1,720,961 research outputs found
Glial cell line-derived neurotrophic factor in Purkinje cells of adult zebrafish: an autocrine mode of action?
No full textGlial cell line-derived neurotrophic factor (GDNF) has a neuroprotective role in Purkinje cells of cerebellum,
promoting the survival and the differentiation of these cells. Its signalling is mediated by a receptorial
complex GFRalpha1/RET. In the brain of adult zebrafish (Danio rerio) we previously investigated GDNF
expression and localization, but no data exist regarding GFRalpha1 and RET presence. Thus, the present
study was designed to clarify the morphological relation between GDNF and its receptorial complex
GFRalpha1/RET immunoreactivity in the cerebellum of adult zebrafish. The expression of gdnf, GFRalpha1
and ret genes was demonstrated in adult zebrafish cerebellum by a standard RT-PCR. The distribution
of GDNF and its receptorial complex GFRalpha1/RET was examined by single and double immunocytochemical
stainings. In the valvula and corpus cerebelli GDNF, GFRalpha1 and RET immunoreactivity was
seen co-localized in Purkinje cells, identified morphologically and by using an antiserum against a specific
marker for these cells, aldolase C enzyme. In the vestibulolateralis lobe, Purkinje neurons were lacking
in both the eminentiae granulares and medial caudal lobe. These results demonstrated the expression of
the GDNF receptorial complex in adult zebrafish cerebellum and suggest an autocrine mode of action of
GDNF in Purkinje cells
Cellular localization of GDNF and its GFRalpha1/RET receptor complex in the developing pancreas of cat.
No full textSome peptides involved in food intake in the intestine and pancreas of buffalo: an immunohistochemical study.
No full textDistribution of glial cell line-derived neurotrophic factor receptor alpha-1 in the brain of adult zebrafish (vol 217, pg 174, 2010)
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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