12,928 research outputs found
Letter from Cy Donner to Michi Weglyn, June 2, 1967
No full textA letter from Cy Donner to Michi Weglyn encouraging her to come out to California to talk to producers about two shows called "Youthquake" and "Pretty Talk".These materials are from box 73 and 74 of the Frank Chin Papers. The Frank Chin Papers contain personal and professional correspondence between Frank Chin and Michi Weglyn relating to particular projects on which either author was working as well as files related to the Day of Remembrance Tribute to Michi Weglyn
Outcome of medium-dose VP-16/CY/TBI superior to CY/TBI as a conditioning regimen for allogeneic stem cell transplantation in adult patients with acute lymphoblastic leukemia
No full textThe choice of conditioning regimen before allogeneic stem cell transplantation (SCT) in patients with acute lymphoblastic leukemia (ALL) is important. We retrospectively compared outcomes of medium-dose VP-16/cyclophosphamide/total body irradiation (VP/CY/TBI) regimen and CY/TBI. Five hundred and twenty-nine patients (VP/CY/TBI: n = 35, CY/TBI: n = 494) who met all of the following criteria were compared: first time for SCT, aged 15-59 years; first or second complete remission at SCT; bone marrow or peripheral blood as stem cell source; and HLA phenotypically matched donor. Median age of the patients was 34 years, and patients who received VP/CY/TBI were younger (28 years vs. 34 years, P = 0.02). Cumulative incidences of relapse and non-relapse mortality (NRM) were higher for patients who received CY/TBI (P = 0.01 for relapse, P < 0.01 for NRM). After a median follow-up period of 36.9 months, 5-year overall survival (OS) rates were 82.2% in the VP/CY/TBI group and 55.2% in the CY/TBI group. OS, and disease-free survival (DFS) in the VP/CY/TBI group were shown to be significantly better by multivariate analysis [hazard ratio: 0.21 (95% confidence interval: 0.06-0.49) for DFS, hazard ratio: 0.25 (95% confidence interval: 0.08-0.59) for OS]. VP/CY/TBI was associated with a lower relapse rate and no increase in NRM, resulting in better survival than that in CY/TBI for adult ALL patients
Morning Cy!: barn dance
No full textGift of Dr. Mary Jane Esplen.Piano vocal [instrumentation]It was "Morning, Cy! Howdy!" [first line]F [key]Allegro Moderato [tempo]Popular piano ; barn dance[form/genre]Grover [graphic artist]Publisher's advertisement inside and back cover [note]"The universally accepted tune for the famous barn dance." [note
Synthetic, thermochemical, and catalytic studies of fluorinated tertiary phosphine ligands R2PRf [R = Cy, Ph, Pr-i; R-f = CH'2CH2(CF2)(5)CF3] in rhodium systems
No full textThe fluoroalkylphosphine compounds PR2Rf (R = Cy (1); Pr-i (2); R-f = CH2CH2(CF2)(5)CF3) have been prepared from the reactions of the Grignard reagent IMgRf and appropriate ClPR2 (R = Cy, Pr-i). The fluorinated phosphine ligands [PR2Rf (R = Cy (1); Pr-i (2); Ph (3); R-f = CH2CH2(CF2)(5)CF3] react with [Rh(CO)(2)Cl](2) to yield the corresponding [Rh(CO)Cl(PR2Rf)(2)] (R = Cy (4); Pr-i (5); Ph (6)) complexes. Infrared studies on the carbonyl complexes and solution calorimetry studies of the reaction of (Rh(CO)(2)Cl](2) with PR2Rf (R = Ph, Pr-i, Cy) have been used to quantify the relative ligand donor strength for the series: PCy2Rf approximate to (PPr2Rf)-Pr-i > PPh2Rf. The solid-state crystal structure of [Rh(CO)Cl(PPh2Rf)(2)] (6) is reported. Additionally, these partially fluorinated phosphine ligands (1 and 3) can be used as supporting ligation in rhodium-mediated hydrogenation reactions
Study protocol: diagnostic accuracy study comparing Cy-Tb and STANDARD F TB-Feron FIA tests for tuberculosis infection diagnosis in Vietnam
