131,094 research outputs found
Mitigation of seismic hazard of a megacity: the case of Naples
No full textThe seismic ground motion of a test area in the eastern district of Naples was computed with a hybrid technique based on the rnode surnrnation and the finite difference methods. This technique allowed the realistic modelling of source and propagation effects, including local soil conditions. In the modelling, as seismic source we considered the 1980 Irpinia earthquake, a good example of strong shaking for the area of Naples, located about 90 km from the source. Along a profile through Naples, trencling N86°W, the subsoil is mainly formed by alluvial (ash, stratified sand and peat) and pyroclastic materials overlying a pyroclastic rock (yellow Neapolitan tuff) representing the Neapolitan bedrock. The detailed information available on the subsoil mechanical properties and its geometry warrants the application of the sophisticated hybrid technique. For SH waves, a comparison was made between a realistic 2-D seismic response and a standard I-D response, based on the vertical propagation of waves in a plane layered structure. As expected the sedimentary cover caused an increase in the signal's amplitudes and duration. If a thin uniform peat layer is present, the amplification effects are reduced, and the peak ground accelerations are similar to those observed for the bedrock model. This can be explained by the backscattering of wave energy at such a laqer. The discrepancies evidenced between the l -D and the 2-D seismic response suggest that serious caution must be taken in the formulation of seismic regulations. This is particularly true in the presence of the thin peat laqer where the misinatch between the l -D and the 2-D amplification functions is particularly evident in correspondence of the dominant peak and of the second significant peak
Thai Local Chicken Breeds, Chee Fah and Fah Luang, Originated from Chinese Black-Boned Chicken with Introgression of Red Junglefowl and Domestic Chicken Breeds
No full textKnowledge of the genetic characteristics, origin, and local adaptation of chickens is essential to identify the traits required for chicken breeding programs. Chee Fah and Fah Luang are black-boned chicken breeds reared in Chiang Rai, Thailand. Chickens are an important part of the local economy and socio-culture; however, the genetic diversity, characteristics, and origins of these two breeds have been poorly studied. Here, we investigated the genetic diversity, gene pool, and origin of the Chee Fah and Fah Luang chickens using mitochondrial DNA D-loop (mtDNA D-loop) sequencing and microsatellite genotyping, as well as habitat suitability analysis using maximum entropy modeling. The MtDNA D-loop sequencing and microsatellite genotype analyses indicated that the Chee Fah and Fah Luang chickens shared haplogroups A, B, and CD with Chinese black-boned chickens. Gene pool analysis revealed that the Chee Fah and Fah Luang chickens have distinct genetic patterns compared to Thai domestic chickens and red junglefowl. Some gene pools of red junglefowl and other Thai domestic chickens were observed within the Chee Fah and Fah Luang chicken gene pool structures, suggesting genetic exchange. The data indicate that the Chee Fah and Fah Luang chickens originated from Chinese indigenous black-boned chicken breeds and experienced crossbreeding/hybridization and introgression with red junglefowl and other domestic breeds during domestication. Interestingly, the Chee Fah and Fah Luang chickens from Chiang Rai shared the same allelic gene pool, which was not shared with the Chee Fah and Fah Luang chickens from Mae Hong Son, suggesting at least two gene pool origins in the Chee Fah and Fah Luang chicken populations. Alternatively, different gene pools in the Chee Fah and Fah Luang chickens from different localities might be caused by differences in environmental factors, especially elevation
Penerapan ketentuan pidana dan tanggung jawab dalam kasus penghinaan terhadap pejabat negara yang dilakukan oleh media cetak (studi kasus Bersihar Lubis) / oleh Indriyuni Fah
No full textabstrak (A) Nama: Indriyuni Fah (NIM: 205010200) (B) Judul Skripsi: Penerapan Ketentuan Pidana dan Tanggung Jawab Dalam Kasus Penghinaan Terhadap Pejabat Negara yang Dilakukan Oleh Media Cetak (Studi Kasus Bersihar Lubis) (C) Halaman: vii + 118 + 23 (D) Kata Kunci: Pers Indonesia, Hukum Pidana (E) Isi: Berita dengaan judul ?Kisah Interogator yang Dungu? yang terbit pada Koran Tempo Edisi Sabtu Tanggal 17 Maret 2007 yang ditulis oleh wartawan Bersihar Lubis yang dilaporkan ke Polres Depok oleh pihak Kejaksaan Depok sebagai delik pembinaan terhadap pejabat negara dengan dakwaan Pasal 207 KUHP. Penerapan KUHP terhadap kasus Bersihar Lubis tempat digunakan karena UU Pers yang bersifat khusus tidak mengatur tindak pidana penghinaan yang dilakukan oleh wartawan sehingga tidak dapat diberlakukan asas Lex Specialis. Dalam tindak pidana penghinan Pers yang dapat dimintai pertanggung jawaban pidana menurut KUHP tidak hanya wartawan sebagai penulis, tapi juga dapat dimintai pertanggungjawabannya kepada pimpinan umum dan redaksinya. Metode penelitian yang digunakan dalam penyusunan Skripsi ini adalah metode penelitian normatif. (F) Acuan: 25 (G) Pembimbing: Bapak Sugandi Ishak, S.H., M.H. (H) Penulis: Indriyuni Fa
Seismic Ground Motion Expected for the Eastern District of Naples
No full textThe seismic ground motion of a test area in the eastern district of Naples is computed with a hybrid technique based on the mode summation and the finite difference methods. This technique allows us the realistic modelling of source and propagation effects, including local soil conditions. In the modelling, we consider the 1980 Irpinia earthquake, a good example of strong shaking for the area of Naples, which is located about 90 km from the epicenter.
