organotin(IV) complex and minimize its drawbacks.With this aim, the tributyltin(IV) complex
[Bu3Sn(LSM)] (LSM= bis(1-methyl-1H-imidazol-2-ylthio)acetate) was synthesized and its in vitro
effects on rat blood cells were compared with those of the analogous tributyltin(IV) compound without
the anionic ligand.
Comet-assay results show that both the tributyltin(IV) chloride (TBTC) and the complex [Bu3Sn(LSM)]
can induce DNA damage in leukocytes, but a stronger effect was observed in the presence of the organotin(
IV) complex. Moreover, lipid-hydroperoxide formation in leukocyte plasma membranes increases
more in the presence of [Bu3Sn(LSM)] compared with TBTC, while TBTC can change the lipid order and
packing of leukocytes and, partially, erythrocyte plasma membranes. The treatment of whole blood with
these two compounds shows a preferential oxidative effect of TBTC on erythrocyte plasma membranes
and erythrocyte oxidative processes, which influence the induction of DNA damage in leukocytes. The
different hydrophobic characters and the different extents of steric hindrance of TBTC and [Bu3Sn(LSM)]
influence the capacity of the two compounds to cross the plasma membrane and affect the pathways that
lead to DNA damage
Effect of permethrin plus antioxidants on locomotor activity and striatum in adolescent rats
Full text linkPyrethroids are important insecticides used largely because of their high activity as an insecticide and
their low mammalian toxicity. Some studies have demonstrated that these products show neurotoxic
effects on the mammalian central nervous system.
The aim of the present study was to investigate the propensity of permethrin to induce oxidative stress
in adolescent rats and its possible attenuation by Vitamin E alone or + Coenzyme Q10. Data indicated
that adolescent rats exposed to permethrin exhibited alteration in the locomotor activity and plasma
membrane fluidity of striatum. Vitamin E +Q10 and Vitamin E alone supplementation reversed the negative
effect on central nervous system. Permethrin alteration of striatum plasma membrane fluidity was
restored by Vitamin E +Q10. Data obtained from red blood cells showed that permethrin did not induce
any modification of plasma membrane fluidity in adolescent rats, whereas antioxidants supplementation
induced pro-oxidant effect.
In summary some differences between antioxidant treatments were observed at striatum level: Coenzyme
Q10 + Vitamin E maintains plasma membrane fluidity, while Vitamin E is more effective to preserve
GSH level
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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