1,721,071 research outputs found
Imaging of cervical lymph node metastases in malignant jugular paraganglioma: Imaging of paraganglioma metastases
No full textNot availabl
Chondrosarcomas of the jugular foramen.
No full textLaryngoscope. 2008 Oct;118(10):1719-28.
Chondrosarcomas of the jugular foramen.
Sanna M, Bacciu A, Pasanisi E, Piazza P, Fois P, Falcioni M.
SourceOtology, Neurotology and Skull Base Surgery, Gruppo Otologico, Piacenza, Italy. [email protected]
Abstract
OBJECTIVES/HYPOTHESIS: Chondrosarcomas of the jugular foramen are extremely rare tumors. Our review of the literature revealed eleven previously reported cases. The aim of this study is to describe the presenting symptoms, radiographic findings, operative procedures, and postoperative outcome of five histologically confirmed cases of chondrosarcomas arising from the jugular foramen. A review of the literature is also presented.
STUDY DESIGN: Retrospective study of an quaternary referral otology and skull base private center.
METHODS: Five cases of surgically treated and pathologically confirmed jugular foramen chondrosarcomas were identified. The follow-up of the series ranged from 23 to 42 months (mean, 32.8 +/- 7.7 months).
RESULTS: A single stage procedure was adopted in all the cases. Two patients underwent type A infratemporal approaches, one patient underwent a transotic approach extending to the neck with ligature of the internal jugular vein, one patient underwent a petro-occipital transigmoid approach, and one patient underwent a combined petro-occipital transigmoid-transotic approach. Gross total tumor removal was achieved in all patients. The most common complications were lower cranial nerve deficits. To date, no recurrence or residual tumors have been observed at radiological controls.
CONCLUSIONS: We believe that the primary treatment for chondrosarcomas of the jugular foramen is gross total surgical resection of the tumor. It is our philosophy to reserve postoperative radiotherapy for patients with histologically aggressive tumors, as well as in cases with subtotal resection and recurrent tumors
Intracranial facial nerve grafting after removal of vestibular schwannoma
No full textAm J Otolaryngol. 2009 Mar-Apr;30(2):83-8. Epub 2008 Jul 22.
Intracranial facial nerve grafting after removal of vestibular schwannoma.
Bacciu A, Falcioni M, Pasanisi E, Di Lella F, Lauda L, Flanagan S, Sanna M.
SourceDepartment of Otolaryngology, University of Parma, Parma, Italy. [email protected]
Abstract
OBJECTIVE: The objectives of this study were to evaluate outcomes from facial nerve (FN) cable grafting in patients who experienced FN transection during vestibular schwannoma removal and to compare the FN outcomes of patients who underwent FN grafting by using fibrin glue with those of patients who underwent FN grafting by using microsuture.
MATERIAL AND METHODS: We retrospectively evaluated a series of 33 patients in whom FN grafting was achieved either by using microsuture (8 cases) or fibrin glue (25 cases). Immediate repair of the FN was performed in all cases at the time of initial resection. The patients FN function was assessed preoperatively, in the immediate postoperative period, and at 3, 6, 9, and 12 months or more postoperatively using the House-Brackmann grading system. All patients had at least 1-year follow-up.
RESULTS: At 12 months, a House-Brackmann grade III was achieved in 75% of those who underwent cable nerve graft interposition by using microsuture and in 76% of those who underwent cable nerve graft interposition by using fibrin glue. Analysis of final FN function outcomes demonstrated no statistically significant difference in FN outcomes between the 2 groups (P = .891, Mann-Whitney U test; P = .1, Fisher exact test).
CONCLUSIONS: The functional results after FN cable grafting by using fibrin glue exclusively were equivalent to those obtained with microsuture. However, the technique of FN repair by means of fibrin glue is technically simple, less time-consuming, and imparts less trauma on the nerve than does the traditional suture method
Correlation functions and relaxation properties in chaotic dynamics and statistical mechanics
No full textInteraction of tributyltin(IV) chloride and related [Bu3 Sn(LSM)] complex with rat leukocytes and erythrocytes: effect on DNA and on plasma membrane
No full textThe discovery of the antitumor activity of cisplatin led several research groups to investigate the possible
therapeutic applications of othermetal-based compounds. Organotin(IV) complexes have been developed
from organotin compounds that were employed in industry and agriculture as stabilizers and pesticides,
respectively. A careful choice of the ligand coordinated to an organotin(IV) fragment can modulate the
activity of the organotin(IV) complex and minimize its drawbacks.With this aim, the tributyltin(IV) complex
[Bu3Sn(LSM)] (LSM= bis(1-methyl-1H-imidazol-2-ylthio)acetate) was synthesized and its in vitro
effects on rat blood cells were compared with those of the analogous tributyltin(IV) compound without
the anionic ligand.
Comet-assay results show that both the tributyltin(IV) chloride (TBTC) and the complex [Bu3Sn(LSM)]
can induce DNA damage in leukocytes, but a stronger effect was observed in the presence of the organotin(
IV) complex. Moreover, lipid-hydroperoxide formation in leukocyte plasma membranes increases
more in the presence of [Bu3Sn(LSM)] compared with TBTC, while TBTC can change the lipid order and
packing of leukocytes and, partially, erythrocyte plasma membranes. The treatment of whole blood with
these two compounds shows a preferential oxidative effect of TBTC on erythrocyte plasma membranes
and erythrocyte oxidative processes, which influence the induction of DNA damage in leukocytes. The
different hydrophobic characters and the different extents of steric hindrance of TBTC and [Bu3Sn(LSM)]
influence the capacity of the two compounds to cross the plasma membrane and affect the pathways that
lead to DNA damage
[Coexistence of vestibular schwannoma and glomus tympanicum tumor].
No full textSimultaneous occurrence of a vestibular schwannoma and a glomus tympanicum tumor has been reported only once in the international literature. The authors present a second case: a 72-year-old woman having a glomus tympanicum tumor and an ipsilateral lesion confined to the internal auditory canal, radiologically diagnosed as an acoustic neuroma. Due to the patient's age, symptoms, hearing threshold and the small size of both tumors the decision was made not to perform surgery. The patient will be regularly followed-up through computerized tomography and magnetic resonance imaging
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