1,720,955 research outputs found
Fattori psicologici in pazienti affetti da epatite C in fase di pre-trattamento
No full textObiettivi: Nel presente studio controllato sono stati esplorati i costrutti psicologici di qualità della vita (QoL), rabbia
e sintomi depressivi in pazienti con epatite C (HCV) prima del trattamento antivirale confrontandoli con un campione
della popolazione generale.
Metodi: Lo studio comprende un campione sperimentale (56 pazienti HCV positivi) ed un campione di controllo (66
individui sani). Ad entrambi i gruppi sono stati somministrati i seguenti test psicometrici auto-valutativi: Beck Depression
Inventory-II (BDI-II; Beck et al., 1996), State-trait Anger Expression Inventory-2 (STAXI-2; Spielberger, 1999), World
Health Organization Quality of Life Instruments (WHOQOL-BREF; Whoqol Group, 1995).
Risultati e Conclusioni: I pazienti HCV hanno mostrato punteggi significativamente inferiori nelle scale del WHOQOLBREF,
superiori nella “rabbia di stato” (S-Rab; STAXI-2) e nel BDI-II rispetto ai controlli. Nel gruppo sperimentale S-Rab
e T-Rab (rabbia di tratto) correlano negativamente con le scale del WHOQOL-BREF e positivamente con il BDI-II.
Inoltre le donne HVC mostravano qualità di vita e umore peggiori rispetto ai pazienti maschi e maggiore rabbia di stato.
Si può dunque concludere che i pazienti HCV presentano una minore soddisfazione nella propria vita, maggiore rabbia
contingente e sintomi depressivi, rispetto agli individui sani
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
EFFECTS OF SLEEP DEPRIVATION IN THE PROCESS OF TAU PROTEIN DEPHOSPHORYLATION FOLLOWING SYNTHETIC TORPOR IN THE RAT
No full textIntroduction:One of the main hallmarks of tauopathies is the hyperphosphorylation
of neuronal Tau protein. Interestingly, the accumulation
of hyperphosphorylated Tau (PPTau) also characterizes “synthetic torpor”
(ST), a torpor-like condition that can be pharmacologically induced in rats
(Cerri et al., 2013). However, after few hours of the recovery from ST, PPTau
levels reverse to control (Luppi et al., 2019). Since during the first hours of
the recovery from ST rats show a strong sleep-pressure, aim of the present
study has been to investigate the role of sleep in the dephosphorylation of
PPTau following ST.
Materials and Methods:Twelve Sprague-Dawley male rats (250-350g),
adapted to an ambient temperature (Ta) of 24±0.5 C and to a 12h:12h
Light-Dark cycle, were implanted under general anesthesia with a microcannula
in the Raphe Pallidus (RP). After one-week of recovery, ST was
induced for 6 hours according to the protocol described by Cerri et al.
(2013), by the repeated injection (one injection/h) in the RP of the GABA-A
agonist muscimol (100 nL - 1 mM). Soon after their return to normothermia,
animals were either sleep deprived by gentle handling for 3 (n1⁄43)
or 6 (n1⁄43) hours (R3SD and R6SD, respectively) or allowed to sleep
(normal sleep, NS) for 3 (n1⁄43) or 6 (n1⁄43) hours (R3NS and R6NS,
respectively). Soon after animals’ euthanasia, fresh sample of parietal
cortex (P-Cx) were collected in order to evaluate byWestern Blot the levels
of the following proteins and enzymes: AT8 (p[Ser202/Thr205]-Tau,
phosphorylated Tau form), Tau-1 (unphosphorylated Tau form), p[Thr205]-Tau (a neuroprotective form of phosphorylated Tau; Ittner et al., 2016); p[Ser9]-GSK3b (the inhibited form of the main kinase targeting
Tau); PP2A (the main phosphatase targeting Tau) and p[Ser473]-Akt2
(active anti-apoptotic factor and GSK3b inhibitor). Moreover, the plasma
levels of melatonin were determined by ELISA.Results:Overall, AT8 levels were reduced in the SD groups compared to the NS ones (p<0.05), while Tau-1 levels were not significantly affected. A clear
trend towards higher p[Thr205]-Tau levels was also observed after SD. The
decrease in PPTau induced by SDwas accompanied by an increase in both p
[Ser9]-GSK3b and p[Ser473]-Akt2 levels, although statistical significance
was reached only for the latter (p<0.05). Also, PP2A levels were lower in
R3SD vs. R3NS (p< 0.05). Finally, melatonin levels were higher in R3SD vs. R3 (p <0.05).
Conclusions:The present results indicate that SD soon after ST enhances
PPTau dephosphorylation, coherently with the observed concomitant increase
of p[Ser9]-GSK3b and p[Ser473]-Akt2. This molecular pattern is
known as being neuroprotective, and may be mediated by melatonin that
can activate Akt2 and, consequently, inhibit GSK3b by acting on the PI3K/
Akt2/mTOR antiapoptotic pathway (Risso et al., 2015). These findings open
interestingly translational perspectives in the use of sleep deprivation in
patients suffering from hypothermia-induced brain PPTau formation due
to general anesthesia (Whittington et al., 2013).
Acknowledgements: The authors wish to thank Fondazione Carisbo that
supported this work
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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