No full textIntroduction The large reservoir of tuberculosis (TB) infections is one of the main reasons for the persistent incidence of TB. Accurate diagnostic tests are crucial to correctly identify and treat people with TB infection, which is vital to eliminate TB globally. The rdESAT-6 and rCFP-10 (Cy-Tb) injection (‘Cy-Tb’), a TB-specific antigen skin test and STANDARD F TB-Feron FIA (‘Standard F TB’) measuring interferon-gamma by fluorescence immunoassay assay are two novel tools for the diagnosis of TB infection which offer advantages compared with current tests in low-resource settings and reduced costs to both health systems and TB-affected people. The proposed study aims to evaluate the diagnostic accuracy of these two new tests for TB infection diagnosis.Methods and analysis This cross-sectional study aims to assess the diagnostic accuracy for TB infection of the Cy-Tb skin test and Standard F TB assay (investigational tests) compared with the QuantiFERON-TB Gold Plus (QFT-Plus) assay as the immunological reference standard. Three different cohorts of study participants will be recruited at the Vietnam National Lung Hospital: adults with bacteriologically confirmed pulmonary TB (n=100), household contacts of people with TB (n=200) and people without TB infection (n=50). All consenting participants will undergo simultaneous testing with Cy-Tb, Standard F TB and QFT-Plus. The primary endpoint is the diagnostic accuracy of the Cy-Tb skin test and Standard F TB assay, expressed as sensitivity and specificity against the reference standard.</p
Petrography of phosphates in CI and CY carbonaceous chondrites
No full textPhosphate minerals are significant carriers of volatiles (e.g., OH) and halogens in chondritic material; however, their origin in most groups of carbonaceous chondrites remains poorly characterized. We have determined the abundance, morphology, texture, and composition of phosphate grains in aqueously altered CI chondrites and in hydrated and thermally metamorphosed Antarctic CY chondrites using scanning electron microscopy and electron probe microanalysis. Phosphates include apatite (formula Ca5(PO4)3X, where X = F‐, Cl‐, OH‐ or other anions) and sodium‐bearing magnesium phosphate, both of which formed during episodes of aqueous alteration on the CI and CY parent bodies. Apatite grains in the CI chondrites range up to 40 μm in size with a modal abundance of ~0.10 area%, while in the CYs, the largest grains are ~50 μm in size and the modal abundance is ≤0.70 area%. Analysis by secondary ion mass spectrometry (SIMS) indicates that apatite in the CYs contains ~1.0–1.8 wt% H2O, with δD values of −84‰ to 393‰ likely reflecting aqueous and thermal processing. Apatite in both the CI and CY chondrites is rich in fluorine, with fluorine abundances that range from 20 to 80 mole% of the X (anion) site. This contrasts with apatite in other chondrite groups, which is predominantly Cl‐rich. Estimated bulk chondrite F abundances based on F abundance in apatite are 12–21 ppm F for the CI chondrites and 61 ppm F for the CY chondrites. This is comparable to bulk CI chondrite F abundances in the literature, suggesting that most fluorine is hosted in apatite. However, the chlorine content of CI chondrite apatite (96.0 wt%). The occurrence of Mg,Na‐phosphates in the CI and Antarctic CY chondrites is indicative of brines on their respective parent bodies. Similarities between the two groups, as well as with the phosphate mineral assemblage in asteroids Ryugu and Bennu, indicate that comparable fluid compositions and environmental conditions were prevalent on numerous parent bodies in the early Solar System
A Recessive Lethal Gene, l-Cy, concealed in the Second Chromosome Balancer of Drosophila Melanogaster
No full textThe second chromosome balancer, SM 5[In(2(LR)SM 5)]Cy, has been used as a most useful tool to study the genetic variations in natural populations of Drosophila. melanogaster. The balancer suppresses recombination in almost whole region of the second chromosome since it has complicated inversions both in the right and left arms. It is lethal in the homozygous condition and it also has a dominant mutant, Cy, and several recessive mutations.Homozygous lethality has been explained by the presence of In(2 LR) or Cy itself. However, the cause of lethality is not necessarily clear. Recently, the author has found a recessive lethal gene in a natural population, which is allelic to these balancer chromosomes. In this short communication the author reports that the lethality of SM 5 chromosome in the homozygous condition is due to a recessive lethal gene, l-Cy (lethal Cy)
Tarin reduces cytotoxic effects in CY-immunosuppressed mice.
