131,004 research outputs found
– « Que fais-tu ? » – « Je suis psychologue... »
No full textBoistel D. – « Que fais-tu ? » – « Je suis psychologue... ». In: Bulletin de psychologie, tome 36 n°358, 1982. Psychologie clinique V. Les psychologues cliniciens. pp. 29-31
Fais qu\u27il ne m\u27aime pas : romance
No full textFais qu\u27il ne m\u27aime pas; je t\u27en prie à genoux,O toi, mon Dieu, qui connais mes a larmes;Son regard si touchant,Son langage si doux,M\u27apportent du bonheur; et je verse des larmes!...Oh! par pitié, mon Dieu, fais qu\u27il ne m\u27aime pas!Oh! par pitié, mon Dieu, fais qu\u27il ne m\u27aime pas, fais qu\u27il ne m\u27aime pas!
Fais qu\u27il ne m\u27aime pas; car, moi, je l\u27aimerais,De cet amour qui rend triste et charmé;Un jour, s\u27il m\u27aimait moins, tu le sais, j\u27en mourrais,Ce n\u27est plus vivre, hélas! que d\u27être moins aimée!...Oh! par pitié, mon Dieu, fais qu\u27il ne m\u27aime pas!Oh! par pitié, mon Dieu, fais qu\u27il ne m\u27aime pas, fais qu\u27il ne m\u27aime pas!
Fais qu\u27il ne m\u27aime pas; j\u27implore ton secours;Et de ses veux, dérobe moi la plainte!...Ici, j\u27aimerai sans crainte!...Fais ici bas, mon Dieu, que je ne l\u27aime pas!Fais par pitié, mon Dieu, que je ne l\u27aime pas, que je ne l\u27aime pas
Guidelines for Testing Drugs under International Control in Hair, Sweat and Oral Fluid
No full textThe present Manual is a revision of the United Nations Office on Drugs and Crime (UNODC) manual Guidelines for Testing Drugs Under International Control (ST/NAR/30/Rev.2). This version has been prepared taking into account recent developments in analytical technology to detect conventional and new, unconventional drugs and is based on up-to-date scientific knowledge of the physiology and pharmacology
of the so-called “alternate” biological specimens, which today may offer important information, complementary to the analysis of the traditional biological specimens (blood and urine)
MeSH term explosion and author rank improve expert recommendations
No full textInformation overload is an often-cited phenomenon that reduces the productivity, efficiency and efficacy of scientists. One challenge for scientists is to find appropriate collaborators in their research. The literature describes various solutions to the problem of expertise location, but most current approaches do not appear to be very suitable for expert recommendations in biomedical research. In this study, we present the development and initial evaluation of a vector space model-based algorithm to calculate researcher similarity using four inputs: 1) MeSH terms of publications; 2) MeSH terms and author rank; 3) exploded MeSH terms; and 4) exploded MeSH terms and author rank. We developed and evaluated the algorithm using a data set of 17,525 authors and their 22,542 papers. On average, our algorithms correctly predicted 2.5 of the top 5/10 coauthors of individual scientists. Exploded MeSH and author rank outperformed all other algorithms in accuracy, followed closely by MeSH and author rank. Our results show that the accuracy of MeSH term-based matching can be enhanced with other metadata such as author rank
La rendición de cuentas de transferencias intergubernamentales: el caso del FAIS
No full textEste texto analiza el marco legal y el funcionamiento de la rendición de cuentas de las aportaciones federales, en concreto del Fondo de Aportaciones para la Infraestructura Social (FAIS). El trabajo muestra que el FAIS tiene un déficit serio en materia de rendición de cuentas, pues, tal como opera al día de hoy, es imposible garantizar: a) que quienes deben rendir cuentas lo hagan, b) que quienes deben vigilarlos cuenten con instrumentos para hacerlo, c) que se expliquen y justifiquen los resultados del desempeño del FAIS, y, con todo ello, d) que el ciudadano tenga información y pueda exigir cuentas a los responsables sobre las consecuencias de las decenas de miles de millones de pesos que desde 1998 se han destinado a este fondo.This paper analyzes the legal framework and the accountability process of the conditional transfer for social infrastructure (Fondo de Aportaciones Federales para la Infraestructura Social, FAIS). We show that, as FAIS works right now, there is a serious accountability deficit that makes it impossible to guarantee: a) that the authorities responsible for the use of these funds will be accountable, b) that the mechanisms for oversight work correctly, c) that the impact of these funds will be explained or justified, and d) that citizens will have enough information for holding accountable those responsible for the use of billions of pesos that have been assigned to this fund since 1998