The detailed geological setting is reconstructed from a large number of drillings. The sub-soil is mainly formed by alluvial (ash, stratified sand and peat) and pyroclastic materials overlying a pyroclastic rock (yellow neapolitan tuff). representing the neapolitan bedrock. The detailed information available on mechanical properties of the sub-soil and its geometry warrants the application of the sophisticated hybrid technique.
As expected, the sedimentary cover causes an increase of the signal's amplitudes and duration. If thin peat layers are present, the amplification effects are reduced, and the peak ground accelerations are similar to those observed for the bedrock model. This can be explained by the backscattering of wave energy at such layers, that tend to seismically decouple the upper from the lower part of the structure.
For SH-waves, the influence of the variations of the S-wave velocities on the spectral amplification is studied, by considering locally measured velocities and values determined from near-by-down-hole measurements. The comparison between the computed spectral amplifications confirms the key role of an accurate determination of the seismic velocities of the different layers.
The comparison performed between a realistic 2-D seismic response and a standard 1-D response, based on the vertical propagation of waves in a plane layered structure, shows considerable difference, from which it is evident that serious caution must be taken in the modelling of expected ground motion at a specific site
Syngeneic BMT rescure <i>fah<sup>-/-</sup></i> mice from liver failure by BM-derived hepatocytes.
No full text<p>(A-B) Body weight (A) and serum ALT (B) from recipient <i>fah<sup>-/-</sup></i> mice after syn-BMT. NTBC was withdrawn on day 28 after BMT, and initial body weight was set as 100% (dotted line). Gray areas indicate NTBC administration, white areas indicate NTBC withdrawal. *p<0.05, **p<0.01, ***p<0.001. (mean ± SEM, n = 9). (C) Survival rate measurements from recipient <i>fah<sup>-/-</sup></i> mice after NTBC withdrawal. No BMT <i>fah<sup>-/-</sup></i> mice without NTBC treatment were set as a control. (D) EGFP<sup>+</sup> hepatocytes from a BMT mouse by FACS (rebuild 57w). EGFP<sup>+</sup> hepatocytes in other BMT mice are shown in the table below. (E) Donor-derived hepatocytes in BMT mouse 407. Freshly isolated mouse hepatocytes in bright field (left) and under fluorescence (right) are shown above, and EGFP (left) and FAH (right) immunohistochemistry in liver are shown below (brown staining indicates positive cells).</p
A compensatory U1snRNA partially rescues FAH splicing and protein expression in a splicing-defective mouse model of tyrosinemia type I
No full textThe elucidation of aberrant splicing mechanisms, frequently associated with disease has led to the development of RNA therapeutics based on the U1snRNA, which is involved in 5′ splice site (5′ss) recognition. Studies in cellular models have demonstrated that engineered U1snRNAs can rescue different splicing mutation types. However, the assessment of their correction potential in vivo is limited by the scarcity of animal models with the targetable splicing defects. Here, we challenged the U1snRNA in the FAH5961SB mouse model of hepatic fumarylacetoacetate hydrolase (FAH) deficiency (Hereditary Tyrosinemia type I, HT1) due to the FAH c.706G>A splicing mutation. Through minigene expression studies we selected a compensatory U1snRNA (U1F) that was able to rescue this mutation. Intriguingly, adeno-associated virus-mediated delivery of U1F (AAV8-U1F), but not of U1wt, partially rescued FAH splicing in mouse hepatocytes. Consistently, FAH protein was detectable only in the liver of AAV8-U1F treated mice, which displayed a slightly prolonged survival. Moreover, RNA sequencing revealed the negligible impact of the U1F on the splicing profile and overall gene expression, thus pointing toward gene specificity. These data provide early in vivo proof-of-principle of the correction potential of compensatory U1snRNAs in HTI and encourage further optimization on a therapeutic perspective, and translation to other splicing-defective forms of metabolic diseases