No full text(A) Leukocytes number in peripheral mice blood treated with: CY–CY-immunosuppressed mice; CY + Tarin–CY-immunosuppressed mice treated with 200 μg tarin on day 0, 2 and 5; Tarin–mice treated with 200 μg tarin on days 0, 2, and 5; and Control–animals inoculated with saline. Blood samples were collected on days 0, 2, 5, and 7. ***pvs Control comparison on day 2, and CY + Tarin vs CY on day 5. *p(B) Occurrence of micronuclei in BM erythroid cells from: CY300—mice immunosuppressed with 300 mg/kg CY; CY50—mice immunosuppressed with 50 mg/kg; CY300 + Tarin—mice immunosuppressed with 300 mg/kg and treated with 200 μg tarin and CY50 + Tarin—mice immunosuppressed with 50 mg/kg and treated with 200 μg tarin. ***ppCY50 to CY50+Tarin, and #pCY300 to CY300+Tarin.</p
Petrography of phosphates in CI and CY carbonaceous chondrites
No full textPhosphate minerals are significant carriers of volatiles (e.g., OH) and halogens in chondritic material, however, their origin in most groups of carbonaceous chondrites remains poorly characterized. We have determined the abundance, morphology, texture, and composition of phosphate grains in aqueously altered CI chondrites and the hydrated and thermally metamorphosed CY chondrites using scanning electron microscopy and electron probe microanalysis. Phosphates include apatite (formula Ca5(PO4)3X, where X = F-, Cl-, OH- or other anions) and sodium-bearing magnesium phosphate, both of which formed during episodes of aqueous alteration on the CI and CY parent bodies. Apatite grains in the CI chondrites range up to 40 µm in size with a modal abundance of ~0.10 area%, while in the CYs the largest grains are ~50 µm in size and the modal abundance is ≤0.70 area %. Analysis by secondary ion mass spectrometry (SIMS) indicates that apatite in the CYs contains ~1.0 – 1.8 wt.% H2O, with δD values of −84 to 393 ‰ likely reflecting aqueous and thermal processing. Apatite in both the CI and CY chondrites is rich in fluorine, with fluorine abundances that range from 20 – 80 mol% of the X (anion) site. This contrasts with apatite in other chondrite groups, which is predominantly Cl-rich. Estimated bulk chondrite F abundances determined from apatite are 12 – 21 ppm F for the CI chondrites, and 61 ppm F for the CY chondrites. This is comparable to bulk CI chondrite F abundances in the literature, suggesting that most fluorine is hosted in apatite. However, the chlorine content of CI chondrite apatite (<0.05 wt%) is too low to account for the bulk chondrite Cl abundance, indicating that Cl is hosted in other phases. Mg,Na-phosphate, a rare extraterrestrial mineral, has a modal abundance of ~0.02 area% in both the CI and CY chondrites. Mg,Na-phosphates in the CI and CY chondrites are halogen poor (<0.15 wt.%), and are typically hydrated in the CIs (analytical totals as low as 67 wt.%) and dehydrated in the CYs (analytical totals >96.0 wt.%). The occurrence of Mg,Na-phosphates in the CI and CY chondrites is indicative of brines on their respective parent bodies. Similarities between the two groups, as well as with the phosphate mineral assemblage in asteroids Ryugu and Bennu, indicate that comparable fluid compositions and environmental conditions were prevalent on numerous parent bodies in the early Solar System
A Poetics of becoming: the mythography of Cy Twombly
No full textA Poetics of Becoming: The Mythography of Cy Twombly, centres upon Proteus, a painting made by the artist Cy Twombly in 1984. The chapter uses this particular work as a means of unpacking the artist's complex and manifold relationship with mythology. With regards to both the facture and the matiere of Proteus, the author argues that the visual poetics of the artist's work results from what is claimed to be the painting's "becoming
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