General-purpose data stream processing on heterogeneous architectures with WindFlow
No full textMany emerging applications analyze data streams by running graphs of communicating tasks called operators. To develop and deploy such applications, Stream Processing Systems (SPSs) like Apache Storm and Flink have been made available to researchers and practitioners. They exhibit imperative or declarative programming interfaces to develop operators running arbitrary algorithms working on structured or unstructured data streams. In this context, the interest in leveraging hardware acceleration with GPUs has become more pronounced in high-throughput use cases. Unfortunately, GPU acceleration has been studied for relational operators working on structured streams only, while non-relational operators have often been overlooked. This paper presents WINDFLOW, a library supporting the seamless GPU offloading of general partitioned-stateful operators, extending the range of operators that benefit from hardware acceleration. Its design provides high throughput still exposing a high-level API to users compared with the raw utilization of GPUs in Apache Flink
Neuroprotective Effects of Myrtle Berry By-Product Extracts on 6-OHDA-Induced Cytotoxicity in PC12 Cells
No full textThe rising global focus on healthy lifestyles and environmental sustainability has prompted interest in repurposing plant-based by-products for health benefits. With increasing life expectancy, the incidence of neurodegenerative diseases-characterized by complex, multifactorial mechanisms such as abnormal protein aggregation, mitochondrial dysfunction, oxidative stress, and inflammation-continues to grow. Medicinal plants, with their diverse bioactive compounds, offer promising therapeutic avenues for such conditions. Myrtus communis L., a Mediterranean plant primarily used in liquor production, generates significant waste rich in antioxidant and anti-inflammatory properties. This study explores the neuroprotective potential of Myrtus berry by-products in a cellular model of neurodegeneration. Using PC12 cells exposed to 6-hydroxydopamine (6-OHDA), we assessed cell viability via MTT assay and measured reactive oxygen species (ROS) production using DCFDA fluorescence. Additionally, we analyzed the expression of genes linked to oxidative stress and neuronal function, including AChE, PON2, Grin1, Gabrd, and c-fos, by RT-PCR. Our findings reveal that Myrtus extract significantly protects against 6-OHDA-induced cytotoxicity, reduces ROS levels, and modulates the expression of key stress-related genes, underscoring its potential as a neuroprotective agent. These results highlight the therapeutic promise of Myrtus extracts in mitigating neurodegenerative processes, paving the way for future interventions
IDENTIFICATION OF THREE DISTINCT SUBGROUPS OF B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA BASED UPON MUTATIONS OF BCL-6 AND IgV GENES
No full textAlthough B cell chronic lymphocytic leukemia (B-CLL) has been traditionally viewed as a tumor of virgin B cells, this notion has been recently questioned by data suggesting that a fraction of B-CLL derives from antigen experienced B cells. In order to further clarify the histogenetic derivation of this lymphoproliferation, we have analyzed the DNA sequences of the 5' non-coding region of BCL-6 proto-oncogene in 28 cases of B-CLL. Mutations of BCL-6 proto-oncogene, a zinc finger transcription factor implicated in lymphoma development, represent a histogenetic marker of B cell transit through the germinal center (GC) and occur frequently in B cell malignancies derived from GC or post-GC B cells. For comparison, the same tumor panel was analyzed for somatic mutations of the rearranged immunoglobulin variable (IgV) genes, which are known to be acquired at the time of B cell transit through the GC. Sequence analyses of BCL-6 and IgV genes allowed the definition of three groups of B-CLL. Group I B-CLL displayed mutations of both BCL-6 and IgV genes (10/28; 36%). Group II B-CLL displayed mutated IgV genes, but a germline BCL-6 gene (5/28; 18%). Finally, group III B-CLL included the remaining cases (13/28; 46%) that were characterized by the absence of somatic mutations of both BCL-6 and IgV genes. Overall, the distribution of BCL-6 and IgV mutations in B-CLL reinforce the notion that this leukemia is histogenetically heterogeneous and that a substantial subgroup of these lymphoproliferations derives from post-germinal center B cells
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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