What Drives Fixed Asset Holding and Risk-Adjusted Performance of Corporate in China? An Empirical Analysis
No full textThis paper attempts to shed light on the over-investment debate by investigating listed firms in China. Firms with higher level of fixed asset holding, higher level of overhead expenses, and being covered by the tax-favor policy in China are found to be associated with a lower risk-adjusted performance. In addition, the tax-favor policy itself encourages fixed asset investment. In contrast to some of the previous literature, state-ownership of firms, dividend policy, and ownership concentration are not robust predictors of risk-adjusted performance, and debt level, managerial shareholding, and profit per unit of asset are not robust predictors of fixed asset investment.fixed asset holding, corporate real estate, over-investment theory, state-ownership, tax-favor policy
Kritik Terhadap Pemahaman Ḥizb Al-Taḥrīr Atas Hadis-Hadis Khilāfah
No full textPenelitian ini berawal dari asumsi dasar bahwa pemahaman H{izb al-Taḥri>r
terhadap hadis-hadis yang selama ini mendasari gagasan menegakkan khila>fah tak
memiliki basis legitimasi yang kuat dalam teks-teks klasik Islam, terutama dalam
beberapa kitab syarah} hadis. Tak hanya itu, sejauh pengamatan saya, tampak
terlihat adanya pemaksaan logika yang dilakukan H{izb al-Taḥri>r dalam
memahami hadis-hadis khila>fah sehingga tiba pada sebuah kesimpulan bahwa
penegakkan khilāfah merupakan sebuah keniscayaan. Hal itu sebagaimana dapat
dijumpai dalam kitab al-Syakhs}iyyah al-Isla>miyyah karya Taqī al-Dīn al-Nabhānī
(pendiri H{izb al-Taḥri>r). Terlepas dari itu, hal ini memicu saya untuk meneliti
lebih jauh bahkan merekonstruksi sehingga dapat diketahui tentang bagaimana
makna yang sesungguhnya dari hadis-hadis khila>fah.
Penelitian dimulai dengan cara melacak sekaligus menginventarisir
seluruh ragam periwayatan hadis-hadis khila>fah. Hal itu dilakukan dengan
harapan dapat menemukan riwayat yang lebih spesifik sehingga potensial saling
menafsirkan dan memberikan pemaknaan signifikan satu sama lain. Selanjutnya,
hadis-hadis khila>fah yang ada, akan coba ditarik ke belakang dan dipahami
menurut konteksnya masing-masing sehingga dapat memahaminya secara utuh,
bukan secara parsial. Tak cukup sampai di situ, beberapa terminologi yang
berkaitan erat dengan khila>fah juga akan coba ditelusuri konteks penggunaannya
dalam teks-teks suci keagamaan.
Pada akhirnya, skripsi ini akan mendelegitimasi pemahaman H{izb al-
Taḥri>r atas hadis-hadis khila>fah, sekaligus menunjukan adanya kekeliruan yang
mereka lakukan dalam memahami hadis Nabi saw. Tak hanya itu, skripsi ini juga
akan menunjukan bahwa makna hadis-hadis yang selama ini mendasari gagasan
H{izb al-Taḥri>r tidaklah menunjukan pada keharusan menegakkan khila>fah sebagai
sistem pemerintahan Islam, melainkan hanya sebuah perintah atau tuntutan
kepada umat Islam agar menjaga keutuhan dan ketaatan terhadap seorang
pemimpin
MeSH term explosion and author rank improve expert recommendations
No full textInformation overload is an often-cited phenomenon that reduces the productivity, efficiency and efficacy of scientists. One challenge for scientists is to find appropriate collaborators in their research. The literature describes various solutions to the problem of expertise location, but most current approaches do not appear to be very suitable for expert recommendations in biomedical research. In this study, we present the development and initial evaluation of a vector space model-based algorithm to calculate researcher similarity using four inputs: 1) MeSH terms of publications; 2) MeSH terms and author rank; 3) exploded MeSH terms; and 4) exploded MeSH terms and author rank. We developed and evaluated the algorithm using a data set of 17,525 authors and their 22,542 papers. On average, our algorithms correctly predicted 2.5 of the top 5/10 coauthors of individual scientists. Exploded MeSH and author rank outperformed all other algorithms in accuracy, followed closely by MeSH and author rank. Our results show that the accuracy of MeSH term-based matching can be enhanced with other metadata such as author rank
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