1,721,222 research outputs found
'Vedere' l'invisibile. Rileggendo il XXXIV libro Sulla Natura di Epicuro (PHerc 1431)
No full textAl centro dei vari contributi è il PHerc. 1431, che ha trasmesso il XXXIV libro dell'opera di Epicuro Sulla natura. Gli autori ne discutono i vari aspetti, avanzando nuove proposte di lettura e di esegesi
Tau proteins in blood as biomarkers of Alzheimer’s disease and other proteinopathies
No full textAlzheimer’s disease (AD), the most common age-dependent neurodegenerative disorder, is characterized neuropathologically by extracellular Aβ plaques and intracellular tau neurofibrillary tangles. While in AD tau pathology probably follows early alterations in Aβ metabolism, it develops independently in the so-called primary tauopathies, the main form being frontotemporal lobar degeneration with tau pathology. Tau pathology in AD brain is reflected in the cerebrospinal fluid (CSF) by elevated levels of the two AD tau biomarkers total and phosphorylated tau, which are now used for routine diagnostic purposes. On the contrary, no established neurochemical biomarkers exist for tau pathology in primary tauopathies. Thanks to recent technological advances, total and phosphorylated tau can now be quantified also on peripheral blood, and accumulating evidence shows that measurement of plasma phosphorylated tau species (P-tau181, P-tau217, and P-tau231) has high performances in discriminating AD patients from cognitively unimpaired subjects but also from patients with other dementias. Moreover, plasma P-tau levels are associated with tracer uptake on tau- and amyloid-PET as well as with brain atrophy, cognitive measures and longitudinal changes of these parameters. These features, together with the low invasiveness, scalability, and ease of longitudinal sampling, which differentiate plasma P-tau species from their CSF counterparts, make these proteins promising peripheral biomarkers for AD in both research and clinical setting. This review discusses the recent developments in the field of plasma tau proteins as diagnostic, pathophysiological and prognostic biomarkers of Alzheimer’s disease; additional findings from the fields of genetic forms of AD and of non-AD proteinopathies are also summarized
INTRODUCTION TO EPICUREANISM AND SCIENTIFIC DEBATES: ANTIQUITY AND LATE RECEPTION. VOLUME I. LANGUAGE, MEDICINE, METEOROLOGY
No full textIntroduction to the volume Epicureanism and Scientific Debates. Antiquity and Late Reception. Volume I: Language, Medicine, Meteorolog
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
The Scientific Lexicon in Epicurus, On Nature XI: Some Observations, in Epicureanism and Scientific Debates: Epicurean Tradition and its Ancient Reception
No full textThis article outlines an exegetical method applicable to the technical-scientific language employed in Epicurus’ On Nature. The author addresses the question of the immobility (mone) of the earth in light of a passage from Book XI of On Nature devoted to the study of celestial and meteorological phenomena, reconstructing the meaning of a key term used by Epicurus, pyknotes, ‘density’, and related words through an examination of the various contexts in which they occur within Epicurus’ corpus
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Interpretazioni di Epicuro fra Cosma Raimondi e Giordano Bruno
No full textIl contributo ricostruisce una linea interpretativa della filosofia di Epicuro che attraversa l’età rinascimentale facendo leva sul nesso fra riflessione naturale e prospettiva etico-politica
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