1,721,009 research outputs found
Humoral response to influenza hemagglutinin: oligoclonal spectrotype and failure of thymopentin as immunoadjuvant
No full textTreatment of active chronic hepatitis with cyclophosphamide.
No full textTwenty patients with active chronic hepatitis, classified on the basis of the treatment into three groups, have been studied: (1) patients treated with cyclophosphamide (10 patients); (2) patients treated with cyclophosphamide after cycles of corticosteroid therapy (four patients); (3) patients treated with corticosteroid (six patients).
In all patients we observed clinical, biochemical and immunological changes during and after treatment.
Hepatic needle-biopsy was performed in all patients before treatment. The histological picture was rechecked after the first cycle of therapy in twelve patients.
The results obtained in the three groups of patients have been statistically compared.
Cyclophosphamide treatment produces an improvement of general conditions and a persistent normalization of several biochemical and immunological data, especially in those patients in which active chronic hepatitis was not in an advanced stage (type A aggressive form). The histological picture showed no changes after treatment
No linkage between HLA and congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency.
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Life-threatening anaphylactic shock caused by porcine heparin intravenous during mitral valve repair
No full textTreatment of Rheumatoid arthritis by murine antiidiotypic monoclonal antibodies to syngeneic anti-HLA Class II monoclonal antibodies: preliminary results
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Monoclonal antibodies to HLA Class II antigens in the treatment of rheumatoid arthritis: a phase I clinical trial
No full textLife-threatening anaphylactic shock caused by porcine heparin intravenous infusion during mitral valve repair.
No full textTHYROID AUTOIMMUNITY AND AGING
No full textAgeing is associated with the appearance of several serum autoantibodies, including thyroid autoantibodies. The biological and clinical significance of this phenomenon is still unknown, since, with the exception of primary myxedema, the prevalence of clinically overt thyroid autoimmune diseases is not increased in the elderly. The peculiar link between autoimmune thyroid failure and ageing is also underscored by the high prevalence of subclinical hypothyroidism in elderly subjects with positive serum thyroid autoantibodies, and could be the consequence of preferential age-dependent expression of destructive effector mechanisms and/or increased target gland susceptibility. Thyroid autoimmunity and subclinical hypothyroidism have also been implicated in the pathogenesis of other age-associated disorders, in particular coronary heart disease. Interestingly, recent data from our laboratories showed that thyroid autoantibodies are rare in healthy centenarians and in other highly selected aged populations, while they are frequently observed in unselected or hospitalized elderly. Taken together, these data suggest that thyroid autoimmune phenomena are not the consequence of the ageing process itself, but rather might be related to age-associated disease
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