1,720,968 research outputs found
Sex Steroids in ageing male
No full textEstrogens and testosterone declines with aging and serum estradiol remains higher in older men than in wome
Aromatase deficiency in the male: intriguing effects of testosterone, alendronate and estradiol treatment
No full textDescription of the fourth case of an adult man with aromatase deficiency, in particulare the effect of different treatment strategies on bone metabolism
Estrogeni e riproduzione maschile.
No full textThe effects of estrogen excess and estrogen deprivation on male reproductive function is reviewed and summarized
Terapia sostitutiva e maturazione ossea
No full textThis abstract summarize the role of sex steroids (in particular estrogens) played for the achievement of peak bone mass both in men and women
Resistance aux estrogenes et deficit en aromatase chez l’homme
No full textThe primordial role of estrogens in female reproductive function is well known. The recent production of transgenic mice deficient in estrogen receptors (ERKO) or in aromatase (ArKO) and the discovery in man of inactivating mutations of the corresponding genes (ER) have contributed to the understanding of the role of estrogens in metabolic processes in female as well as male. To date 8 well documented cases (5 women and 3 men) of congenital deficiencies in estrogens have been reported. As mice deficient in ERa had been previously described, these cases definitely proved that estrogen absence was compatible with survival and disproved the "lethality concept" previously held because the role of estrogens in implantation and gestation maintenance. ERKO mice are phenotypically normal though sterile, but their bone density is lower (20-25%) than that of controls. Similarly, men with no aromatase or no ER display continuous growth, osteoporosis and also (but not necessarily) alterations in testicular functions. How much do primordial functions such as bone development, control of gonadotrophin secretion and lipid metabolism depend on estrogens? These interrogations, elegantly clarified following testosterone and estradiol treatment in an aromatase deficient man are considered in this present synthesis
Sleep related erections in hypogonadal men: effect of both sildenafil and testosterone replacement therapy. Preliminary data of a randomized controlled study
No full textPreliminary data on a randomized placebo-controlled, crossover study evaluating a synergic effect of sildenafil and testosterone on sleep-related erections in hypogonadal me
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Effects of Sildenafil on sleep-related erections in normal men: randomized, placebo-controlled, crossover study
No full textThis randomized, placebo-controlled, crossover study demostrate that sildenafil is effective in improving sleep-related erection in healthy me
Il deficit estrogenico nell’uomo: aspetti clinici
No full textThe improvement of our knowledge of the natural history of congenital estrogen deficiency in men clarify the real impact of estrogens on me
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