179 research outputs found
Operational Experience and Performance with the ATLAS Pixel detector at the Large Hadron Collider at CERN
No full textThe tracking performance of the ATLAS detector relies critically on its 4-layer Pixel Detector which has undergone significant hardware and readout upgrades to meet the challenges imposed by the higher collision energy, pileup and luminosity delivered by the Large Hadron Collider (LHC), with record breaking instantaneous luminosities of 2 x 10^34 cm-2 s-1 recently surpassed. The key status and performance metrics of the ATLAS Pixel Detector are summarized, and the operational experience and requirements to ensure optimum data quality and data taking efficiency will be described, with special emphasis on radiation damage experience
Corrigendum to “The effect of public tolerance towards corruptive behaviour on healthcare efficiency and equity – The case of the UK's COVID-19 vaccination programme” [Soc. Sci. Med. Volume 361, November 2024, 117180] (Social Science & Medicine (2024) 361, (S0277953624006336), (10.1016/j.socscimed.2024.117180))
No full textCase-control studies with affected sibships
No full textAbstract Related cases may be included in case-control association studies if correlations between related individuals due to identity-by-descent (IBD) sharing are taken into account. We derived a framework to test for association in a case-control design including affected sibships and unrelated controls. First, a corrected variance for the allele frequency difference between cases and controls was directly calculated or estimated in two ways on the basis of the fixation index F ST and the inbreeding coefficient. Then the correlation-corrected association test including controls and affected sibs was carried out. We applied the three strategies to 20 candidate genes on the Genetic Analysis Workshop 15 rheumatoid arthritis data and to 9187 single-nucleotide polymorphisms of replicate one of the Genetic Analysis Workshop 15 simulated data with knowledge of the "answers". The three strategies used to correct for correlation give only minor differences in the variance estimates and yield an almost correct type I error rate for the association tests. Thus, all strategies considered to correct the variance performed quite well
Ludwig Rehn (1849-1930): the German surgeon who performed the worldwide first successful cardiac operation.
No full textLudwig Rehn, a German surgeon, performed the worldwide first successful cardiac operation in 1896 when he repaired a stab wound to the heart by direct suture. When he presented his work one year later at a surgical conference this pioneering operation evoked considerable ethical discussion. Rehn's surgical contributions also include carrying out the first thyroidectomy in 1880 and clarifying the causes of cancer in workers in the local aniline factories
In Castle-Htx Trial We Trust
No full textSohns C, Marrouche NF, Crijns HJGM, et al. In CASTLE-HTx Trial We Trust. Journal of the American College of Cardiology. 2024
Misleading Long Post-Pacing Interval After Entrainment of Typical Atrial Flutter From the Cavotricuspid Isthmus
No full textObjectivesThe purpose of this study was to evaluate the prevalence and mechanism of a misleading long post-pacing interval (PPI) upon entrainment of typical atrial flutter (AFL) from the cavotricuspid isthmus (CTI).BackgroundIn typical AFL, the PPI from entrainment at the CTI is expected to closely match the tachycardia cycle-length (TCL).MethodsSixty patients with confirmed CTI-dependent AFL were retrospectively analyzed and grouped into short (≤30 ms) or long (>30 ms) PPI-TCL. Thereafter, we prospectively studied 16 patients to acquire the PPI-TCL at 4 CTI sites with entrainment at pacing cycle-lengths (PCLs) 10 to 40 ms shorter than the TCL. Conduction times during AFL and entrainment were compared in 5 segments of the AFL circuit.ResultsEleven patients (18%) in the retrospective analysis had a long PPI-TCL after entrainment from the CTI. Subjects with long PPI-TCL had similar baseline characteristics but greater beat-to-beat TCL variability. In the prospective cohort, PPI-TCL was influenced by the difference between PCL and TCL and site of entrainment. Conduction delays associated with a long PPI-TCL were located predominantly in the segment activated first by the paced orthodromic wave front, and were mainly due to local pacing latency, as confirmed by the use of monophasic action potential catheters.ConclusionsA long PPI upon entrainment of typical AFL from the CTI is common and due to delayed conduction with entrainment. Whether these findings apply to other macro–re-entrant tachycardias warrants further investigation
Des weyland Durchlauchtigsten Fürsten und Herrn/ Herrn Ernsten/ Hertzogen zu Sachsen/ Jülich/ Cleve und Berg ... Hochseeligsten Andenckens/ Ordnungen/ Das Kirchen- und Schulwesen betreffende
No full textAuf Befehl Seiner Fürstl. Durchl. Hrn. Sohns ... Herrn Ernsten/ Hertzogen zu Sachsen/ Jülich/ Cleve und Berg ... Zusammen getragen ...Teil 1/2 u.d.T.: Fürstl. Ernestinischer erneuerter Ordnungen/ Das Kirchen- und Schul-Wesen betreffende ... TheilVorlageform des Erscheinungsvermerks: Hildburghausen/ Gedruckt und zu finden bey Samuel Wentzeln/ F. S. BuchdrErschienen: 1 (1685) - 2 (1685
German exports and economic development
No full textThe influence of the export trade on the economic development since 1974 shows how greatly economic activities in the Federal Republic of Germany depend upon the situation abroad. In this context the author analyses the regional distribution and the goods structure of German exports and discusses their medium-term prospects
Catheter Ablation in Patients with End-Stage Heart Failure and Atrial Fibrillation:Two-year Follow-up of the CASTLE-HTx Trial
No full textSohns C, Moersdorf M, Marrouche NF, et al. Catheter Ablation in Patients with End-Stage Heart Failure and Atrial Fibrillation: Two-year Follow-up of the CASTLE-HTx Trial. Circulation. 2024
T-wave alternans, heart rate turbulence and ventricular extrasystoles for the prediction of appropriate implantable cardioverter-defibrillator discharges
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